Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages
Ventral telencephalic progenitors expressing the homeodomain transcription factor Nkx6-2 have been shown to give rise to a multitude of cortical interneuron subtypes usually associated with origin in either the medial ganglionic eminence or the caudal ganglionic eminence. The function of Nkx6-2 in d...
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| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2009-07, Vol.19 (suppl-1), p.i1-i10 |
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| container_title | Cerebral cortex (New York, N.Y. 1991) |
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| creator | Sousa, Vitor H. Miyoshi, Goichi Hjerling-Leffler, Jens Karayannis, Theofanis Fishell, Gord |
| description | Ventral telencephalic progenitors expressing the homeodomain transcription factor Nkx6-2 have been shown to give rise to a multitude of cortical interneuron subtypes usually associated with origin in either the medial ganglionic eminence or the caudal ganglionic eminence. The function of Nkx6-2 in directing the fate of those progenitors has, however, not been thoroughly analyzed. We used a combination of genetic inducible fate mapping and in vivo loss-of-function to analyze the requirement of Nkx6-2 in determining the fate of cortical interneurons. We have found that interneuron subtypes are born with a characteristic temporal pattern. Furthermore, we extend the characterization of interneurons from the Nkx6-2 lineage through the application of electrophysiological methods. Analysis of these populations in Nkx6-2 null mice suggests that there is a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons in the absence of Nkx6-2 gene function. |
| doi_str_mv | 10.1093/cercor/bhp038 |
| format | Article |
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The function of Nkx6-2 in directing the fate of those progenitors has, however, not been thoroughly analyzed. We used a combination of genetic inducible fate mapping and in vivo loss-of-function to analyze the requirement of Nkx6-2 in determining the fate of cortical interneurons. We have found that interneuron subtypes are born with a characteristic temporal pattern. Furthermore, we extend the characterization of interneurons from the Nkx6-2 lineage through the application of electrophysiological methods. Analysis of these populations in Nkx6-2 null mice suggests that there is a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons in the absence of Nkx6-2 gene function.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhp038</identifier><identifier>PMID: 19363146</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; genetic fate mapping ; Homeodomain Proteins - metabolism ; interganglionic sulcus ; Interneurons - cytology ; Interneurons - physiology ; loss of function ; Mice ; Mice, Knockout ; mouse genetics ; Neocortex - cytology ; Neocortex - growth & development ; Tissue Distribution ; Transcription Factors - metabolism ; whole-cell physiology</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2009-07, Vol.19 (suppl-1), p.i1-i10</ispartof><rights>2009 The Authors 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-c029f7d452092735e58e92ee9d34948504eea73e66524d47b53455c14a4284513</citedby><cites>FETCH-LOGICAL-c604t-c029f7d452092735e58e92ee9d34948504eea73e66524d47b53455c14a4284513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,551,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19363146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:119079256$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Sousa, Vitor H.</creatorcontrib><creatorcontrib>Miyoshi, Goichi</creatorcontrib><creatorcontrib>Hjerling-Leffler, Jens</creatorcontrib><creatorcontrib>Karayannis, Theofanis</creatorcontrib><creatorcontrib>Fishell, Gord</creatorcontrib><title>Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Ventral telencephalic progenitors expressing the homeodomain transcription factor Nkx6-2 have been shown to give rise to a multitude of cortical interneuron subtypes usually associated with origin in either the medial ganglionic eminence or the caudal ganglionic eminence. The function of Nkx6-2 in directing the fate of those progenitors has, however, not been thoroughly analyzed. We used a combination of genetic inducible fate mapping and in vivo loss-of-function to analyze the requirement of Nkx6-2 in determining the fate of cortical interneurons. We have found that interneuron subtypes are born with a characteristic temporal pattern. Furthermore, we extend the characterization of interneurons from the Nkx6-2 lineage through the application of electrophysiological methods. Analysis of these populations in Nkx6-2 null mice suggests that there is a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons in the absence of Nkx6-2 gene function.</description><subject>Animals</subject><subject>genetic fate mapping</subject><subject>Homeodomain Proteins - metabolism</subject><subject>interganglionic sulcus</subject><subject>Interneurons - cytology</subject><subject>Interneurons - physiology</subject><subject>loss of function</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>mouse genetics</subject><subject>Neocortex - cytology</subject><subject>Neocortex - growth & development</subject><subject>Tissue Distribution</subject><subject>Transcription Factors - metabolism</subject><subject>whole-cell physiology</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNpVkTlPAzEQhS0E4giUtCglzYJvrxskFE4pQAEIRGM53gkx2ayDveH69RglIiAXHs37_Gbkh9AuwQcEa3boILoQDwejKWblCtokXOKCEq1Xc425KhglZANtpfSCMVFU0HW0QTSTLJObqNcb2WhdC9F_2daHphuG3evxhyxocZKbb1B1ryHkEa13tu5eNhltYBYz2fcN2GdI22htaOsEO4u7g-7PTu96F0X_5vyyd9wvnMS8LRymeqgqLijWVDEBogRNAXTFuOalwBzAKgZSCsorrgaCcSEc4ZbTkgvCOqiY-6Z3mM4GZhr9xMZPE6w3i9Y4V2CEKKXSmT-a81mZQOWgaaOt_z37rzR-ZJ7Dm6FSM5FPB-0vDGJ4nUFqzcQnB3VtGwizZAjXNP-j4nK5m4shpQjD3zEEm5-gzDwoMw8q83t_d1vSi2SWhj618PGr2zg2UjElzMXjk7klt-XDSV-bK_YNGkqgJg</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Sousa, Vitor H.</creator><creator>Miyoshi, Goichi</creator><creator>Hjerling-Leffler, Jens</creator><creator>Karayannis, Theofanis</creator><creator>Fishell, Gord</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20090701</creationdate><title>Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages</title><author>Sousa, Vitor H. ; Miyoshi, Goichi ; Hjerling-Leffler, Jens ; Karayannis, Theofanis ; Fishell, Gord</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-c029f7d452092735e58e92ee9d34948504eea73e66524d47b53455c14a4284513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>genetic fate mapping</topic><topic>Homeodomain Proteins - metabolism</topic><topic>interganglionic sulcus</topic><topic>Interneurons - cytology</topic><topic>Interneurons - physiology</topic><topic>loss of function</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>mouse genetics</topic><topic>Neocortex - cytology</topic><topic>Neocortex - growth & development</topic><topic>Tissue Distribution</topic><topic>Transcription Factors - metabolism</topic><topic>whole-cell physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sousa, Vitor H.</creatorcontrib><creatorcontrib>Miyoshi, Goichi</creatorcontrib><creatorcontrib>Hjerling-Leffler, Jens</creatorcontrib><creatorcontrib>Karayannis, Theofanis</creatorcontrib><creatorcontrib>Fishell, Gord</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sousa, Vitor H.</au><au>Miyoshi, Goichi</au><au>Hjerling-Leffler, Jens</au><au>Karayannis, Theofanis</au><au>Fishell, Gord</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>19</volume><issue>suppl-1</issue><spage>i1</spage><epage>i10</epage><pages>i1-i10</pages><issn>1047-3211</issn><eissn>1460-2199</eissn><abstract>Ventral telencephalic progenitors expressing the homeodomain transcription factor Nkx6-2 have been shown to give rise to a multitude of cortical interneuron subtypes usually associated with origin in either the medial ganglionic eminence or the caudal ganglionic eminence. The function of Nkx6-2 in directing the fate of those progenitors has, however, not been thoroughly analyzed. We used a combination of genetic inducible fate mapping and in vivo loss-of-function to analyze the requirement of Nkx6-2 in determining the fate of cortical interneurons. We have found that interneuron subtypes are born with a characteristic temporal pattern. Furthermore, we extend the characterization of interneurons from the Nkx6-2 lineage through the application of electrophysiological methods. Analysis of these populations in Nkx6-2 null mice suggests that there is a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons in the absence of Nkx6-2 gene function.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>19363146</pmid><doi>10.1093/cercor/bhp038</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Animals genetic fate mapping Homeodomain Proteins - metabolism interganglionic sulcus Interneurons - cytology Interneurons - physiology loss of function Mice Mice, Knockout mouse genetics Neocortex - cytology Neocortex - growth & development Tissue Distribution Transcription Factors - metabolism whole-cell physiology |
| title | Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages |
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