The ubiquitin C‐terminal hydrolase UCH‐L1 regulates B‐cell proliferation and integrin activation

The ubiquitin C‐terminal hydrolase‐L1 (UCH‐L1) is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts. UCH‐L1 has been detected in a variety of malignant and metastatic tumours but its biological function in these cells is unknown. We have...

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Veröffentlicht in:	JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2009-08, Vol.13 (8b), p.1666-1678
Hauptverfasser:	Rolén, Ulrika, Freda, Elio, Xie, Jianjun, Pfirrmann, Thorsten, Frisan, Teresa, Masucci, Maria G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Antibodies B-Lymphocytes - cytology Base Sequence Biochemistry Burkitt's lymphoma Cancer Catalysis Cell activation Cell adhesion Cell growth Cell Line, Tumor Cell Proliferation Cells Cloning DNA Primers Enzymatic activity Enzymes Epstein-Barr virus Humans Hydrolase integrin activation Integrins - metabolism Intercellular adhesion molecule 1 Invasiveness Laboratories LFA-1 antigen Lipid rafts Lymphocytes Lymphocytes B Lymphoma Metastases Phenotypes Plasmids Protein gene product 9.5 Proteins Rac1 protein Rap1 protein RNA-mediated interference Signal transduction tumor progression Tumors Ubiquitin Ubiquitin carboxy-terminal hydrolase Ubiquitin Thiolesterase - physiology UCH‐L1 Up-Regulation
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