Effect of blood redistribution on exhaled and alveolar nitric oxide: A hypergravity model study
Abstract Alveolar ( CANO ) and exhaled nitric oxide ( FENO ) concentrations, mainly regarded as inflammation surrogates, may also be affected by perfusion redistribution changing alveolar transfer factor ( DANO ). A model of blood redistribution is hypergravity, Karlsson et al. (2009b) found, at 2 G...
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2010-05, Vol.171 (3), p.187-192 |
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| creator | Kerckx, Yannick Karlsson, Lars L Linnarsson, Dag Van Muylem, Alain |
| description | Abstract Alveolar ( CANO ) and exhaled nitric oxide ( FENO ) concentrations, mainly regarded as inflammation surrogates, may also be affected by perfusion redistribution changing alveolar transfer factor ( DANO ). A model of blood redistribution is hypergravity, Karlsson et al. (2009b) found, at 2 G, increases of 22% and 70%, for FENO , and CANO , respectively. The present study aimed at theoretically estimating the amplitude of DANO changes that mimic these experimental data. An equation describing convection, diffusion and NO sources was solved in a 2-trumpet model (parallel dependent and non-dependent lung units). Acinar airways lumen reduction was also simulated. A reduction of 33% of the overall DANO (−51% in the non-dependent unit) along with a 36% reduction of acinar airways lumen reproduced experimental findings. In conclusion, substantial FENO and CANO increases may be accounted for by a decrease of the alveolo-capillaries contact surface, here hypergravity-induced. Acinar airway constriction may also have a part in the overall FENO increase. |
| doi_str_mv | 10.1016/j.resp.2010.04.005 |
| format | Article |
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A model of blood redistribution is hypergravity, Karlsson et al. (2009b) found, at 2 G, increases of 22% and 70%, for FENO , and CANO , respectively. The present study aimed at theoretically estimating the amplitude of DANO changes that mimic these experimental data. An equation describing convection, diffusion and NO sources was solved in a 2-trumpet model (parallel dependent and non-dependent lung units). Acinar airways lumen reduction was also simulated. A reduction of 33% of the overall DANO (−51% in the non-dependent unit) along with a 36% reduction of acinar airways lumen reproduced experimental findings. In conclusion, substantial FENO and CANO increases may be accounted for by a decrease of the alveolo-capillaries contact surface, here hypergravity-induced. Acinar airway constriction may also have a part in the overall FENO increase.</description><identifier>ISSN: 1569-9048</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2010.04.005</identifier><identifier>PMID: 20385259</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alveolar nitric oxide ; Back-diffusion ; Biological and medical sciences ; Breath Tests ; Exhalation ; Exhaled nitric oxide ; Fundamental and applied biological sciences. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-41bb9bb2fc7c7dce940f6e392d8cfcc1c269752438419d085499e1fbe19757003</citedby><cites>FETCH-LOGICAL-c478t-41bb9bb2fc7c7dce940f6e392d8cfcc1c269752438419d085499e1fbe19757003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.resp.2010.04.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22862355$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20385259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120906811$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kerckx, Yannick</creatorcontrib><creatorcontrib>Karlsson, Lars L</creatorcontrib><creatorcontrib>Linnarsson, Dag</creatorcontrib><creatorcontrib>Van Muylem, Alain</creatorcontrib><title>Effect of blood redistribution on exhaled and alveolar nitric oxide: A hypergravity model study</title><title>Respiratory physiology & neurobiology</title><addtitle>Respir Physiol Neurobiol</addtitle><description>Abstract Alveolar ( CANO ) and exhaled nitric oxide ( FENO ) concentrations, mainly regarded as inflammation surrogates, may also be affected by perfusion redistribution changing alveolar transfer factor ( DANO ). A model of blood redistribution is hypergravity, Karlsson et al. (2009b) found, at 2 G, increases of 22% and 70%, for FENO , and CANO , respectively. The present study aimed at theoretically estimating the amplitude of DANO changes that mimic these experimental data. An equation describing convection, diffusion and NO sources was solved in a 2-trumpet model (parallel dependent and non-dependent lung units). Acinar airways lumen reduction was also simulated. A reduction of 33% of the overall DANO (−51% in the non-dependent unit) along with a 36% reduction of acinar airways lumen reproduced experimental findings. In conclusion, substantial FENO and CANO increases may be accounted for by a decrease of the alveolo-capillaries contact surface, here hypergravity-induced. Acinar airway constriction may also have a part in the overall FENO increase.</description><subject>Alveolar nitric oxide</subject><subject>Back-diffusion</subject><subject>Biological and medical sciences</subject><subject>Breath Tests</subject><subject>Exhalation</subject><subject>Exhaled nitric oxide</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypergravity</subject><subject>Medical Education</subject><subject>Modelling</subject><subject>Models, Biological</subject><subject>Models, Theoretical</subject><subject>Nitric Oxide - metabolism</subject><subject>NO transfer factor</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Pulmonary Circulation - physiology</subject><subject>Pulmonary/Respiratory</subject><subject>Vertebrates: respiratory system</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkFvFSEQxzdGY2v1C3gwXIynfQILu2BMk6Zpq0kTD-qZsDBYXnnLCrvP7reXzXvWxIMJhMnkN39g_lNVrwneEEza99tNgjxuKC4JzDYY8yfVKRGdqAkn8mmJeStriZk4qV7kvMWYdKRrnlcnFDeCUy5PK3XlHJgJRYf6EKNFCazPU_L9PPk4oLLg4U4HsEgPZYc9xKATGnxhDIoP3sIHdIHulhHSj6T3flrQLloIKE-zXV5Wz5wOGV4dz7Pq-_XVt8tP9e2Xm8-XF7e1YZ2Yakb6XvY9daYznTUgGXYtNJJaYZwxxNBWdpyyRjAiLRacSQnE9UBKusO4Oavqg27-BePcqzH5nU6LitqrY-q-RKA4L5-nhX934McUf86QJ7Xz2UAIeoA4Z9U1DNNWYFFIeiBNijkncI_aBKvVB7VVqw9q9UFhpooPpejNUX7ud2AfS_40vgBvj4DORgeX9GB8_stR0dKGr0IfDxyU5u09JJWNh8EUl1LxTdno__-O83_KTfCDLzfewwJ5G-c0FFsUUZkqrL6uE7MODMFlWChnzW-3drwr</recordid><startdate>20100531</startdate><enddate>20100531</enddate><creator>Kerckx, Yannick</creator><creator>Karlsson, Lars L</creator><creator>Linnarsson, Dag</creator><creator>Van Muylem, Alain</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20100531</creationdate><title>Effect of blood redistribution on exhaled and alveolar nitric oxide: A hypergravity model study</title><author>Kerckx, Yannick ; Karlsson, Lars L ; Linnarsson, Dag ; Van Muylem, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-41bb9bb2fc7c7dce940f6e392d8cfcc1c269752438419d085499e1fbe19757003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Alveolar nitric oxide</topic><topic>Back-diffusion</topic><topic>Biological and medical sciences</topic><topic>Breath Tests</topic><topic>Exhalation</topic><topic>Exhaled nitric oxide</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypergravity</topic><topic>Medical Education</topic><topic>Modelling</topic><topic>Models, Biological</topic><topic>Models, Theoretical</topic><topic>Nitric Oxide - metabolism</topic><topic>NO transfer factor</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Pulmonary Circulation - physiology</topic><topic>Pulmonary/Respiratory</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kerckx, Yannick</creatorcontrib><creatorcontrib>Karlsson, Lars L</creatorcontrib><creatorcontrib>Linnarsson, Dag</creatorcontrib><creatorcontrib>Van Muylem, Alain</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerckx, Yannick</au><au>Karlsson, Lars L</au><au>Linnarsson, Dag</au><au>Van Muylem, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of blood redistribution on exhaled and alveolar nitric oxide: A hypergravity model study</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2010-05-31</date><risdate>2010</risdate><volume>171</volume><issue>3</issue><spage>187</spage><epage>192</epage><pages>187-192</pages><issn>1569-9048</issn><eissn>1878-1519</eissn><abstract>Abstract Alveolar ( CANO ) and exhaled nitric oxide ( FENO ) concentrations, mainly regarded as inflammation surrogates, may also be affected by perfusion redistribution changing alveolar transfer factor ( DANO ). A model of blood redistribution is hypergravity, Karlsson et al. (2009b) found, at 2 G, increases of 22% and 70%, for FENO , and CANO , respectively. The present study aimed at theoretically estimating the amplitude of DANO changes that mimic these experimental data. An equation describing convection, diffusion and NO sources was solved in a 2-trumpet model (parallel dependent and non-dependent lung units). Acinar airways lumen reduction was also simulated. A reduction of 33% of the overall DANO (−51% in the non-dependent unit) along with a 36% reduction of acinar airways lumen reproduced experimental findings. In conclusion, substantial FENO and CANO increases may be accounted for by a decrease of the alveolo-capillaries contact surface, here hypergravity-induced. Acinar airway constriction may also have a part in the overall FENO increase.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20385259</pmid><doi>10.1016/j.resp.2010.04.005</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alveolar nitric oxide Back-diffusion Biological and medical sciences Breath Tests Exhalation Exhaled nitric oxide Fundamental and applied biological sciences. Psychology Hypergravity Medical Education Modelling Models, Biological Models, Theoretical Nitric Oxide - metabolism NO transfer factor Pulmonary Alveoli - metabolism Pulmonary Circulation - physiology Pulmonary/Respiratory Vertebrates: respiratory system |
| title | Effect of blood redistribution on exhaled and alveolar nitric oxide: A hypergravity model study |
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