Intergenerational Cardiovascular Disease Risk Factors Involve Both Maternal and Paternal BMI
OBJECTIVE: To examine the association between parental BMI and offspring cardiovascular disease (CVD) risk factors. RESEARCH DESIGN AND METHODS: The study comprised 940 children (9.5 ± 0.4 years) and 873 adolescents (15.5 ± 0.5 years). Parental weight and height were reported by the mother and the f...
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| Veröffentlicht in: | Diabetes care 2010-04, Vol.33 (4), p.894-900 |
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| creator | Labayen, Idoia Ruiz, Jonatan R Ortega, Francisco B Loit, Helle-Mai Harro, Jaanus Veidebaum, Toomas Sjöström, Michael |
| description | OBJECTIVE: To examine the association between parental BMI and offspring cardiovascular disease (CVD) risk factors. RESEARCH DESIGN AND METHODS: The study comprised 940 children (9.5 ± 0.4 years) and 873 adolescents (15.5 ± 0.5 years). Parental weight and height were reported by the mother and the father, and BMI was calculated. CVD risk factors included total (sum of five skinfolds) and central (waist circumference) body fat, blood pressure, cardiorespiratory fitness, insulin sensitivity, total cholesterol, HDL cholesterol, triglycerides, and fibrinogen. RESULTS: Maternal and paternal BMI were positively associated with total and central fatness in offspring (P < 0.001). BMIs of both parents were significantly related to fibrinogen levels (P < 0.02), but these associations disappeared when controlling for fatness. There was a positive relationship between maternal and paternal BMI and waist circumference in the offspring regardless of total adiposity and height (P < 0.001). Maternal BMI was negatively associated with offspring cardiorespiratory fitness independently of fatness (P < 0.02). These relationships persisted when overweight descendants were excluded from the analysis. There were no significant associations between parental BMI and the other CVD risk factors. CONCLUSIONS: Both maternal and paternal BMI increase CVD risk factors of their offspring, characterized by total and central body fat, and higher maternal BMI was associated with poorer cardiorespiratory fitness. Our findings give further support to the concept that adiposity in parents transmits susceptibility to CVD risk to descendants, which is detectable even in the absence of overweight in offspring. |
| doi_str_mv | 10.2337/dc09-1878 |
| format | Article |
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RESEARCH DESIGN AND METHODS: The study comprised 940 children (9.5 ± 0.4 years) and 873 adolescents (15.5 ± 0.5 years). Parental weight and height were reported by the mother and the father, and BMI was calculated. CVD risk factors included total (sum of five skinfolds) and central (waist circumference) body fat, blood pressure, cardiorespiratory fitness, insulin sensitivity, total cholesterol, HDL cholesterol, triglycerides, and fibrinogen. RESULTS: Maternal and paternal BMI were positively associated with total and central fatness in offspring (P < 0.001). BMIs of both parents were significantly related to fibrinogen levels (P < 0.02), but these associations disappeared when controlling for fatness. There was a positive relationship between maternal and paternal BMI and waist circumference in the offspring regardless of total adiposity and height (P < 0.001). Maternal BMI was negatively associated with offspring cardiorespiratory fitness independently of fatness (P < 0.02). These relationships persisted when overweight descendants were excluded from the analysis. There were no significant associations between parental BMI and the other CVD risk factors. CONCLUSIONS: Both maternal and paternal BMI increase CVD risk factors of their offspring, characterized by total and central body fat, and higher maternal BMI was associated with poorer cardiorespiratory fitness. Our findings give further support to the concept that adiposity in parents transmits susceptibility to CVD risk to descendants, which is detectable even in the absence of overweight in offspring.</description><identifier>ISSN: 0149-5992</identifier><identifier>ISSN: 1935-5548</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc09-1878</identifier><identifier>PMID: 20056951</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adolescent ; Behavior ; Biological and medical sciences ; Blood cholesterol ; Blood pressure ; Body Mass Index ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Child ; Councils ; Data collection ; Diabetes. Impaired glucose tolerance ; Diet ; Education ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Fathers ; Female ; Fibrin ; Fibrinogen ; Humans ; Male ; Medical research ; Medical sciences ; Medicin och hälsovetenskap ; Medicine, Experimental ; Metabolic diseases ; Miscellaneous ; Mothers ; Obesity ; Original Research ; Parenting ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Studies ; Triglycerides</subject><ispartof>Diabetes care, 2010-04, Vol.33 (4), p.894-900</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 American Diabetes Association</rights><rights>Copyright American Diabetes Association Apr 2010</rights><rights>2010 by the American Diabetes Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c647t-e3c7d9e974ffbca546e1d2535b70ced358a1b5bda04794631aaeb7c9533d94833</citedby><cites>FETCH-LOGICAL-c647t-e3c7d9e974ffbca546e1d2535b70ced358a1b5bda04794631aaeb7c9533d94833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,553,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22630133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20056951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120299708$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Labayen, Idoia</creatorcontrib><creatorcontrib>Ruiz, Jonatan R</creatorcontrib><creatorcontrib>Ortega, Francisco B</creatorcontrib><creatorcontrib>Loit, Helle-Mai</creatorcontrib><creatorcontrib>Harro, Jaanus</creatorcontrib><creatorcontrib>Veidebaum, Toomas</creatorcontrib><creatorcontrib>Sjöström, Michael</creatorcontrib><title>Intergenerational Cardiovascular Disease Risk Factors Involve Both Maternal and Paternal BMI</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE: To examine the association between parental BMI and offspring cardiovascular disease (CVD) risk factors. RESEARCH DESIGN AND METHODS: The study comprised 940 children (9.5 ± 0.4 years) and 873 adolescents (15.5 ± 0.5 years). Parental weight and height were reported by the mother and the father, and BMI was calculated. CVD risk factors included total (sum of five skinfolds) and central (waist circumference) body fat, blood pressure, cardiorespiratory fitness, insulin sensitivity, total cholesterol, HDL cholesterol, triglycerides, and fibrinogen. RESULTS: Maternal and paternal BMI were positively associated with total and central fatness in offspring (P < 0.001). BMIs of both parents were significantly related to fibrinogen levels (P < 0.02), but these associations disappeared when controlling for fatness. There was a positive relationship between maternal and paternal BMI and waist circumference in the offspring regardless of total adiposity and height (P < 0.001). Maternal BMI was negatively associated with offspring cardiorespiratory fitness independently of fatness (P < 0.02). These relationships persisted when overweight descendants were excluded from the analysis. There were no significant associations between parental BMI and the other CVD risk factors. CONCLUSIONS: Both maternal and paternal BMI increase CVD risk factors of their offspring, characterized by total and central body fat, and higher maternal BMI was associated with poorer cardiorespiratory fitness. Our findings give further support to the concept that adiposity in parents transmits susceptibility to CVD risk to descendants, which is detectable even in the absence of overweight in offspring.</description><subject>Adolescent</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Blood cholesterol</subject><subject>Blood pressure</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Child</subject><subject>Councils</subject><subject>Data collection</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet</subject><subject>Education</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Fathers</subject><subject>Female</subject><subject>Fibrin</subject><subject>Fibrinogen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine, Experimental</subject><subject>Metabolic diseases</subject><subject>Miscellaneous</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Original Research</subject><subject>Parenting</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Triglycerides</subject><issn>0149-5992</issn><issn>1935-5548</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>D8T</sourceid><recordid>eNp1kl1v0zAYhSMEYmVwwR-ATAghLjL82dg3SFthUGkTCNgdkvXWedN5S-Nip0X8exzSrhQN-SL-eM6xfHKy7Cklx4zz8k1liS6oKtW9bEQ1l4WUQt3PRoQKXUit2UH2KMZrQogQSj3MDhghcqwlHWXfp22HYY4tBuicb6HJJxAq59cQ7aqBkL9zESFi_sXFm_wMbOdDzKft2jdrzE99d5VfQLLoldBW-eft4vRi-jh7UEMT8cnme5hdnr3_NvlYnH_6MJ2cnBd2LMquQG7LSqMuRV3PLEgxRloxyeWsJBYrLhXQmZxVQESpxZhTAJyVVkvOKy0U54dZMfjGn7hczcwyuAWEX8aDM5utmzRDIyVXTCde_5dfBl_tRFshZYRpXRKVtG8HbQIWWFlsuwDNvsXeSeuuzNyvDVNCEtEbvNoYBP9jhbEzCxctNg206FfRlJwLwgTvn3X0D3ntV3220ShNS0YETcyLgZlDg8a1tU-X2t7RnDAmBEkhyV1Ae9Tw1xvfYu3S9h5_fAefRoULZ-8UvB4ENvgYA9a3gVBi-o6avqOm72hin_2d4C25LWUCXm6A1EFo6gCtdXHHsTEn9E8-zweuBm9gHhJz-ZWlI0IVY1Ip_hvUyPeq</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Labayen, Idoia</creator><creator>Ruiz, Jonatan R</creator><creator>Ortega, Francisco B</creator><creator>Loit, Helle-Mai</creator><creator>Harro, Jaanus</creator><creator>Veidebaum, Toomas</creator><creator>Sjöström, Michael</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20100401</creationdate><title>Intergenerational Cardiovascular Disease Risk Factors Involve Both Maternal and Paternal BMI</title><author>Labayen, Idoia ; Ruiz, Jonatan R ; Ortega, Francisco B ; Loit, Helle-Mai ; Harro, Jaanus ; Veidebaum, Toomas ; Sjöström, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c647t-e3c7d9e974ffbca546e1d2535b70ced358a1b5bda04794631aaeb7c9533d94833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Blood cholesterol</topic><topic>Blood pressure</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Child</topic><topic>Councils</topic><topic>Data collection</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet</topic><topic>Education</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Fathers</topic><topic>Female</topic><topic>Fibrin</topic><topic>Fibrinogen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicine, Experimental</topic><topic>Metabolic diseases</topic><topic>Miscellaneous</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Original Research</topic><topic>Parenting</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Labayen, Idoia</creatorcontrib><creatorcontrib>Ruiz, Jonatan R</creatorcontrib><creatorcontrib>Ortega, Francisco B</creatorcontrib><creatorcontrib>Loit, Helle-Mai</creatorcontrib><creatorcontrib>Harro, Jaanus</creatorcontrib><creatorcontrib>Veidebaum, Toomas</creatorcontrib><creatorcontrib>Sjöström, Michael</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Labayen, Idoia</au><au>Ruiz, Jonatan R</au><au>Ortega, Francisco B</au><au>Loit, Helle-Mai</au><au>Harro, Jaanus</au><au>Veidebaum, Toomas</au><au>Sjöström, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intergenerational Cardiovascular Disease Risk Factors Involve Both Maternal and Paternal BMI</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>33</volume><issue>4</issue><spage>894</spage><epage>900</epage><pages>894-900</pages><issn>0149-5992</issn><issn>1935-5548</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE: To examine the association between parental BMI and offspring cardiovascular disease (CVD) risk factors. RESEARCH DESIGN AND METHODS: The study comprised 940 children (9.5 ± 0.4 years) and 873 adolescents (15.5 ± 0.5 years). Parental weight and height were reported by the mother and the father, and BMI was calculated. CVD risk factors included total (sum of five skinfolds) and central (waist circumference) body fat, blood pressure, cardiorespiratory fitness, insulin sensitivity, total cholesterol, HDL cholesterol, triglycerides, and fibrinogen. RESULTS: Maternal and paternal BMI were positively associated with total and central fatness in offspring (P < 0.001). BMIs of both parents were significantly related to fibrinogen levels (P < 0.02), but these associations disappeared when controlling for fatness. There was a positive relationship between maternal and paternal BMI and waist circumference in the offspring regardless of total adiposity and height (P < 0.001). Maternal BMI was negatively associated with offspring cardiorespiratory fitness independently of fatness (P < 0.02). These relationships persisted when overweight descendants were excluded from the analysis. There were no significant associations between parental BMI and the other CVD risk factors. CONCLUSIONS: Both maternal and paternal BMI increase CVD risk factors of their offspring, characterized by total and central body fat, and higher maternal BMI was associated with poorer cardiorespiratory fitness. Our findings give further support to the concept that adiposity in parents transmits susceptibility to CVD risk to descendants, which is detectable even in the absence of overweight in offspring.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>20056951</pmid><doi>10.2337/dc09-1878</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SWEPUB Freely available online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Behavior Biological and medical sciences Blood cholesterol Blood pressure Body Mass Index Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Child Councils Data collection Diabetes. Impaired glucose tolerance Diet Education Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fathers Female Fibrin Fibrinogen Humans Male Medical research Medical sciences Medicin och hälsovetenskap Medicine, Experimental Metabolic diseases Miscellaneous Mothers Obesity Original Research Parenting Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Studies Triglycerides |
| title | Intergenerational Cardiovascular Disease Risk Factors Involve Both Maternal and Paternal BMI |
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