Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea
The objective of our study was to determine the prevalence of anti‐infectious agent antibodies and autoantibodies in a unique non‐Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2009-09, Vol.1173 (1), p.675-682 |
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| creator | Agmon-Levin, Nancy Bat-sheva, Porat Katz Barzilai, Ori Ram, Maya Lindeberg, Staffan Frostegård, Johan Shoenfeld, Yehuda |
| description | The objective of our study was to determine the prevalence of anti‐infectious agent antibodies and autoantibodies in a unique non‐Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti‐infectious agent antibodies (treponema, toxoplsmosis, Epstein–Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti‐double‐stranded (ds)DNA, anti‐chromatin, anti‐ribonucleoprotein (RNP), anti‐SSB, anti‐SSA, anti‐Scl‐70, anti‐Smith, anti‐centromer, anti‐SmRNP, anti‐Jo‐1, and anti‐ribosomal‐P] using the Bio‐Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0–6% of controls (P < 0.0001). Anti‐dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups ( |
| doi_str_mv | 10.1111/j.1749-6632.2009.04671.x |
| format | Article |
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We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti‐infectious agent antibodies (treponema, toxoplsmosis, Epstein–Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti‐double‐stranded (ds)DNA, anti‐chromatin, anti‐ribonucleoprotein (RNP), anti‐SSB, anti‐SSA, anti‐Scl‐70, anti‐Smith, anti‐centromer, anti‐SmRNP, anti‐Jo‐1, and anti‐ribosomal‐P] using the Bio‐Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0–6% of controls (P < 0.0001). Anti‐dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (<10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM‐antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross‐react with the pathogenic anti‐dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies.</description><identifier>ISSN: 0077-8923</identifier><identifier>ISSN: 1749-6632</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/j.1749-6632.2009.04671.x</identifier><identifier>PMID: 19758215</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Analysis of Variance ; Animals ; Annan klinisk medicin ; Antibodies ; Antibodies, Antinuclear - blood ; Antibodies, Bacterial - blood ; antiphosphorylcholine antibodies ; atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - epidemiology ; Atherosclerosis - immunology ; autoantibodies ; Autoantibodies - blood ; Bacterial Infections - immunology ; Bio-plex ; Chi-Square Distribution ; Clinical Medicine ; Cytomegalovirus ; Cytomegalovirus - immunology ; Diets ; Epstein-Barr virus ; Herpesviridae ; Herpesvirus 4, Human - immunology ; Immunoassay - methods ; Kitava ; Klinisk medicin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; New Guinea ; Other Clinical Medicine ; Papua New Guinea ; Papua New Guinea - epidemiology ; Protective ; Rubella ; Rubella virus - immunology ; Seroepidemiologic Studies ; Toxoplasma - immunology ; Toxoplasmosis - immunology ; Treponema ; Treponema - immunology ; Virus Diseases - immunology ; Viruses ; yaws disease</subject><ispartof>Annals of the New York Academy of Sciences, 2009-09, Vol.1173 (1), p.675-682</ispartof><rights>2009 New York Academy of Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6911-e394b4635f8c2a8893b37d593d872ed127ed86c1ab76bb2030ac517f511821bb3</citedby><cites>FETCH-LOGICAL-c6911-e394b4635f8c2a8893b37d593d872ed127ed86c1ab76bb2030ac517f511821bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1749-6632.2009.04671.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1749-6632.2009.04671.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,309,310,314,780,784,789,790,885,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19758215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1507052$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:119484613$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Agmon-Levin, Nancy</creatorcontrib><creatorcontrib>Bat-sheva, Porat Katz</creatorcontrib><creatorcontrib>Barzilai, Ori</creatorcontrib><creatorcontrib>Ram, Maya</creatorcontrib><creatorcontrib>Lindeberg, Staffan</creatorcontrib><creatorcontrib>Frostegård, Johan</creatorcontrib><creatorcontrib>Shoenfeld, Yehuda</creatorcontrib><title>Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>The objective of our study was to determine the prevalence of anti‐infectious agent antibodies and autoantibodies in a unique non‐Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti‐infectious agent antibodies (treponema, toxoplsmosis, Epstein–Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti‐double‐stranded (ds)DNA, anti‐chromatin, anti‐ribonucleoprotein (RNP), anti‐SSB, anti‐SSA, anti‐Scl‐70, anti‐Smith, anti‐centromer, anti‐SmRNP, anti‐Jo‐1, and anti‐ribosomal‐P] using the Bio‐Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0–6% of controls (P < 0.0001). Anti‐dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (<10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM‐antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross‐react with the pathogenic anti‐dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Annan klinisk medicin</subject><subject>Antibodies</subject><subject>Antibodies, Antinuclear - blood</subject><subject>Antibodies, Bacterial - blood</subject><subject>antiphosphorylcholine antibodies</subject><subject>atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - epidemiology</subject><subject>Atherosclerosis - immunology</subject><subject>autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Bacterial Infections - immunology</subject><subject>Bio-plex</subject><subject>Chi-Square Distribution</subject><subject>Clinical Medicine</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - immunology</subject><subject>Diets</subject><subject>Epstein-Barr virus</subject><subject>Herpesviridae</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Immunoassay - methods</subject><subject>Kitava</subject><subject>Klinisk medicin</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>New Guinea</subject><subject>Other Clinical Medicine</subject><subject>Papua New Guinea</subject><subject>Papua New Guinea - epidemiology</subject><subject>Protective</subject><subject>Rubella</subject><subject>Rubella virus - immunology</subject><subject>Seroepidemiologic Studies</subject><subject>Toxoplasma - immunology</subject><subject>Toxoplasmosis - immunology</subject><subject>Treponema</subject><subject>Treponema - immunology</subject><subject>Virus Diseases - immunology</subject><subject>Viruses</subject><subject>yaws disease</subject><issn>0077-8923</issn><issn>1749-6632</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuP0zAUhSMEYsrAX0BeITYpfsSvDVIpTEFUZaQpQqwsO3bAnTTpxAltt_xynElpV0OJ5Ng3_s65ytVJEoDgGMXnzWqMeCZTxggeYwjlGGaMo_HuUTI6XjxORhByngqJyUXyLIQVhAiLjD9NLpDkVGBER8nvSdX6tnGbunJrXYK-NLX1LoC509ZXP0Bbg0nX1nq42YPrprZd3vq6Arqyfdm6oSyaeg0m7U_X1CEv-7cPwFfgs2_1L12FAbjWm06DhduCWecrp58nTwpdBvfisF8mX68-LKcf0_mX2afpZJ7mTCKUOiIzkzFCC5FjLYQkhnBLJbGCY2cR5s4KliNtODMGQwJ1ThEvKELxV40hl0k6-Iat23RGbRq_1s1e1dqrw6fbeHKKUiq4iLx8kN_EGZxEf4UIyUxkDJGonT-oLbtNXCau-2bSUlpYowoOucow1spkplCGOuxySJ1ENtq9Guxi37vOhVatfchdWerK1V1QjDNK4kTOgiQTkjOBz4IYChIzQiP4-p8gEhBmgnEBz6MRohjHEEZUDGgeQxIaVxwnhKDqI65Wqk-y6pOs-oir-4irXZS-PHTpzNrZk_CQ6Qi8HYCtL93-v43V4vvkpj-eguJD63ZHA93cxkHHqahvi5m6mV4t2RK9V-_IH7igG_U</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Agmon-Levin, Nancy</creator><creator>Bat-sheva, Porat Katz</creator><creator>Barzilai, Ori</creator><creator>Ram, Maya</creator><creator>Lindeberg, Staffan</creator><creator>Frostegård, Johan</creator><creator>Shoenfeld, Yehuda</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>SOI</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7QL</scope><scope>7QO</scope><scope>7U9</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>ADTPV</scope><scope>BNKNJ</scope><scope>D95</scope><scope>AOWAS</scope></search><sort><creationdate>200909</creationdate><title>Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea</title><author>Agmon-Levin, Nancy ; 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We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti‐infectious agent antibodies (treponema, toxoplsmosis, Epstein–Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti‐double‐stranded (ds)DNA, anti‐chromatin, anti‐ribonucleoprotein (RNP), anti‐SSB, anti‐SSA, anti‐Scl‐70, anti‐Smith, anti‐centromer, anti‐SmRNP, anti‐Jo‐1, and anti‐ribosomal‐P] using the Bio‐Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0–6% of controls (P < 0.0001). Anti‐dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (<10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM‐antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross‐react with the pathogenic anti‐dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19758215</pmid><doi>10.1111/j.1749-6632.2009.04671.x</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2009-09, Vol.1173 (1), p.675-682 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Analysis of Variance Animals Annan klinisk medicin Antibodies Antibodies, Antinuclear - blood Antibodies, Bacterial - blood antiphosphorylcholine antibodies atherosclerosis Atherosclerosis - blood Atherosclerosis - epidemiology Atherosclerosis - immunology autoantibodies Autoantibodies - blood Bacterial Infections - immunology Bio-plex Chi-Square Distribution Clinical Medicine Cytomegalovirus Cytomegalovirus - immunology Diets Epstein-Barr virus Herpesviridae Herpesvirus 4, Human - immunology Immunoassay - methods Kitava Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap New Guinea Other Clinical Medicine Papua New Guinea Papua New Guinea - epidemiology Protective Rubella Rubella virus - immunology Seroepidemiologic Studies Toxoplasma - immunology Toxoplasmosis - immunology Treponema Treponema - immunology Virus Diseases - immunology Viruses yaws disease |
| title | Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea |
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