Influence of androgen receptor repeat polymorphisms on personality traits in men
Background Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods We assessed and genotyped 141 me...
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| creator | Westberg, Lars, PhD Henningsson, Susanne, PhD Landén, Mikael, MD, PhD Annerbrink, Kristina, PhD Melke, Jonas, PhD Nilsson, Staffan, PhD Rosmond, Roland, MD, PhD Holm, Göran, MD, PhD Anckarsäter, Henrik, MD, PhD Eriksson, Elias, PhD |
| description | Background Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men. |
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The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.</description><identifier>ISSN: 1180-4882</identifier><identifier>ISSN: 1488-2434</identifier><identifier>EISSN: 1488-2434</identifier><identifier>PMID: 19448851</identifier><identifier>CODEN: JPNEEF</identifier><language>eng</language><publisher>Ottawa, ON: Canadian Medical Association</publisher><subject>Analysis of Variance ; Androgens ; Biological and medical sciences ; Clinical Medicine ; Farmaceutisk vetenskap ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Genetic polymorphisms ; Genotype ; Health aspects ; Humans ; Klinisk medicin ; Linkage Disequilibrium ; Male ; Medical and Health Sciences ; Medical Education ; Medical sciences ; Medicin och hälsovetenskap ; Men ; Personality ; Personality - genetics ; Personality Assessment ; Personality traits ; Pharmaceutical Sciences ; Phenotype ; Polymorphism ; Polymorphism, Genetic ; Psychiatry ; Psychoanalysis ; Psychological aspects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Psykiatri ; Receptors, Androgen - genetics ; Research Papers ; Sequence Analysis, DNA ; Trinucleotide Repeat Expansion ; Trinucleotide Repeats</subject><ispartof>Journal of psychiatry & neuroscience, 2009-05, Vol.34 (3), p.205-213</ispartof><rights>Canadian Medical Association</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 CMA Impact Inc.</rights><rights>Copyright Canadian Medical Association May 2009</rights><rights>2009 Canadian Medical Association 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674974/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674974/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21551140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19448851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/74296$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1427894$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118692074$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://research.chalmers.se/publication/74296$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Westberg, Lars, PhD</creatorcontrib><creatorcontrib>Henningsson, Susanne, PhD</creatorcontrib><creatorcontrib>Landén, Mikael, MD, PhD</creatorcontrib><creatorcontrib>Annerbrink, Kristina, PhD</creatorcontrib><creatorcontrib>Melke, Jonas, PhD</creatorcontrib><creatorcontrib>Nilsson, Staffan, PhD</creatorcontrib><creatorcontrib>Rosmond, Roland, MD, PhD</creatorcontrib><creatorcontrib>Holm, Göran, MD, PhD</creatorcontrib><creatorcontrib>Anckarsäter, Henrik, MD, PhD</creatorcontrib><creatorcontrib>Eriksson, Elias, PhD</creatorcontrib><title>Influence of androgen receptor repeat polymorphisms on personality traits in men</title><title>Journal of psychiatry & neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Background Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.</description><subject>Analysis of Variance</subject><subject>Androgens</subject><subject>Biological and medical sciences</subject><subject>Clinical Medicine</subject><subject>Farmaceutisk vetenskap</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Klinisk medicin</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical Education</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Men</subject><subject>Personality</subject><subject>Personality - genetics</subject><subject>Personality Assessment</subject><subject>Personality traits</subject><subject>Pharmaceutical Sciences</subject><subject>Phenotype</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Psychiatry</subject><subject>Psychoanalysis</subject><subject>Psychological aspects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Psykiatri</subject><subject>Receptors, Androgen - genetics</subject><subject>Research Papers</subject><subject>Sequence Analysis, DNA</subject><subject>Trinucleotide Repeat Expansion</subject><subject>Trinucleotide Repeats</subject><issn>1180-4882</issn><issn>1488-2434</issn><issn>1488-2434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqVlF1r2zAUhs3YWLtuf2GYwQqDZejLlnQzKGUfhbCNdbsWsnWUqLUlV7K75d9PadOmgeZiGOHj4-d9OdKR9KQ4xEyIGWGUPc0xFmiWv8lB8SKlC4QQQbh6XhxgyXK6wofFjzNvuwl8C2WwpfYmhgX4MkILwxhiDgbQYzmEbtWHOCxd6lMZfDlATMHrzo2rcozajal0vuzBvyyeWd0leLV5HxW_P3_6dfp1Nv_-5ez0ZD4DweQ4M5RRq5nhwkjTAK1Ng6itwNRYYGGtxhWvOAUijaYItJBU0prrllBhGszpUTG79U1_YJgaNUTX67hSQTu1SV3mCFRVCVTjzJ_v5SMk0LFdqnapuz7PbK2rpcGGUKI4bahiXEgla8uV5LghxOraiDq7yr2uQwxmW8pdObkntSSIs6yd79V205BHk8daQ5qWYW2tskQ0imGKlWiMVYZJ2SCLrRFru_d77RbZLqcWN26cEbmu_OMtntkeTAs-t7HbncDOH--WahGuFak5kzflv9kYxHA1QRrVRZhi3hJJEcyJxJSibZcWugPlvA3Zq807DLJl8GBdTp9gKTEheXNuTXf4dnBX6iH04REoPwZ61z7q-m5HkJkR_o4LPaWkzs5__gf7bZc9fsAuQXfjMoVuGl3waRd8_XCx71f57hxm4O0G0KnVnY3aty7dcwRXFcYMbbsG-WhdO4iq7Zx3WXIJK0j3HcAqEYXU-foGWF8ASFYIUV7Tf6lMUGI</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Westberg, Lars, PhD</creator><creator>Henningsson, Susanne, PhD</creator><creator>Landén, Mikael, MD, PhD</creator><creator>Annerbrink, Kristina, PhD</creator><creator>Melke, Jonas, PhD</creator><creator>Nilsson, Staffan, PhD</creator><creator>Rosmond, Roland, MD, PhD</creator><creator>Holm, Göran, MD, PhD</creator><creator>Anckarsäter, Henrik, MD, PhD</creator><creator>Eriksson, Elias, PhD</creator><general>Canadian Medical Association</general><general>CMA Impact Inc</general><general>CMA Impact, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>D95</scope><scope>F1S</scope></search><sort><creationdate>20090501</creationdate><title>Influence of androgen receptor repeat polymorphisms on personality traits in men</title><author>Westberg, Lars, PhD ; Henningsson, Susanne, PhD ; Landén, Mikael, MD, PhD ; Annerbrink, Kristina, PhD ; Melke, Jonas, PhD ; Nilsson, Staffan, PhD ; Rosmond, Roland, MD, PhD ; Holm, Göran, MD, PhD ; Anckarsäter, Henrik, MD, PhD ; Eriksson, Elias, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e849t-d343fa4d78d9dbe36db03f5ed61818ffa157573e29da30ea8939367ac238db173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analysis of Variance</topic><topic>Androgens</topic><topic>Biological and medical sciences</topic><topic>Clinical Medicine</topic><topic>Farmaceutisk vetenskap</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genotype</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Klinisk medicin</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical Education</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Men</topic><topic>Personality</topic><topic>Personality - genetics</topic><topic>Personality Assessment</topic><topic>Personality traits</topic><topic>Pharmaceutical Sciences</topic><topic>Phenotype</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Psychiatry</topic><topic>Psychoanalysis</topic><topic>Psychological aspects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Psykiatri</topic><topic>Receptors, Androgen - genetics</topic><topic>Research Papers</topic><topic>Sequence Analysis, DNA</topic><topic>Trinucleotide Repeat Expansion</topic><topic>Trinucleotide Repeats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westberg, Lars, PhD</creatorcontrib><creatorcontrib>Henningsson, Susanne, PhD</creatorcontrib><creatorcontrib>Landén, Mikael, MD, PhD</creatorcontrib><creatorcontrib>Annerbrink, Kristina, PhD</creatorcontrib><creatorcontrib>Melke, Jonas, PhD</creatorcontrib><creatorcontrib>Nilsson, Staffan, PhD</creatorcontrib><creatorcontrib>Rosmond, Roland, MD, PhD</creatorcontrib><creatorcontrib>Holm, Göran, MD, PhD</creatorcontrib><creatorcontrib>Anckarsäter, Henrik, MD, PhD</creatorcontrib><creatorcontrib>Eriksson, Elias, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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tekniska högskola</collection><jtitle>Journal of psychiatry & neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westberg, Lars, PhD</au><au>Henningsson, Susanne, PhD</au><au>Landén, Mikael, MD, PhD</au><au>Annerbrink, Kristina, PhD</au><au>Melke, Jonas, PhD</au><au>Nilsson, Staffan, PhD</au><au>Rosmond, Roland, MD, PhD</au><au>Holm, Göran, MD, PhD</au><au>Anckarsäter, Henrik, MD, PhD</au><au>Eriksson, Elias, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of androgen receptor repeat polymorphisms on personality traits in men</atitle><jtitle>Journal of psychiatry & neuroscience</jtitle><addtitle>J Psychiatry Neurosci</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>34</volume><issue>3</issue><spage>205</spage><epage>213</epage><pages>205-213</pages><issn>1180-4882</issn><issn>1488-2434</issn><eissn>1488-2434</eissn><coden>JPNEEF</coden><abstract>Background Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.</abstract><cop>Ottawa, ON</cop><pub>Canadian Medical Association</pub><pmid>19448851</pmid><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis of Variance Androgens Biological and medical sciences Clinical Medicine Farmaceutisk vetenskap Fundamental and applied biological sciences. Psychology Genetic aspects Genetic polymorphisms Genotype Health aspects Humans Klinisk medicin Linkage Disequilibrium Male Medical and Health Sciences Medical Education Medical sciences Medicin och hälsovetenskap Men Personality Personality - genetics Personality Assessment Personality traits Pharmaceutical Sciences Phenotype Polymorphism Polymorphism, Genetic Psychiatry Psychoanalysis Psychological aspects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Psykiatri Receptors, Androgen - genetics Research Papers Sequence Analysis, DNA Trinucleotide Repeat Expansion Trinucleotide Repeats |
| title | Influence of androgen receptor repeat polymorphisms on personality traits in men |
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