Protection of Cells in Physiological Oxygen Tensions against DNA Damage-induced Apoptosis

Oxygen availability has important effects on cell physiology. Although hyperoxic and hypoxic stresses have been well characterized, little is known about cellular functions in the oxygen levels commonly found in vivo. Here, we show that p53-dependent apoptosis in response to different DNA-damaging a...

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Veröffentlicht in:	JOURNAL OF BIOLOGICAL CHEMISTRY 2010-04, Vol.285 (18), p.13658-13665
Hauptverfasser:	Carrera, Samantha, de Verdier, Petra J., Khan, Zahid, Zhao, Bo, Mahale, Alka, Bowman, Karen J., Zainol, Muri, Jones, George D.D., Lee, Sam W., Aaronson, Stuart A., Macip, Salvador
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Biology Cell Hypoxia - genetics Cell Line, Tumor Cell Survival - genetics Diseases/Cancer DNA and Chromosomes DNA Damage Humans MAP Kinase Signaling System Mitogen-Activated Protein Kinase 3 - metabolism Models, Biological Oxygen Oxygen - metabolism Oxygen/Hypoxia Oxygen/Radicals Reactive Oxygen Species - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor/Suppressor/p53
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