Methylation of 12S rRNA Is Necessary for In Vivo Stability of the Small Subunit of the Mammalian Mitochondrial Ribosome

The 3′ end of the rRNA of the small ribosomal subunit contains two extremely highly conserved dimethylated adenines. This modification and the responsible methyltransferases are present in all three domains of life, but its function has remained elusive. We have disrupted the mouse Tfb1m gene encodi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2009-04, Vol.9 (4), p.386-397
Hauptverfasser:	Metodiev, Metodi D., Lesko, Nicole, Park, Chan Bae, Cámara, Yolanda, Shi, Yonghong, Wibom, Rolf, Hultenby, Kjell, Gustafsson, Claes M., Larsson, Nils-Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomyopathies - metabolism Cardiomyopathies - pathology DNA DNA, Mitochondrial - genetics Electron Transport Embryonic Development Gene Expression Regulation, Developmental HUMDISEASE Mammals - metabolism Methylation Mice Mice, Knockout Mitochondria - genetics Mitochondria - metabolism Mitochondria - ultrastructure Myocardium - pathology Myocardium - ultrastructure Organ Specificity Protein Biosynthesis Ribosome Subunits, Small, Eukaryotic - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Ribosomal - metabolism Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!