Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?
Omega-3 fatty acids have been implicated in cancer prevention and treatment. Conventional chemotherapeutics are considered “double-edged swords”, as they kill the cancer cells but also strike the healthy cells causing severe morbidity and sometimes also mortality. Could omega-3 fatty acids in this s...
Gespeichert in:
| Veröffentlicht in: | Experimental cell research 2010-05, Vol.316 (8), p.1365-1373 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1373 |
|---|---|
| container_issue | 8 |
| container_start_page | 1365 |
| container_title | Experimental cell research |
| container_volume | 316 |
| creator | Gleissman, Helena Johnsen, John Inge Kogner, Per |
| description | Omega-3 fatty acids have been implicated in cancer prevention and treatment. Conventional chemotherapeutics are considered “double-edged swords”, as they kill the cancer cells but also strike the healthy cells causing severe morbidity and sometimes also mortality. Could omega-3 fatty acids in this setting work as a “sword and shield” instead, by being cytotoxic to cancer cells, but at the same time protect healthy cells from these deleterious effects? In addition, may our current diet with decreased omega-3/omega-6 ratio contribute to the increased cancer incidence, and could an omega-3 enriched diet be used as a preventive measure against cancer?
Here, we seek answers to these questions by reviewing the effects of omega-3 fatty acids, particularly DHA, on various cancers with emphasis on a cancer of neural origin, neuroblastoma. Results from preventive and therapeutic animal as well as human studies together with mechanisms behind the observed toxicity are summarized. |
| doi_str_mv | 10.1016/j.yexcr.2010.02.039 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_552737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014482710001011</els_id><sourcerecordid>733960115</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-585c56fd8078e62ae247aad3c321d06b4028d373e57144802e64aa8fb3e1d1cb3</originalsourceid><addsrcrecordid>eNp9kctu1DAUQC1ERYeBL0CqLDZsyHD9SOIsKoQq-pAquoG15dg3raeZeGonhfn7us3QRRdd2bo-9-VDyCcGKwas-rZe7fCfjSsOOQJ8BaJ5QxYMGii45PwtWQAwWUjF60PyPqU1ACjFqnfkkANnjNV8QX5dbfDaFIJ2Zhx31FjvEvUDtWawGL_S8QbpNoYR7RhioqGj1yE4agb39HTr-x7nON77_vsHctCZPuHH_bkkf05__j45Ly6vzi5OflwWVqpmLEpV2rLqnIJaYcUNclkb44QVnDmoWglcOVELLGsmpQKOlTRGda1A5phtxZIUc930F7dTq7fRb0zc6WC83odu8w11WfI6F1qSLzOfd7mbMI1645PFvjcDhinpWoimAsbKTH5-Qa7DFIe8jFYlr_LAssmQmCEbQ0oRu-cBGOhHOXqtn-ToRzkauM5yctbRvvTUbtA95_y3kYHjGcD8dfceo07WYxbhfMwCtAv-1QYP3LifbA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>852607849</pqid></control><display><type>article</type><title>Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Gleissman, Helena ; Johnsen, John Inge ; Kogner, Per</creator><creatorcontrib>Gleissman, Helena ; Johnsen, John Inge ; Kogner, Per</creatorcontrib><description>Omega-3 fatty acids have been implicated in cancer prevention and treatment. Conventional chemotherapeutics are considered “double-edged swords”, as they kill the cancer cells but also strike the healthy cells causing severe morbidity and sometimes also mortality. Could omega-3 fatty acids in this setting work as a “sword and shield” instead, by being cytotoxic to cancer cells, but at the same time protect healthy cells from these deleterious effects? In addition, may our current diet with decreased omega-3/omega-6 ratio contribute to the increased cancer incidence, and could an omega-3 enriched diet be used as a preventive measure against cancer?
Here, we seek answers to these questions by reviewing the effects of omega-3 fatty acids, particularly DHA, on various cancers with emphasis on a cancer of neural origin, neuroblastoma. Results from preventive and therapeutic animal as well as human studies together with mechanisms behind the observed toxicity are summarized.</description><identifier>ISSN: 0014-4827</identifier><identifier>EISSN: 1090-2422</identifier><identifier>DOI: 10.1016/j.yexcr.2010.02.039</identifier><identifier>PMID: 20211172</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cancer ; Cellular biology ; Docosahexaenoic acid ; Docosanoids ; Eicosanoids ; Fatty acids ; Fatty Acids, Omega-3 - pharmacology ; Humans ; Neoplasms - prevention & control ; Omega-3 fatty acids ; Oncology ; Polyunsaturated fatty acids</subject><ispartof>Experimental cell research, 2010-05, Vol.316 (8), p.1365-1373</ispartof><rights>2010</rights><rights>Copyright 2010. Published by Elsevier Inc.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-585c56fd8078e62ae247aad3c321d06b4028d373e57144802e64aa8fb3e1d1cb3</citedby><cites>FETCH-LOGICAL-c489t-585c56fd8078e62ae247aad3c321d06b4028d373e57144802e64aa8fb3e1d1cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014482710001011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20211172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120457685$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Gleissman, Helena</creatorcontrib><creatorcontrib>Johnsen, John Inge</creatorcontrib><creatorcontrib>Kogner, Per</creatorcontrib><title>Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?</title><title>Experimental cell research</title><addtitle>Exp Cell Res</addtitle><description>Omega-3 fatty acids have been implicated in cancer prevention and treatment. Conventional chemotherapeutics are considered “double-edged swords”, as they kill the cancer cells but also strike the healthy cells causing severe morbidity and sometimes also mortality. Could omega-3 fatty acids in this setting work as a “sword and shield” instead, by being cytotoxic to cancer cells, but at the same time protect healthy cells from these deleterious effects? In addition, may our current diet with decreased omega-3/omega-6 ratio contribute to the increased cancer incidence, and could an omega-3 enriched diet be used as a preventive measure against cancer?
Here, we seek answers to these questions by reviewing the effects of omega-3 fatty acids, particularly DHA, on various cancers with emphasis on a cancer of neural origin, neuroblastoma. Results from preventive and therapeutic animal as well as human studies together with mechanisms behind the observed toxicity are summarized.</description><subject>Animals</subject><subject>Cancer</subject><subject>Cellular biology</subject><subject>Docosahexaenoic acid</subject><subject>Docosanoids</subject><subject>Eicosanoids</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Humans</subject><subject>Neoplasms - prevention & control</subject><subject>Omega-3 fatty acids</subject><subject>Oncology</subject><subject>Polyunsaturated fatty acids</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUQC1ERYeBL0CqLDZsyHD9SOIsKoQq-pAquoG15dg3raeZeGonhfn7us3QRRdd2bo-9-VDyCcGKwas-rZe7fCfjSsOOQJ8BaJ5QxYMGii45PwtWQAwWUjF60PyPqU1ACjFqnfkkANnjNV8QX5dbfDaFIJ2Zhx31FjvEvUDtWawGL_S8QbpNoYR7RhioqGj1yE4agb39HTr-x7nON77_vsHctCZPuHH_bkkf05__j45Ly6vzi5OflwWVqpmLEpV2rLqnIJaYcUNclkb44QVnDmoWglcOVELLGsmpQKOlTRGda1A5phtxZIUc930F7dTq7fRb0zc6WC83odu8w11WfI6F1qSLzOfd7mbMI1645PFvjcDhinpWoimAsbKTH5-Qa7DFIe8jFYlr_LAssmQmCEbQ0oRu-cBGOhHOXqtn-ToRzkauM5yctbRvvTUbtA95_y3kYHjGcD8dfceo07WYxbhfMwCtAv-1QYP3LifbA</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Gleissman, Helena</creator><creator>Johnsen, John Inge</creator><creator>Kogner, Per</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20100501</creationdate><title>Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?</title><author>Gleissman, Helena ; Johnsen, John Inge ; Kogner, Per</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-585c56fd8078e62ae247aad3c321d06b4028d373e57144802e64aa8fb3e1d1cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Cellular biology</topic><topic>Docosahexaenoic acid</topic><topic>Docosanoids</topic><topic>Eicosanoids</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Humans</topic><topic>Neoplasms - prevention & control</topic><topic>Omega-3 fatty acids</topic><topic>Oncology</topic><topic>Polyunsaturated fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gleissman, Helena</creatorcontrib><creatorcontrib>Johnsen, John Inge</creatorcontrib><creatorcontrib>Kogner, Per</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gleissman, Helena</au><au>Johnsen, John Inge</au><au>Kogner, Per</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>316</volume><issue>8</issue><spage>1365</spage><epage>1373</epage><pages>1365-1373</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><abstract>Omega-3 fatty acids have been implicated in cancer prevention and treatment. Conventional chemotherapeutics are considered “double-edged swords”, as they kill the cancer cells but also strike the healthy cells causing severe morbidity and sometimes also mortality. Could omega-3 fatty acids in this setting work as a “sword and shield” instead, by being cytotoxic to cancer cells, but at the same time protect healthy cells from these deleterious effects? In addition, may our current diet with decreased omega-3/omega-6 ratio contribute to the increased cancer incidence, and could an omega-3 enriched diet be used as a preventive measure against cancer?
Here, we seek answers to these questions by reviewing the effects of omega-3 fatty acids, particularly DHA, on various cancers with emphasis on a cancer of neural origin, neuroblastoma. Results from preventive and therapeutic animal as well as human studies together with mechanisms behind the observed toxicity are summarized.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20211172</pmid><doi>10.1016/j.yexcr.2010.02.039</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4827 |
| ispartof | Experimental cell research, 2010-05, Vol.316 (8), p.1365-1373 |
| issn | 0014-4827 1090-2422 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_552737 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cancer Cellular biology Docosahexaenoic acid Docosanoids Eicosanoids Fatty acids Fatty Acids, Omega-3 - pharmacology Humans Neoplasms - prevention & control Omega-3 fatty acids Oncology Polyunsaturated fatty acids |
| title | Omega-3 fatty acids in cancer, the protectors of good and the killers of evil? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T03%3A59%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Omega-3%20fatty%20acids%20in%20cancer,%20the%20protectors%20of%20good%20and%20the%20killers%20of%20evil?&rft.jtitle=Experimental%20cell%20research&rft.au=Gleissman,%20Helena&rft.date=2010-05-01&rft.volume=316&rft.issue=8&rft.spage=1365&rft.epage=1373&rft.pages=1365-1373&rft.issn=0014-4827&rft.eissn=1090-2422&rft_id=info:doi/10.1016/j.yexcr.2010.02.039&rft_dat=%3Cproquest_swepu%3E733960115%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=852607849&rft_id=info:pmid/20211172&rft_els_id=S0014482710001011&rfr_iscdi=true |