The relationship between symptom severity and regional cortical and grey matter volumes in schizophrenia
To investigate the relationship between symptom severity and cortical and grey matter volumes in schizophrenia. Fifty-three outpatients with schizophrenia were assessed by the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. Symptoms were grouped i...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2009-04, Vol.33 (3), p.482-490 |
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| creator | Nesvåg, Ragnar Saetre, Peter Lawyer, Glenn Jönsson, Erik G. Agartz, Ingrid |
| description | To investigate the relationship between symptom severity and cortical and grey matter volumes in schizophrenia.
Fifty-three outpatients with schizophrenia were assessed by the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. Symptoms were grouped into five factors (negative, relational, inattention, disorganization, and reality distortion). Cortical and lobar grey matter volumes within all regions of the brain were obtained from magnetic resonance images using two independent software tools. The relationships between brain volumes and symptom factors were analyzed by partial correlations controlling for age, gender, dose and type of antipsychotic medication, and intracranial volume.
Negative symptoms were generally associated with larger cortical volumes in all regions of the brain, and the relational and inattention factors were associated with larger frontal grey matter volumes. The reality distortion factor was associated with smaller cortical volumes throughout the brain and with smaller frontal and temporal grey matter volumes.
Differential contribution of positive and negative symptoms to variation in cortical and grey matter volumes indicates separate neurobiological mechanisms underlying the two major symptom domains in schizophrenia. |
| doi_str_mv | 10.1016/j.pnpbp.2009.01.013 |
| format | Article |
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Fifty-three outpatients with schizophrenia were assessed by the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. Symptoms were grouped into five factors (negative, relational, inattention, disorganization, and reality distortion). Cortical and lobar grey matter volumes within all regions of the brain were obtained from magnetic resonance images using two independent software tools. The relationships between brain volumes and symptom factors were analyzed by partial correlations controlling for age, gender, dose and type of antipsychotic medication, and intracranial volume.
Negative symptoms were generally associated with larger cortical volumes in all regions of the brain, and the relational and inattention factors were associated with larger frontal grey matter volumes. The reality distortion factor was associated with smaller cortical volumes throughout the brain and with smaller frontal and temporal grey matter volumes.
Differential contribution of positive and negative symptoms to variation in cortical and grey matter volumes indicates separate neurobiological mechanisms underlying the two major symptom domains in schizophrenia.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2009.01.013</identifier><identifier>PMID: 19439246</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Cerebral Cortex - pathology ; Female ; Functional Laterality - physiology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; MRI ; Negative symptoms ; Neuropharmacology ; Pharmacology. Drug treatments ; Positive symptoms ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - pathology ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Statistics as Topic ; Syndrome</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2009-04, Vol.33 (3), p.482-490</ispartof><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-4930d4ae8bd3336327819dac1e04ff700ccad34cfa00a9ca1423a91baefd46a73</citedby><cites>FETCH-LOGICAL-c456t-4930d4ae8bd3336327819dac1e04ff700ccad34cfa00a9ca1423a91baefd46a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278584609000177$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21384689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19439246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118656792$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nesvåg, Ragnar</creatorcontrib><creatorcontrib>Saetre, Peter</creatorcontrib><creatorcontrib>Lawyer, Glenn</creatorcontrib><creatorcontrib>Jönsson, Erik G.</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><title>The relationship between symptom severity and regional cortical and grey matter volumes in schizophrenia</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>To investigate the relationship between symptom severity and cortical and grey matter volumes in schizophrenia.
Fifty-three outpatients with schizophrenia were assessed by the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. Symptoms were grouped into five factors (negative, relational, inattention, disorganization, and reality distortion). Cortical and lobar grey matter volumes within all regions of the brain were obtained from magnetic resonance images using two independent software tools. The relationships between brain volumes and symptom factors were analyzed by partial correlations controlling for age, gender, dose and type of antipsychotic medication, and intracranial volume.
Negative symptoms were generally associated with larger cortical volumes in all regions of the brain, and the relational and inattention factors were associated with larger frontal grey matter volumes. The reality distortion factor was associated with smaller cortical volumes throughout the brain and with smaller frontal and temporal grey matter volumes.
Differential contribution of positive and negative symptoms to variation in cortical and grey matter volumes indicates separate neurobiological mechanisms underlying the two major symptom domains in schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - pathology</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Negative symptoms</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Positive symptoms</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Statistics as Topic</subject><subject>Syndrome</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhFyChXOCWxV-bjwMHVJWCVIlLOVsTZ9J4SeJgO1stv57ZblRuII3kV6NnRuP3Zeyt4FvBRfFxv52nuZm3kvN6ywWVesY2oiqrXEtRPGcbLknvKl1csFcx7jknhKuX7ELUWtVSFxvW3_WYBRwgOT_F3s1Zg-kBccricZyTH7OIBwwuHTOYWiLviYMhsz4kZ0mcuvcBj9kIKWHIDn5YRoyZow22d7_93AecHLxmLzoYIr5Z30v248v13dXX_Pb7zberz7e51bsi5bpWvNWAVdMqpQpFPxB1C1Yg111Xcm4ttErbDjiH2oLQUkEtGsCu1QWU6pLl573xAeelMXNwI4Sj8eDM2vpJCs1uVwklif9w5ufgfy0YkxldtDgMMKFfoilKqYUu9X9BSeYWVV0RqM6gDT7GgN3TDYKbU3Jmbx6TM6fkDBdUiqbereuXZsT278waFQHvVwAiGd8FmKyLT5wUioKuauI-nTkklw8Og4nW4WSxdQFtMq13_zzkD4dDuvk</recordid><startdate>20090430</startdate><enddate>20090430</enddate><creator>Nesvåg, Ragnar</creator><creator>Saetre, Peter</creator><creator>Lawyer, Glenn</creator><creator>Jönsson, Erik G.</creator><creator>Agartz, Ingrid</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20090430</creationdate><title>The relationship between symptom severity and regional cortical and grey matter volumes in schizophrenia</title><author>Nesvåg, Ragnar ; Saetre, Peter ; Lawyer, Glenn ; Jönsson, Erik G. ; Agartz, Ingrid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-4930d4ae8bd3336327819dac1e04ff700ccad34cfa00a9ca1423a91baefd46a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - pathology</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Negative symptoms</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Positive symptoms</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Statistics as Topic</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nesvåg, Ragnar</creatorcontrib><creatorcontrib>Saetre, Peter</creatorcontrib><creatorcontrib>Lawyer, Glenn</creatorcontrib><creatorcontrib>Jönsson, Erik G.</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nesvåg, Ragnar</au><au>Saetre, Peter</au><au>Lawyer, Glenn</au><au>Jönsson, Erik G.</au><au>Agartz, Ingrid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between symptom severity and regional cortical and grey matter volumes in schizophrenia</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2009-04-30</date><risdate>2009</risdate><volume>33</volume><issue>3</issue><spage>482</spage><epage>490</epage><pages>482-490</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>To investigate the relationship between symptom severity and cortical and grey matter volumes in schizophrenia.
Fifty-three outpatients with schizophrenia were assessed by the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. Symptoms were grouped into five factors (negative, relational, inattention, disorganization, and reality distortion). Cortical and lobar grey matter volumes within all regions of the brain were obtained from magnetic resonance images using two independent software tools. The relationships between brain volumes and symptom factors were analyzed by partial correlations controlling for age, gender, dose and type of antipsychotic medication, and intracranial volume.
Negative symptoms were generally associated with larger cortical volumes in all regions of the brain, and the relational and inattention factors were associated with larger frontal grey matter volumes. The reality distortion factor was associated with smaller cortical volumes throughout the brain and with smaller frontal and temporal grey matter volumes.
Differential contribution of positive and negative symptoms to variation in cortical and grey matter volumes indicates separate neurobiological mechanisms underlying the two major symptom domains in schizophrenia.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19439246</pmid><doi>10.1016/j.pnpbp.2009.01.013</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Cerebral Cortex - pathology Female Functional Laterality - physiology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged MRI Negative symptoms Neuropharmacology Pharmacology. Drug treatments Positive symptoms Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - pathology Schizophrenia - physiopathology Schizophrenic Psychology Statistics as Topic Syndrome |
| title | The relationship between symptom severity and regional cortical and grey matter volumes in schizophrenia |
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