Heparan Sulfation–Dependent Fibroblast Growth Factor Signaling Maintains Embryonic Stem Cells Primed for Differentiation in a Heterogeneous State

Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous leukemia inhibitory factor and BMP4 perpetuate a pluripotent state, less is known about the factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critica...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2010-02, Vol.28 (2), p.191-200
Hauptverfasser:	Lanner, Fredrik, Lee, Kian Leong, Sohl, Marcus, Holmborn, Katarina, Yang, Henry, Wilbertz, Johannes, Poellinger, Lorenz, Rossant, Janet, Farnebo, Filip
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - genetics Amidohydrolases - metabolism Animals Blotting, Western Cell Differentiation - drug effects Cell Differentiation - genetics Cell Differentiation - physiology Cell Line, Tumor Chlorates - pharmacology Differentiation Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Flow Cytometry Fluorescent Antibody Technique Heparin Heparitin Sulfate - metabolism Homeodomain Proteins - metabolism Kruppel-Like Transcription Factors - metabolism MEDICIN MEDICINE Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Nanog Homeobox Protein Octamer Transcription Factor-3 - metabolism Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Self-renewal Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology Sulfotransferases - genetics Sulfotransferases - metabolism
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