Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk

We conducted dense linkage disequilibrium (LD) mapping of a series of 25 genes putatively involved in lipid metabolism in 1567 dementia cases [including 1270 with Alzheimer disease (AD)] and 2203 Swedish controls. Across a total of 448 tested genetic markers, the strongest evidence of association wa...

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Veröffentlicht in:	Human molecular genetics 2010-05, Vol.19 (10), p.2068-2078
Hauptverfasser:	Reynolds, Chandra A., Hong, Mun-Gwan, Eriksson, Ulrika K., Blennow, Kaj, Wiklund, Fredrik, Johansson, Boo, Malmberg, Bo, Berg, Stig, Alexeyenko, Andrey, Grönberg, Henrik, Gatz, Margaret, Pedersen, Nancy L., Prince, Jonathan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - genetics Association Studies Carrier Proteins - genetics Chaperonins - genetics Dementia - genetics Female Gene Regulatory Networks - genetics Genetic Markers Genetic Predisposition to Disease Humans Linkage Disequilibrium - genetics Lipid Metabolism - genetics Male Medicin och hälsovetenskap Mutation - genetics Polymorphism, Single Nucleotide - genetics Proton-Translocating ATPases - genetics Psychiatry Psykiatri Sterol Regulatory Element Binding Protein 1 - genetics
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