Nogo receptor 1 regulates formation of lasting memories

Formation of lasting memories is believed to rely on structural alterations at the synaptic level. We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of lasting...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (48), p.20476-20481
Hauptverfasser:	Karlén, Alexandra, Karlsson, Tobias E, Mattsson, Anna, Lundströmer, Karin, Codeluppi, Simone, Pham, Therese M, Bäckman, Cristina M, Ögren, Sven Ove, Åberg, Elin, Hoffman, Alexander F, Sherling, Michael A, Lupica, Carl R, Hoffer, Barry J, Spenger, Christian, Josephson, Anna, Brené, Stefan, Olson, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain Brain-Derived Neurotrophic Factor - metabolism Chromatography, High Pressure Liquid Down regulation Electrophysiology Gene expression Gene Expression Regulation - physiology Immunoblotting Immunohistochemistry In Situ Hybridization Long term potentiation Maze Learning - physiology Mazes Membrane Proteins - metabolism Memory Memory - physiology Messenger RNA Mice Mice, Transgenic Myelin Proteins - metabolism Myelin Proteins - physiology Nerve Tissue Proteins - metabolism Neurons Nogo Proteins Prosencephalon - metabolism Receptors Receptors, Tumor Necrosis Factor - metabolism Ribonucleic acid RNA Rodents Rotarod Performance Test Transgenes Transgenes - genetics Transgenic animals
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