Hedgehog beyond medulloblastoma and basal cell carcinoma

The Hedgehog (Hh) signaling pathway is of central importance during embryo development in metazoans and governs a diverse array of processes including cell proliferation, differentiation, and tissue patterning. In normal adult physiology, the pathway is implicated in stem cell maintenance, tissue re...

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Veröffentlicht in:	Biochimica et biophysica acta 2010-04, Vol.1805 (2), p.181-208
Hauptverfasser:	Teglund, Stephan, Toftgård, Rune
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Basal cell carcinoma Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - metabolism Hedgehog pathway Hedgehog Proteins - metabolism Humans Medicin och hälsovetenskap Medulloblastoma Medulloblastoma - drug therapy Medulloblastoma - metabolism Mouse cancer models Pancreatic cancer Signal Transduction - physiology Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Small-molecule inhibitors
Online-Zugang:	Volltext
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