Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients
The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Tha...
Gespeichert in:
| Veröffentlicht in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2009-04, Vol.117 (4), p.286-290 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 290 |
|---|---|
| container_issue | 4 |
| container_start_page | 286 |
| container_title | APMIS : acta pathologica, microbiologica et immunologica Scandinavica |
| container_volume | 117 |
| creator | CHEUNOY, WATTANA HAILE, MELLES CHAIPRASERT, ANGKANA PRAMMANANAN, THERDSAK CRISTEA-FERNSTRÖM, MARIANA VONDRACEK, MARTIN CHRYSSANTHOU, ERJA HOFFNER, SVEN PETRINI, BJÖRN |
| description | The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug-resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single-drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB. |
| doi_str_mv | 10.1111/j.1600-0463.2009.02438.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_558808</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67113371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5948-a0cbe77e1e712ce6466459a91a8c1251f6c16ba8f0faaffd97b12a761320f5a23</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEokvhL0AucMvisR07OXAohbZILVTqVkhcrInXXrzNx2In6u6_r9ONtuIEvnjs95nxaF4nSQpkDnF9XM9BEJIRLticElLOCeWsmG-fJbOD8DyZkZKwjAsOR8mrENaEAC2EfJkcQckiT_ksqb_4YZV6E1zosdUmxXaZrkzb9buN0_GE9S5qaWfTq53uKtS98W5o0n6ojNdD3Y1q6D26NqTWd026-I3ub3mDvTNtH14nLyzWwbyZ9uPk9uzr4vQiu_xx_u305DLTecmLDImujJQGjASqjeBC8LzEErDQQHOwQoOosLDEIlq7LGUFFKUARonNkbLjJNvXDfdmM1Rq412Dfqc6dGq6uouRUXleFKSI_Ic9v_Hdn8GEXjUuaFPX2JpuCEpIAMYk_BOkJOelfASLPah9F4I39tADEDVaqNZqdEqNTqnRQvVoodrG1LfTG0PVmOVT4uRZBN5PAAaNtfXRNxcOHAVa8pySyH3ac_euNrv_bkCdXF-N0dMU49cw20M--rs4ECZz9fP7ueK_LuDmM1-o68i_2_MWO4UrH3u6vaEEGAEBhDPJHgA6K9H4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20549771</pqid></control><display><type>article</type><title>Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>CHEUNOY, WATTANA ; HAILE, MELLES ; CHAIPRASERT, ANGKANA ; PRAMMANANAN, THERDSAK ; CRISTEA-FERNSTRÖM, MARIANA ; VONDRACEK, MARTIN ; CHRYSSANTHOU, ERJA ; HOFFNER, SVEN ; PETRINI, BJÖRN</creator><creatorcontrib>CHEUNOY, WATTANA ; HAILE, MELLES ; CHAIPRASERT, ANGKANA ; PRAMMANANAN, THERDSAK ; CRISTEA-FERNSTRÖM, MARIANA ; VONDRACEK, MARTIN ; CHRYSSANTHOU, ERJA ; HOFFNER, SVEN ; PETRINI, BJÖRN</creatorcontrib><description>The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug-resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single-drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB.</description><identifier>ISSN: 0903-4641</identifier><identifier>EISSN: 1600-0463</identifier><identifier>DOI: 10.1111/j.1600-0463.2009.02438.x</identifier><identifier>PMID: 19343824</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents - pharmacology ; Bacteriology ; Beijing genotype ; Biological and medical sciences ; Child ; Child, Preschool ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; DR-TB ; drug resistance ; Drug Resistance, Multiple, Bacterial ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Humans ; Infectious diseases ; Male ; MDR-TB ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - growth & development ; Mycobacterium tuberculosis - isolation & purification ; Polymerase Chain Reaction ; Retrospective Studies ; Sequence Analysis, DNA ; Thailand - epidemiology ; Tuberculosis ; Tuberculosis - drug therapy ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; XDR-TB ; Young Adult</subject><ispartof>APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2009-04, Vol.117 (4), p.286-290</ispartof><rights>2009 The Authors. Journal Compilation © 2009 APMIS</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5948-a0cbe77e1e712ce6466459a91a8c1251f6c16ba8f0faaffd97b12a761320f5a23</citedby><cites>FETCH-LOGICAL-c5948-a0cbe77e1e712ce6466459a91a8c1251f6c16ba8f0faaffd97b12a761320f5a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0463.2009.02438.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0463.2009.02438.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21294520$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19343824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118493003$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEUNOY, WATTANA</creatorcontrib><creatorcontrib>HAILE, MELLES</creatorcontrib><creatorcontrib>CHAIPRASERT, ANGKANA</creatorcontrib><creatorcontrib>PRAMMANANAN, THERDSAK</creatorcontrib><creatorcontrib>CRISTEA-FERNSTRÖM, MARIANA</creatorcontrib><creatorcontrib>VONDRACEK, MARTIN</creatorcontrib><creatorcontrib>CHRYSSANTHOU, ERJA</creatorcontrib><creatorcontrib>HOFFNER, SVEN</creatorcontrib><creatorcontrib>PETRINI, BJÖRN</creatorcontrib><title>Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients</title><title>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</title><addtitle>APMIS</addtitle><description>The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug-resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single-drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Bacteriology</subject><subject>Beijing genotype</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>DR-TB</subject><subject>drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>MDR-TB</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - growth & development</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Polymerase Chain Reaction</subject><subject>Retrospective Studies</subject><subject>Sequence Analysis, DNA</subject><subject>Thailand - epidemiology</subject><subject>Tuberculosis</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - microbiology</subject><subject>XDR-TB</subject><subject>Young Adult</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhL0AucMvisR07OXAohbZILVTqVkhcrInXXrzNx2In6u6_r9ONtuIEvnjs95nxaF4nSQpkDnF9XM9BEJIRLticElLOCeWsmG-fJbOD8DyZkZKwjAsOR8mrENaEAC2EfJkcQckiT_ksqb_4YZV6E1zosdUmxXaZrkzb9buN0_GE9S5qaWfTq53uKtS98W5o0n6ojNdD3Y1q6D26NqTWd026-I3ub3mDvTNtH14nLyzWwbyZ9uPk9uzr4vQiu_xx_u305DLTecmLDImujJQGjASqjeBC8LzEErDQQHOwQoOosLDEIlq7LGUFFKUARonNkbLjJNvXDfdmM1Rq412Dfqc6dGq6uouRUXleFKSI_Ic9v_Hdn8GEXjUuaFPX2JpuCEpIAMYk_BOkJOelfASLPah9F4I39tADEDVaqNZqdEqNTqnRQvVoodrG1LfTG0PVmOVT4uRZBN5PAAaNtfXRNxcOHAVa8pySyH3ac_euNrv_bkCdXF-N0dMU49cw20M--rs4ECZz9fP7ueK_LuDmM1-o68i_2_MWO4UrH3u6vaEEGAEBhDPJHgA6K9H4</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>CHEUNOY, WATTANA</creator><creator>HAILE, MELLES</creator><creator>CHAIPRASERT, ANGKANA</creator><creator>PRAMMANANAN, THERDSAK</creator><creator>CRISTEA-FERNSTRÖM, MARIANA</creator><creator>VONDRACEK, MARTIN</creator><creator>CHRYSSANTHOU, ERJA</creator><creator>HOFFNER, SVEN</creator><creator>PETRINI, BJÖRN</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>200904</creationdate><title>Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients</title><author>CHEUNOY, WATTANA ; HAILE, MELLES ; CHAIPRASERT, ANGKANA ; PRAMMANANAN, THERDSAK ; CRISTEA-FERNSTRÖM, MARIANA ; VONDRACEK, MARTIN ; CHRYSSANTHOU, ERJA ; HOFFNER, SVEN ; PETRINI, BJÖRN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5948-a0cbe77e1e712ce6466459a91a8c1251f6c16ba8f0faaffd97b12a761320f5a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Bacteriology</topic><topic>Beijing genotype</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>DR-TB</topic><topic>drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>MDR-TB</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - growth & development</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Polymerase Chain Reaction</topic><topic>Retrospective Studies</topic><topic>Sequence Analysis, DNA</topic><topic>Thailand - epidemiology</topic><topic>Tuberculosis</topic><topic>Tuberculosis - drug therapy</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - microbiology</topic><topic>XDR-TB</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEUNOY, WATTANA</creatorcontrib><creatorcontrib>HAILE, MELLES</creatorcontrib><creatorcontrib>CHAIPRASERT, ANGKANA</creatorcontrib><creatorcontrib>PRAMMANANAN, THERDSAK</creatorcontrib><creatorcontrib>CRISTEA-FERNSTRÖM, MARIANA</creatorcontrib><creatorcontrib>VONDRACEK, MARTIN</creatorcontrib><creatorcontrib>CHRYSSANTHOU, ERJA</creatorcontrib><creatorcontrib>HOFFNER, SVEN</creatorcontrib><creatorcontrib>PETRINI, BJÖRN</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEUNOY, WATTANA</au><au>HAILE, MELLES</au><au>CHAIPRASERT, ANGKANA</au><au>PRAMMANANAN, THERDSAK</au><au>CRISTEA-FERNSTRÖM, MARIANA</au><au>VONDRACEK, MARTIN</au><au>CHRYSSANTHOU, ERJA</au><au>HOFFNER, SVEN</au><au>PETRINI, BJÖRN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>2009-04</date><risdate>2009</risdate><volume>117</volume><issue>4</issue><spage>286</spage><epage>290</epage><pages>286-290</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><abstract>The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug-resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single-drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>19343824</pmid><doi>10.1111/j.1600-0463.2009.02438.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0903-4641 |
| ispartof | APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2009-04, Vol.117 (4), p.286-290 |
| issn | 0903-4641 1600-0463 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_558808 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Antitubercular Agents - pharmacology Bacteriology Beijing genotype Biological and medical sciences Child Child, Preschool DNA, Bacterial - chemistry DNA, Bacterial - genetics DR-TB drug resistance Drug Resistance, Multiple, Bacterial Female Fundamental and applied biological sciences. Psychology Genotype Humans Infectious diseases Male MDR-TB Medical sciences Microbiology Middle Aged Miscellaneous Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - isolation & purification Polymerase Chain Reaction Retrospective Studies Sequence Analysis, DNA Thailand - epidemiology Tuberculosis Tuberculosis - drug therapy Tuberculosis - epidemiology Tuberculosis - microbiology XDR-TB Young Adult |
| title | Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T04%3A19%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Drug%20resistance%20and%20genotypic%20analysis%20of%20Mycobacterium%20tuberculosis%20strains%20from%20Thai%20tuberculosis%20patients&rft.jtitle=APMIS%20:%20acta%20pathologica,%20microbiologica%20et%20immunologica%20Scandinavica&rft.au=CHEUNOY,%20WATTANA&rft.date=2009-04&rft.volume=117&rft.issue=4&rft.spage=286&rft.epage=290&rft.pages=286-290&rft.issn=0903-4641&rft.eissn=1600-0463&rft_id=info:doi/10.1111/j.1600-0463.2009.02438.x&rft_dat=%3Cproquest_swepu%3E67113371%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20549771&rft_id=info:pmid/19343824&rfr_iscdi=true |