Natural killer cells in human autoimmunity
Natural killer (NK) cells are innate immune cells. Although NK cells are best characterized for their ability to control tumors and infections, recent data have indicated that they also are important regulatory cells by virtue of interactions with many types of immune and nonimmune cells. Thereby, t...
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| Veröffentlicht in: | Current opinion in immunology 2009-12, Vol.21 (6), p.634-640 |
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| container_title | Current opinion in immunology |
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| creator | Flodström-Tullberg, Malin Bryceson, Yenan T Shi, Fu-Dong Höglund, Petter Ljunggren, Hans-Gustaf |
| description | Natural killer (NK) cells are innate immune cells. Although NK cells are best characterized for their ability to control tumors and infections, recent data have indicated that they also are important regulatory cells by virtue of interactions with many types of immune and nonimmune cells. Thereby, they can affect the outcome of adaptive immune responses and maintain immune homeostasis. Thus, NK cells can either exacerbate or limit immune responses, including those to autoantigens. Here, we discuss current insights into the role of NK cells in human autoimmunity. |
| doi_str_mv | 10.1016/j.coi.2009.09.012 |
| format | Article |
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| identifier | ISSN: 0952-7915 |
| ispartof | Current opinion in immunology, 2009-12, Vol.21 (6), p.634-640 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Allergy and Immunology Animals Autoimmune Diseases - immunology Autoimmune Diseases - therapy Autoimmunity Homeostasis Humans Immunity, Innate Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Medicin och hälsovetenskap |
| title | Natural killer cells in human autoimmunity |
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