No effect of obstetric complications on basal ganglia volumes in schizophrenia
Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. A...
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description | Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. Altered volumes of other brain structures (e.g. hippocampus and lateral ventricles) have been reported in schizophrenia patients with a history of obstetric complications (OCs). This is the first study to explore if there is a relationship between OCs and basal ganglia volume in schizophrenia.
Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was undertaken. MR images were obtained on a 1.5
T scanner, and volumes of nucleus caudatus, globus pallidum, putamen, and nucleus accumbens were quantified automatically. Information on OCs was blindly collected from original birth records.
Unadjusted estimates demonstrated a relationship between increasing number of OCs and larger volume of nucleus accumbens in schizophrenia patients and healthy controls. No statistically significant relationships were found between OCs and the basal ganglia volumes when controlled for intracranial volume, age, and multiple comparisons. There were no effects of typical versus atypical medication on the basal ganglia volumes. The patients with schizophrenia had larger globus pallidum volumes as compared to healthy controls, but there were no case–control differences for accumbens, putamen, or caudate volumes.
The present results do not support the hypothesis that OCs are related to alterations in basal ganglia volume in chronic schizophrenia. |
doi_str_mv | 10.1016/j.pnpbp.2010.02.024 |
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Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was undertaken. MR images were obtained on a 1.5
T scanner, and volumes of nucleus caudatus, globus pallidum, putamen, and nucleus accumbens were quantified automatically. Information on OCs was blindly collected from original birth records.
Unadjusted estimates demonstrated a relationship between increasing number of OCs and larger volume of nucleus accumbens in schizophrenia patients and healthy controls. No statistically significant relationships were found between OCs and the basal ganglia volumes when controlled for intracranial volume, age, and multiple comparisons. There were no effects of typical versus atypical medication on the basal ganglia volumes. The patients with schizophrenia had larger globus pallidum volumes as compared to healthy controls, but there were no case–control differences for accumbens, putamen, or caudate volumes.
The present results do not support the hypothesis that OCs are related to alterations in basal ganglia volume in chronic schizophrenia.</description><identifier>ISSN: 0278-5846</identifier><identifier>ISSN: 1878-4216</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2010.02.024</identifier><identifier>PMID: 20193725</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Arbetsmedicin och miljömedicin ; Basal ganglia ; Basal Ganglia - pathology ; Biological and medical sciences ; complications ; Dopamine ; Environmental Health and Occupational Health ; Female ; Health Sciences ; Humans ; Hälsovetenskap ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; MRI ; Neurodevelopment ; Neuropharmacology ; Obstetric ; Obstetric complications ; Obstetric Labor Complications ; Organ Size ; Patient Selection ; Pharmacology. Drug treatments ; Pregnancy ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Regression Analysis ; Schizophrenia ; Schizophrenia - pathology ; Statistics, Nonparametric</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2010-05, Vol.34 (4), p.619-623</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-f8b55195f1dd306fe8ea6d92d4ae35b04f6d6d419398c84313a97919fb84acc23</citedby><cites>FETCH-LOGICAL-c622t-f8b55195f1dd306fe8ea6d92d4ae35b04f6d6d419398c84313a97919fb84acc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2010.02.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,552,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22842644$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20193725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1630275$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120870539$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Haukvik, Unn Kristin</creatorcontrib><creatorcontrib>McNeil, Thomas</creatorcontrib><creatorcontrib>Nesvåg, Ragnar</creatorcontrib><creatorcontrib>Söderman, Erik</creatorcontrib><creatorcontrib>Jönsson, Erik</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><title>No effect of obstetric complications on basal ganglia volumes in schizophrenia</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. Altered volumes of other brain structures (e.g. hippocampus and lateral ventricles) have been reported in schizophrenia patients with a history of obstetric complications (OCs). This is the first study to explore if there is a relationship between OCs and basal ganglia volume in schizophrenia.
Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was undertaken. MR images were obtained on a 1.5
T scanner, and volumes of nucleus caudatus, globus pallidum, putamen, and nucleus accumbens were quantified automatically. Information on OCs was blindly collected from original birth records.
Unadjusted estimates demonstrated a relationship between increasing number of OCs and larger volume of nucleus accumbens in schizophrenia patients and healthy controls. No statistically significant relationships were found between OCs and the basal ganglia volumes when controlled for intracranial volume, age, and multiple comparisons. There were no effects of typical versus atypical medication on the basal ganglia volumes. The patients with schizophrenia had larger globus pallidum volumes as compared to healthy controls, but there were no case–control differences for accumbens, putamen, or caudate volumes.
The present results do not support the hypothesis that OCs are related to alterations in basal ganglia volume in chronic schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Arbetsmedicin och miljömedicin</subject><subject>Basal ganglia</subject><subject>Basal Ganglia - pathology</subject><subject>Biological and medical sciences</subject><subject>complications</subject><subject>Dopamine</subject><subject>Environmental Health and Occupational Health</subject><subject>Female</subject><subject>Health Sciences</subject><subject>Humans</subject><subject>Hälsovetenskap</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Neurodevelopment</subject><subject>Neuropharmacology</subject><subject>Obstetric</subject><subject>Obstetric complications</subject><subject>Obstetric Labor Complications</subject><subject>Organ Size</subject><subject>Patient Selection</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Regression Analysis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Statistics, Nonparametric</subject><issn>0278-5846</issn><issn>1878-4216</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFkktv1DAUhSMEokPhFyChbFBXGfyOs2CBKl7SqGxgbflx3XpI4mAnreivx2Gm7aog-cpX1neuj3RPVb3GaIsRFu_222mczLQlqLwgUg57Um2wbGXDCBZPqw0ipeeSiZPqRc57hBCmiD6vToqkoy3hm-riItbgPdi5jr6OJs8wp2BrG4epD1bPIY65jmNtdNZ9fanHyz7o-jr2ywC5DmOd7VW4jdNVgjHol9Uzr_sMr473afXj08fv51-a3bfPX88_7BorCJkbLw3nuOMeO0eR8CBBC9cRxzRQbhDzwgnHislOWskoprprO9x5I5m2ltDTqjnMzTcwLUZNKQw6_VZRB3V8-lk6UJwTKdvCd4_yU4ruQXQnxATJFnHaFe3uUW2_TKVMqVXTFmtECqwAGaGYNaCksFQRzTVFoCl2q_Wzw7jy768F8qyGkC30vR4hLlm1jAkiOJP_JymlZd1EFJIeSJtizgn8vUmM1BoWtVd_w6LWsChEymFF9eY4fzEDuHvNXToK8PYI6Gx175MebcgPHJGMCLYOen_goKz8OkBS2QYYLbiQSrKUi-GfRv4AXmbfSw</recordid><startdate>20100530</startdate><enddate>20100530</enddate><creator>Haukvik, Unn Kristin</creator><creator>McNeil, Thomas</creator><creator>Nesvåg, Ragnar</creator><creator>Söderman, Erik</creator><creator>Jönsson, Erik</creator><creator>Agartz, Ingrid</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D95</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20100530</creationdate><title>No effect of obstetric complications on basal ganglia volumes in schizophrenia</title><author>Haukvik, Unn Kristin ; McNeil, Thomas ; Nesvåg, Ragnar ; Söderman, Erik ; Jönsson, Erik ; Agartz, Ingrid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-f8b55195f1dd306fe8ea6d92d4ae35b04f6d6d419398c84313a97919fb84acc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Arbetsmedicin och miljömedicin</topic><topic>Basal ganglia</topic><topic>Basal Ganglia - pathology</topic><topic>Biological and medical sciences</topic><topic>complications</topic><topic>Dopamine</topic><topic>Environmental Health and Occupational Health</topic><topic>Female</topic><topic>Health Sciences</topic><topic>Humans</topic><topic>Hälsovetenskap</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Neurodevelopment</topic><topic>Neuropharmacology</topic><topic>Obstetric</topic><topic>Obstetric complications</topic><topic>Obstetric Labor Complications</topic><topic>Organ Size</topic><topic>Patient Selection</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Regression Analysis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haukvik, Unn Kristin</creatorcontrib><creatorcontrib>McNeil, Thomas</creatorcontrib><creatorcontrib>Nesvåg, Ragnar</creatorcontrib><creatorcontrib>Söderman, Erik</creatorcontrib><creatorcontrib>Jönsson, Erik</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Lunds universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haukvik, Unn Kristin</au><au>McNeil, Thomas</au><au>Nesvåg, Ragnar</au><au>Söderman, Erik</au><au>Jönsson, Erik</au><au>Agartz, Ingrid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No effect of obstetric complications on basal ganglia volumes in schizophrenia</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2010-05-30</date><risdate>2010</risdate><volume>34</volume><issue>4</issue><spage>619</spage><epage>623</epage><pages>619-623</pages><issn>0278-5846</issn><issn>1878-4216</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. Altered volumes of other brain structures (e.g. hippocampus and lateral ventricles) have been reported in schizophrenia patients with a history of obstetric complications (OCs). This is the first study to explore if there is a relationship between OCs and basal ganglia volume in schizophrenia.
Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was undertaken. MR images were obtained on a 1.5
T scanner, and volumes of nucleus caudatus, globus pallidum, putamen, and nucleus accumbens were quantified automatically. Information on OCs was blindly collected from original birth records.
Unadjusted estimates demonstrated a relationship between increasing number of OCs and larger volume of nucleus accumbens in schizophrenia patients and healthy controls. No statistically significant relationships were found between OCs and the basal ganglia volumes when controlled for intracranial volume, age, and multiple comparisons. There were no effects of typical versus atypical medication on the basal ganglia volumes. The patients with schizophrenia had larger globus pallidum volumes as compared to healthy controls, but there were no case–control differences for accumbens, putamen, or caudate volumes.
The present results do not support the hypothesis that OCs are related to alterations in basal ganglia volume in chronic schizophrenia.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20193725</pmid><doi>10.1016/j.pnpbp.2010.02.024</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Adult and adolescent clinical studies Arbetsmedicin och miljömedicin Basal ganglia Basal Ganglia - pathology Biological and medical sciences complications Dopamine Environmental Health and Occupational Health Female Health Sciences Humans Hälsovetenskap Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Middle Aged MRI Neurodevelopment Neuropharmacology Obstetric Obstetric complications Obstetric Labor Complications Organ Size Patient Selection Pharmacology. Drug treatments Pregnancy Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Regression Analysis Schizophrenia Schizophrenia - pathology Statistics, Nonparametric |
title | No effect of obstetric complications on basal ganglia volumes in schizophrenia |
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