The allogeneic graft‐versus‐cancer effect

Summary Allogeneic haematological stem cell transplantation (HSCT) has developed into immunotherapy. Donor CD4+, CD8+ and natural killer (NK) cells have been reported to mediate graft‐versus‐leukaemia (GVL) effects, using Fas‐dependent killing and perforin degranulation to eradicate malignant cells....

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Veröffentlicht in:	British journal of haematology 2009-12, Vol.147 (5), p.614-633
Hauptverfasser:	Ringdén, Olle, Karlsson, Helen, Olsson, Richard, Omazic, Brigitta, Uhlin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences bone marrow transplantation immunology Graft vs Leukemia Effect - immunology Graft vs Tumor Effect - immunology haematopoetic stem cell transplantation Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - trends Humans Killer Cells, Natural - immunology Medical sciences Medicin och hälsovetenskap Neoplasms - immunology Neoplasms - therapy T-Lymphocytes, Cytotoxic - immunology Treatment Outcome
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