Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients
Objective High titers of specific anti–citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well‐define...
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| creator | Snir, Omri Widhe, Mona Hermansson, Monika von Spee, Caroline Lindberg, Johan Hensen, Sanne Lundberg, Karin Engström, Åke Venables, Patrick J. W. Toes, René E. M. Holmdahl, Rikard Klareskog, Lars Malmström, Vivianne |
| description | Objective
High titers of specific anti–citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well‐defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA‐specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well‐defined HLA–DR groups.
Methods
Paired serum and synovial fluid samples from 290 RA patients and serum samples from 100 age‐ and sex‐matched healthy controls were analyzed for the presence of anti‐MCV and anti‐CCP antibodies and for reactivity to citrullinated fibrinogen, α‐enolase, type II collagen, and vimentin. A total of 219 of the 290 patients were genotyped for the HLA–DR shared epitope alleles.
Results
Significantly higher proportions of antibodies against all RA‐associated citrullinated antigens were found in synovial fluid as compared with serum. This was also true for the MCV and CCP responses but not for non–RA‐associated anti–tetanus toxoid antibodies. As expected, we found a high correlation between citrullinated vimentin and MCV responses. All synovial fluid ACPAs were predominantly associated with HLA–DRB1*04 alleles and were confined to the CCP+/MCV+ subset of patients.
Conclusion
MCV and CCP positivity represent a similar subset of RA patients, whereas ACPAs with different fine specificities fall into subgroups of anti‐CCP+/anti‐MCV+ patients. The levels of all specific ACPAs were elevated in synovial fluid, suggesting that there is local antibody production and/or retention of ACPAs at the site of inflammation governed by RA‐predisposing genes. |
| doi_str_mv | 10.1002/art.25036 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_553943</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733694968</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6146-88c438305a31e715b82eb6713e7ce27c4626a6644d9451fd28e07fc8d03266e13</originalsourceid><addsrcrecordid>eNqN0ltrFDEUB_Agil1XH_wCkhcpgtPmPpPHpdYLFASpvoZs5kwn7exkTTKWfvtmnW37tOhTLvz-Scg5CL2l5IQSwk5tzCdMEq6eoQWVTFeEcvocLQghouJS0yP0KqXrsmRc8pfoiBHCteBsgfrVmP06tB4SzgEn-APRDtj5HKdh8KPN0GJbzBWMCdsIGMboXV92_YhzD_g6-DEnHDoce5g2NgdfEjH30Wef8NZmDwW8Ri86OyR4sx-X6Ofn88uzr9XF9y_fzlYXlVNUqKppnOANJ9JyCjWV64bBWtWUQ-2A1U4opqxSQrRaSNq1rAFSd65pCWdKAeVLVM3nplvYTmuzjX5j450J1pv91k2ZgZFy9wXF64N-G0P7FHoIUkY0bWomS_bjwewn_2tlQrwy02SoKF-v_4_f5N6welfNJTqeeXnG7wlSNhufHAyDHSFMydRC6iJr9m_JudJCq6bID7N0MaQUoXt8BCVm10umVM787aVi3-1PndYbaB_lQ_MU8H4PbHJ26KIdnU9PjnFelyoVdzq7Wz_A3eEbzerH5Xz1PRn94cw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733694968</pqid></control><display><type>article</type><title>Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Snir, Omri ; Widhe, Mona ; Hermansson, Monika ; von Spee, Caroline ; Lindberg, Johan ; Hensen, Sanne ; Lundberg, Karin ; Engström, Åke ; Venables, Patrick J. W. ; Toes, René E. M. ; Holmdahl, Rikard ; Klareskog, Lars ; Malmström, Vivianne</creator><creatorcontrib>Snir, Omri ; Widhe, Mona ; Hermansson, Monika ; von Spee, Caroline ; Lindberg, Johan ; Hensen, Sanne ; Lundberg, Karin ; Engström, Åke ; Venables, Patrick J. W. ; Toes, René E. M. ; Holmdahl, Rikard ; Klareskog, Lars ; Malmström, Vivianne</creatorcontrib><description>Objective
High titers of specific anti–citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well‐defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA‐specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well‐defined HLA–DR groups.
Methods
Paired serum and synovial fluid samples from 290 RA patients and serum samples from 100 age‐ and sex‐matched healthy controls were analyzed for the presence of anti‐MCV and anti‐CCP antibodies and for reactivity to citrullinated fibrinogen, α‐enolase, type II collagen, and vimentin. A total of 219 of the 290 patients were genotyped for the HLA–DR shared epitope alleles.
Results
Significantly higher proportions of antibodies against all RA‐associated citrullinated antigens were found in synovial fluid as compared with serum. This was also true for the MCV and CCP responses but not for non–RA‐associated anti–tetanus toxoid antibodies. As expected, we found a high correlation between citrullinated vimentin and MCV responses. All synovial fluid ACPAs were predominantly associated with HLA–DRB1*04 alleles and were confined to the CCP+/MCV+ subset of patients.
Conclusion
MCV and CCP positivity represent a similar subset of RA patients, whereas ACPAs with different fine specificities fall into subgroups of anti‐CCP+/anti‐MCV+ patients. The levels of all specific ACPAs were elevated in synovial fluid, suggesting that there is local antibody production and/or retention of ACPAs at the site of inflammation governed by RA‐predisposing genes.</description><identifier>ISSN: 0004-3591</identifier><identifier>ISSN: 1529-0131</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.25036</identifier><identifier>PMID: 20039432</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Autoantibodies - blood ; Autoantigens - immunology ; Biological and medical sciences ; Biomarkers, Tumor - immunology ; Citrulline - chemistry ; Citrulline - immunology ; Collagen Type II - immunology ; Diseases of the osteoarticular system ; DNA-Binding Proteins - immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Fibrinogen - chemistry ; Fibrinogen - immunology ; Genotype ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Mutation ; Peptides, Cyclic - immunology ; Phosphopyruvate Hydratase - immunology ; Synovial Fluid - immunology ; Tumor Suppressor Proteins - immunology ; Vimentin - chemistry ; Vimentin - genetics ; Vimentin - immunology ; Young Adult</subject><ispartof>Arthritis and rheumatism, 2010-01, Vol.62 (1), p.44-52</ispartof><rights>Copyright © 2010 by the American College of Rheumatology</rights><rights>2015 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6146-88c438305a31e715b82eb6713e7ce27c4626a6644d9451fd28e07fc8d03266e13</citedby><cites>FETCH-LOGICAL-c6146-88c438305a31e715b82eb6713e7ce27c4626a6644d9451fd28e07fc8d03266e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.25036$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.25036$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22337945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20039432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-27250$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140009$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120918725$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Snir, Omri</creatorcontrib><creatorcontrib>Widhe, Mona</creatorcontrib><creatorcontrib>Hermansson, Monika</creatorcontrib><creatorcontrib>von Spee, Caroline</creatorcontrib><creatorcontrib>Lindberg, Johan</creatorcontrib><creatorcontrib>Hensen, Sanne</creatorcontrib><creatorcontrib>Lundberg, Karin</creatorcontrib><creatorcontrib>Engström, Åke</creatorcontrib><creatorcontrib>Venables, Patrick J. W.</creatorcontrib><creatorcontrib>Toes, René E. M.</creatorcontrib><creatorcontrib>Holmdahl, Rikard</creatorcontrib><creatorcontrib>Klareskog, Lars</creatorcontrib><creatorcontrib>Malmström, Vivianne</creatorcontrib><title>Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective
High titers of specific anti–citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well‐defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA‐specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well‐defined HLA–DR groups.
Methods
Paired serum and synovial fluid samples from 290 RA patients and serum samples from 100 age‐ and sex‐matched healthy controls were analyzed for the presence of anti‐MCV and anti‐CCP antibodies and for reactivity to citrullinated fibrinogen, α‐enolase, type II collagen, and vimentin. A total of 219 of the 290 patients were genotyped for the HLA–DR shared epitope alleles.
Results
Significantly higher proportions of antibodies against all RA‐associated citrullinated antigens were found in synovial fluid as compared with serum. This was also true for the MCV and CCP responses but not for non–RA‐associated anti–tetanus toxoid antibodies. As expected, we found a high correlation between citrullinated vimentin and MCV responses. All synovial fluid ACPAs were predominantly associated with HLA–DRB1*04 alleles and were confined to the CCP+/MCV+ subset of patients.
Conclusion
MCV and CCP positivity represent a similar subset of RA patients, whereas ACPAs with different fine specificities fall into subgroups of anti‐CCP+/anti‐MCV+ patients. The levels of all specific ACPAs were elevated in synovial fluid, suggesting that there is local antibody production and/or retention of ACPAs at the site of inflammation governed by RA‐predisposing genes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoantibodies - blood</subject><subject>Autoantigens - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - immunology</subject><subject>Citrulline - chemistry</subject><subject>Citrulline - immunology</subject><subject>Collagen Type II - immunology</subject><subject>Diseases of the osteoarticular system</subject><subject>DNA-Binding Proteins - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fibrinogen - chemistry</subject><subject>Fibrinogen - immunology</subject><subject>Genotype</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Peptides, Cyclic - immunology</subject><subject>Phosphopyruvate Hydratase - immunology</subject><subject>Synovial Fluid - immunology</subject><subject>Tumor Suppressor Proteins - immunology</subject><subject>Vimentin - chemistry</subject><subject>Vimentin - genetics</subject><subject>Vimentin - immunology</subject><subject>Young Adult</subject><issn>0004-3591</issn><issn>1529-0131</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ltrFDEUB_Agil1XH_wCkhcpgtPmPpPHpdYLFASpvoZs5kwn7exkTTKWfvtmnW37tOhTLvz-Scg5CL2l5IQSwk5tzCdMEq6eoQWVTFeEcvocLQghouJS0yP0KqXrsmRc8pfoiBHCteBsgfrVmP06tB4SzgEn-APRDtj5HKdh8KPN0GJbzBWMCdsIGMboXV92_YhzD_g6-DEnHDoce5g2NgdfEjH30Wef8NZmDwW8Ri86OyR4sx-X6Ofn88uzr9XF9y_fzlYXlVNUqKppnOANJ9JyCjWV64bBWtWUQ-2A1U4opqxSQrRaSNq1rAFSd65pCWdKAeVLVM3nplvYTmuzjX5j450J1pv91k2ZgZFy9wXF64N-G0P7FHoIUkY0bWomS_bjwewn_2tlQrwy02SoKF-v_4_f5N6welfNJTqeeXnG7wlSNhufHAyDHSFMydRC6iJr9m_JudJCq6bID7N0MaQUoXt8BCVm10umVM787aVi3-1PndYbaB_lQ_MU8H4PbHJ26KIdnU9PjnFelyoVdzq7Wz_A3eEbzerH5Xz1PRn94cw</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Snir, Omri</creator><creator>Widhe, Mona</creator><creator>Hermansson, Monika</creator><creator>von Spee, Caroline</creator><creator>Lindberg, Johan</creator><creator>Hensen, Sanne</creator><creator>Lundberg, Karin</creator><creator>Engström, Åke</creator><creator>Venables, Patrick J. W.</creator><creator>Toes, René E. M.</creator><creator>Holmdahl, Rikard</creator><creator>Klareskog, Lars</creator><creator>Malmström, Vivianne</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8V</scope><scope>DF2</scope></search><sort><creationdate>201001</creationdate><title>Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients</title><author>Snir, Omri ; Widhe, Mona ; Hermansson, Monika ; von Spee, Caroline ; Lindberg, Johan ; Hensen, Sanne ; Lundberg, Karin ; Engström, Åke ; Venables, Patrick J. W. ; Toes, René E. M. ; Holmdahl, Rikard ; Klareskog, Lars ; Malmström, Vivianne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6146-88c438305a31e715b82eb6713e7ce27c4626a6644d9451fd28e07fc8d03266e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoantibodies - blood</topic><topic>Autoantigens - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - immunology</topic><topic>Citrulline - chemistry</topic><topic>Citrulline - immunology</topic><topic>Collagen Type II - immunology</topic><topic>Diseases of the osteoarticular system</topic><topic>DNA-Binding Proteins - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fibrinogen - chemistry</topic><topic>Fibrinogen - immunology</topic><topic>Genotype</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Peptides, Cyclic - immunology</topic><topic>Phosphopyruvate Hydratase - immunology</topic><topic>Synovial Fluid - immunology</topic><topic>Tumor Suppressor Proteins - immunology</topic><topic>Vimentin - chemistry</topic><topic>Vimentin - genetics</topic><topic>Vimentin - immunology</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Snir, Omri</creatorcontrib><creatorcontrib>Widhe, Mona</creatorcontrib><creatorcontrib>Hermansson, Monika</creatorcontrib><creatorcontrib>von Spee, Caroline</creatorcontrib><creatorcontrib>Lindberg, Johan</creatorcontrib><creatorcontrib>Hensen, Sanne</creatorcontrib><creatorcontrib>Lundberg, Karin</creatorcontrib><creatorcontrib>Engström, Åke</creatorcontrib><creatorcontrib>Venables, Patrick J. W.</creatorcontrib><creatorcontrib>Toes, René E. M.</creatorcontrib><creatorcontrib>Holmdahl, Rikard</creatorcontrib><creatorcontrib>Klareskog, Lars</creatorcontrib><creatorcontrib>Malmström, Vivianne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Kungliga Tekniska Högskolan</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snir, Omri</au><au>Widhe, Mona</au><au>Hermansson, Monika</au><au>von Spee, Caroline</au><au>Lindberg, Johan</au><au>Hensen, Sanne</au><au>Lundberg, Karin</au><au>Engström, Åke</au><au>Venables, Patrick J. W.</au><au>Toes, René E. M.</au><au>Holmdahl, Rikard</au><au>Klareskog, Lars</au><au>Malmström, Vivianne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>2010-01</date><risdate>2010</risdate><volume>62</volume><issue>1</issue><spage>44</spage><epage>52</epage><pages>44-52</pages><issn>0004-3591</issn><issn>1529-0131</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>Objective
High titers of specific anti–citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well‐defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA‐specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well‐defined HLA–DR groups.
Methods
Paired serum and synovial fluid samples from 290 RA patients and serum samples from 100 age‐ and sex‐matched healthy controls were analyzed for the presence of anti‐MCV and anti‐CCP antibodies and for reactivity to citrullinated fibrinogen, α‐enolase, type II collagen, and vimentin. A total of 219 of the 290 patients were genotyped for the HLA–DR shared epitope alleles.
Results
Significantly higher proportions of antibodies against all RA‐associated citrullinated antigens were found in synovial fluid as compared with serum. This was also true for the MCV and CCP responses but not for non–RA‐associated anti–tetanus toxoid antibodies. As expected, we found a high correlation between citrullinated vimentin and MCV responses. All synovial fluid ACPAs were predominantly associated with HLA–DRB1*04 alleles and were confined to the CCP+/MCV+ subset of patients.
Conclusion
MCV and CCP positivity represent a similar subset of RA patients, whereas ACPAs with different fine specificities fall into subgroups of anti‐CCP+/anti‐MCV+ patients. The levels of all specific ACPAs were elevated in synovial fluid, suggesting that there is local antibody production and/or retention of ACPAs at the site of inflammation governed by RA‐predisposing genes.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20039432</pmid><doi>10.1002/art.25036</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - blood Autoantigens - immunology Biological and medical sciences Biomarkers, Tumor - immunology Citrulline - chemistry Citrulline - immunology Collagen Type II - immunology Diseases of the osteoarticular system DNA-Binding Proteins - immunology Enzyme-Linked Immunosorbent Assay Female Fibrinogen - chemistry Fibrinogen - immunology Genotype HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Inflammatory joint diseases Male Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Middle Aged Mutation Peptides, Cyclic - immunology Phosphopyruvate Hydratase - immunology Synovial Fluid - immunology Tumor Suppressor Proteins - immunology Vimentin - chemistry Vimentin - genetics Vimentin - immunology Young Adult |
| title | Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients |
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