Progressive Multifocal Leukoencephalopathy after Natalizumab Monotherapy

This report describes progressive multifocal leukoencephalopathy in a patient who was receiving natalizumab therapy for multiple sclerosis. Plasma exchange was used to accelerate the clearance of natalizumab. Three weeks after plasma exchange, the patient's condition worsened neurologically bec...

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Veröffentlicht in:	The New England journal of medicine 2009-09, Vol.361 (11), p.1081-1087
Hauptverfasser:	Lindå, Hans, von Heijne, Anders, Major, Eugene O, Ryschkewitsch, Caroline, Berg, Johan, Olsson, Tomas, Martin, Claes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Biological and medical sciences Brain - pathology DNA, Viral - blood General aspects Human viral diseases Humans Immune Reconstitution Inflammatory Syndrome - etiology Infectious diseases Integrin alpha4 - immunology JC Virus - genetics JC Virus - immunology Leukoencephalopathy, Progressive Multifocal - chemically induced Leukoencephalopathy, Progressive Multifocal - immunology Magnetic Resonance Imaging Male Medical sciences Medicin och hälsovetenskap Multiple Sclerosis - complications Multiple Sclerosis - drug therapy Multiple Sclerosis - pathology Natalizumab Polymerase Chain Reaction Viral diseases Viral diseases of the nervous system
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