The pathology of Wilms' tumour (nephroblastoma): the International Society of Paediatric Oncology approach
In the International Society of Paediatric Oncology renal tumour trials, preoperative chemotherapy has been successfully applied with resulting reduction of tumour rupture and increased favourable stage distribution of nephroblastoma. Postoperative treatment includes chemotherapy and sometimes radio...
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| Veröffentlicht in: | Journal of clinical pathology 2010-02, Vol.63 (2), p.102-109 |
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| description | In the International Society of Paediatric Oncology renal tumour trials, preoperative chemotherapy has been successfully applied with resulting reduction of tumour rupture and increased favourable stage distribution of nephroblastoma. Postoperative treatment includes chemotherapy and sometimes radiotherapy in a risk-adapted approach based on histological sub-classification and stage of the tumour. However, preoperative chemotherapy alters the tumour's histological features and distribution of subtypes, and makes staging more difficult. The paper highlights the most common practical diagnostic difficulties that a pathologist is faced with in dealing with pretreated nephroblastomas. It emphasises the importance of a systematic, step-by-step analysis based on adequately sampled material, in order to accurately sub-classify a nephroblastoma as a low, intermediate or high risk tumour and assign its genuine stage. Finally, it outlines the standard operating procedure for submission of renal tumours for rapid central pathology review which allows the treating oncologists to apply the optimal treatment protocol. |
| doi_str_mv | 10.1136/jcp.2009.064600 |
| format | Article |
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Postoperative treatment includes chemotherapy and sometimes radiotherapy in a risk-adapted approach based on histological sub-classification and stage of the tumour. However, preoperative chemotherapy alters the tumour's histological features and distribution of subtypes, and makes staging more difficult. The paper highlights the most common practical diagnostic difficulties that a pathologist is faced with in dealing with pretreated nephroblastomas. It emphasises the importance of a systematic, step-by-step analysis based on adequately sampled material, in order to accurately sub-classify a nephroblastoma as a low, intermediate or high risk tumour and assign its genuine stage. 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Urinary tract diseases ; Oncology ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. 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Postoperative treatment includes chemotherapy and sometimes radiotherapy in a risk-adapted approach based on histological sub-classification and stage of the tumour. However, preoperative chemotherapy alters the tumour's histological features and distribution of subtypes, and makes staging more difficult. The paper highlights the most common practical diagnostic difficulties that a pathologist is faced with in dealing with pretreated nephroblastomas. It emphasises the importance of a systematic, step-by-step analysis based on adequately sampled material, in order to accurately sub-classify a nephroblastoma as a low, intermediate or high risk tumour and assign its genuine stage. Finally, it outlines the standard operating procedure for submission of renal tumours for rapid central pathology review which allows the treating oncologists to apply the optimal treatment protocol.</description><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Child</subject><subject>Classification</subject><subject>Collaboration</subject><subject>Gangrene</subject><subject>Histology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney Neoplasms - drug therapy</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Kidneys</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Nephrectomy</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Radiation therapy</subject><subject>Society</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Wilms Tumor - drug therapy</subject><subject>Wilms Tumor - pathology</subject><subject>Wilms Tumor - surgery</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1v1DAUxCMEotvCmRuKhFABKVs_27ETbmjFR9kVRaIsR8vxOqzTJA62o9L_Hi-JthIXTrbs34zmvUmSZ4CWAIRdNGpYYoTKJWKUIfQgWQDlOKNA2cNkgRCGrOSUnSSn3jcIAeFAHicnULKCI8CLpLne63SQYW9b-_MutXX6w7SdP0_D2NnRpa96PeydrVrpg-3k67dpiILLPmjXy2BsL9v0m1VGh7_ir1LvjAzOqPSqV5OnHAZnpdo_SR7VsvX66XyeJd8_vL9efco2Vx8vV-82WZUjFjLNgZY1SEwIrxnoOBCp6x0HxnldsRoD1gXSOcNYYUYAsZLKXDOyqxhQkpOzJJt8_a0exkoMznTS3QkrjZifbuJNizxnFNHIn098jPlr1D6Iznil21b22o5ecEIILQg6OL_4h2zijuIKvABeACo5Lg7UxUQpZ713uj4mACQOrYnYmji0JqbWouL57DtWnd7d83NNEXg5A9Ir2dZO9sr4I4cx4bSk6H5044P-ffyX7kYwTnguvmxXYr3ewuftmohN5N9MfNU1_035B1AxuyI</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Vujanić, G M</creator><creator>Sandstedt, B</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20100201</creationdate><title>The pathology of Wilms' tumour (nephroblastoma): the International Society of Paediatric Oncology approach</title><author>Vujanić, G M ; Sandstedt, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-e7149f1a2337f61e1473ffd71677fb6f212e80e5622c26310694a5e63db614353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Child</topic><topic>Classification</topic><topic>Collaboration</topic><topic>Gangrene</topic><topic>Histology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidney Neoplasms - drug therapy</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Kidneys</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>Nephrectomy</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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| source | MEDLINE; BMJ Journals - NESLi2; PubMed Central |
| subjects | Biological and medical sciences Chemotherapy Chemotherapy, Adjuvant Child Classification Collaboration Gangrene Histology Humans Investigative techniques, diagnostic techniques (general aspects) Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology Kidney Neoplasms - surgery Kidneys Lymphatic system Medical prognosis Medical sciences Neoplasm Staging Nephrectomy Nephrology. Urinary tract diseases Oncology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Radiation therapy Society Surgery Tumors Tumors of the urinary system Wilms Tumor - drug therapy Wilms Tumor - pathology Wilms Tumor - surgery |
| title | The pathology of Wilms' tumour (nephroblastoma): the International Society of Paediatric Oncology approach |
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