Working memory plasticity modulated by dopamine transporter genotype
Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group...
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| Veröffentlicht in: | Neuroscience letters 2009-12, Vol.467 (2), p.117-120 |
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| creator | Brehmer, Yvonne Westerberg, Helena Bellander, Martin Fürth, Daniel Karlsson, Sari Bäckman, Lars |
| description | Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received 4 weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores. |
| doi_str_mv | 10.1016/j.neulet.2009.10.018 |
| format | Article |
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Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received 4 weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. 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Psychology ; Genotype ; Heterozygote ; Humans ; Male ; Medicin och hälsovetenskap ; Memory, Short-Term - physiology ; Neuronal Plasticity - physiology ; Plasticity ; Polymorphism, Genetic ; Spatial Behavior ; Training ; Verbal Behavior ; Vertebrates: nervous system and sense organs ; Working memory ; Young Adult</subject><ispartof>Neuroscience letters, 2009-12, Vol.467 (2), p.117-120</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-e0da9a701b8ad13be31abfc236c24ace3c2eec66be6579e3eb8f95f41e5f676d3</citedby><cites>FETCH-LOGICAL-c511t-e0da9a701b8ad13be31abfc236c24ace3c2eec66be6579e3eb8f95f41e5f676d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2009.10.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22154986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19819301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:119650945$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Brehmer, Yvonne</creatorcontrib><creatorcontrib>Westerberg, Helena</creatorcontrib><creatorcontrib>Bellander, Martin</creatorcontrib><creatorcontrib>Fürth, Daniel</creatorcontrib><creatorcontrib>Karlsson, Sari</creatorcontrib><creatorcontrib>Bäckman, Lars</creatorcontrib><title>Working memory plasticity modulated by dopamine transporter genotype</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received 4 weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cognitive ability</subject><subject>Dopamine Plasma Membrane Transport Proteins - genetics</subject><subject>Dopamine transporter polymorphism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Genotype</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Memory, Short-Term - physiology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Plasticity</topic><topic>Polymorphism, Genetic</topic><topic>Spatial Behavior</topic><topic>Training</topic><topic>Verbal Behavior</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Working memory</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brehmer, Yvonne</creatorcontrib><creatorcontrib>Westerberg, Helena</creatorcontrib><creatorcontrib>Bellander, Martin</creatorcontrib><creatorcontrib>Fürth, Daniel</creatorcontrib><creatorcontrib>Karlsson, Sari</creatorcontrib><creatorcontrib>Bäckman, Lars</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brehmer, Yvonne</au><au>Westerberg, Helena</au><au>Bellander, Martin</au><au>Fürth, Daniel</au><au>Karlsson, Sari</au><au>Bäckman, Lars</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Working memory plasticity modulated by dopamine transporter genotype</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-12-25</date><risdate>2009</risdate><volume>467</volume><issue>2</issue><spage>117</spage><epage>120</epage><pages>117-120</pages><issn>0304-3940</issn><issn>1872-7972</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received 4 weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19819301</pmid><doi>10.1016/j.neulet.2009.10.018</doi><tpages>4</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Biological and medical sciences Cognitive ability Dopamine Plasma Membrane Transport Proteins - genetics Dopamine transporter polymorphism Female Fundamental and applied biological sciences. Psychology Genotype Heterozygote Humans Male Medicin och hälsovetenskap Memory, Short-Term - physiology Neuronal Plasticity - physiology Plasticity Polymorphism, Genetic Spatial Behavior Training Verbal Behavior Vertebrates: nervous system and sense organs Working memory Young Adult |
| title | Working memory plasticity modulated by dopamine transporter genotype |
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