Enhanced expression of the neuronal K+ /Cl− cotransporter, KCC2, in spontaneously depressed Flinders Sensitive Line rats

Abstract We used Flinder Sensitive Line (FSL) rats, a genetic model of unipolar depression, to examine whether changes in central GABAergic transmission are associated with a depressed phenotype. FSL rats showed an increased behavioral response to low doses of diazepam, as compared to either Sprague...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2010-04, Vol.1325, p.112-120
Hauptverfasser:	Matrisciano, F, Nasca, C, Molinaro, G, Riozzi, B, Scaccianoce, S, Raggi, M.A, Mercolini, L, Biagioni, F, Mathè, A.A, Sanna, E, Maciocco, E, Pignatelli, M, Biggio, G, Nicoletti, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Benzodiazepine Biological and medical sciences Central Nervous System Agents - administration & dosage Central Nervous System Agents - pharmacokinetics Central Nervous System Agents - pharmacology Cerebellum - drug effects Cerebellum - metabolism Cerebral Cortex - drug effects Cerebral Cortex - metabolism Depression Depressive Disorder - metabolism Diazepam - administration & dosage Diazepam - pharmacokinetics Diazepam - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Flinder Sensitive Line rat Hippocampus - drug effects Hippocampus - metabolism K Cl- Cotransporters KCC2 Male Medical sciences Mood disorders Motor Skills - drug effects Neurology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Receptors, GABA-A - metabolism Species Specificity Symporters - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!