Interobserver and intraobserver variability in the response evaluation of cancer therapy according to RECIST and WHO-criteria
Abstract Background. Response Evaluation Criteria In Solid Tumors (RECIST) and WHO-criteria are used to evaluate treatment effects in clinical trials. The purpose of this study was to examine interobserver and intraobserver variations in radiological response assessment using these criteria. Materia...
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| Veröffentlicht in: | Acta oncologica 2010, Vol.49 (4), p.509-514 |
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| creator | Suzuki, Chikako Torkzad, Michael R. Jacobsson, Hans Åström, Gunnar Sundin, Anders Hatschek, Thomas Fujii, Hirofumi Blomqvist, Lennart |
| description | Abstract
Background. Response Evaluation Criteria In Solid Tumors (RECIST) and WHO-criteria are used to evaluate treatment effects in clinical trials. The purpose of this study was to examine interobserver and intraobserver variations in radiological response assessment using these criteria. Material and methods. Thirty-nine patients were eligible. Each patient's series of CT images were reviewed. Each patient was classified into one of four categories according RECIST and WHO-criteria. To examine interobserver variation, response classifications were independently obtained by two radiologists. One radiologist repeated the procedure on two additional different occasions to examine intraobserver variation. Kappa statistics was applied to examine agreement. Results. Interobserver variation using RECIST and WHO-criteria were 0.53 (95% CI 0.33-0.72) and 0.60 (0.39-0.80), respectively. Response rates (RR) according to RECIST obtained by reader A and reader B were 33% and 21%, respectively. RR according to WHO-criteria obtained by reader A and reader B were 33% and 23% respectively. Intraobserver variation using RECIST and WHO-criteria ranged between 0.76-0.96 and 0.86-0.91, respectively. Conclusion. Radiological tumor response evaluation according to RECIST and WHO-criteria are subject to considerable inter- and intraobserver variability. Efforts are necessary to reduce inconsistencies from current response evaluation criteria. |
| doi_str_mv | 10.3109/02841861003705794 |
| format | Article |
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Background. Response Evaluation Criteria In Solid Tumors (RECIST) and WHO-criteria are used to evaluate treatment effects in clinical trials. The purpose of this study was to examine interobserver and intraobserver variations in radiological response assessment using these criteria. Material and methods. Thirty-nine patients were eligible. Each patient's series of CT images were reviewed. Each patient was classified into one of four categories according RECIST and WHO-criteria. To examine interobserver variation, response classifications were independently obtained by two radiologists. One radiologist repeated the procedure on two additional different occasions to examine intraobserver variation. Kappa statistics was applied to examine agreement. Results. Interobserver variation using RECIST and WHO-criteria were 0.53 (95% CI 0.33-0.72) and 0.60 (0.39-0.80), respectively. Response rates (RR) according to RECIST obtained by reader A and reader B were 33% and 21%, respectively. RR according to WHO-criteria obtained by reader A and reader B were 33% and 23% respectively. Intraobserver variation using RECIST and WHO-criteria ranged between 0.76-0.96 and 0.86-0.91, respectively. Conclusion. Radiological tumor response evaluation according to RECIST and WHO-criteria are subject to considerable inter- and intraobserver variability. Efforts are necessary to reduce inconsistencies from current response evaluation criteria.</description><identifier>ISSN: 0284-186X</identifier><identifier>ISSN: 1651-226X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/02841861003705794</identifier><identifier>PMID: 20397778</identifier><language>eng</language><publisher>England: Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)</publisher><subject>Adult ; Aged ; Clinical Trials as Topic - statistics & numerical data ; Disease-Free Survival ; Female ; Humans ; Image Interpretation, Computer-Assisted - standards ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Neoplasms - diagnostic imaging ; Observer Variation ; Quality Indicators, Health Care ; Retrospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome ; World Health Organization</subject><ispartof>Acta oncologica, 2010, Vol.49 (4), p.509-514</ispartof><rights>Informa UK Ltd 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-4aecdf211945cfeae056ab61df81625a3aae225aba05e93c07eec8246c86596b3</citedby><cites>FETCH-LOGICAL-c520t-4aecdf211945cfeae056ab61df81625a3aae225aba05e93c07eec8246c86596b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02841861003705794$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02841861003705794$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,780,784,885,4023,27922,27923,27924,61220,61401</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20397778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160752$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120327431$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Chikako</creatorcontrib><creatorcontrib>Torkzad, Michael R.</creatorcontrib><creatorcontrib>Jacobsson, Hans</creatorcontrib><creatorcontrib>Åström, Gunnar</creatorcontrib><creatorcontrib>Sundin, Anders</creatorcontrib><creatorcontrib>Hatschek, Thomas</creatorcontrib><creatorcontrib>Fujii, Hirofumi</creatorcontrib><creatorcontrib>Blomqvist, Lennart</creatorcontrib><title>Interobserver and intraobserver variability in the response evaluation of cancer therapy according to RECIST and WHO-criteria</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Abstract
Background. Response Evaluation Criteria In Solid Tumors (RECIST) and WHO-criteria are used to evaluate treatment effects in clinical trials. The purpose of this study was to examine interobserver and intraobserver variations in radiological response assessment using these criteria. Material and methods. Thirty-nine patients were eligible. Each patient's series of CT images were reviewed. Each patient was classified into one of four categories according RECIST and WHO-criteria. To examine interobserver variation, response classifications were independently obtained by two radiologists. One radiologist repeated the procedure on two additional different occasions to examine intraobserver variation. Kappa statistics was applied to examine agreement. Results. Interobserver variation using RECIST and WHO-criteria were 0.53 (95% CI 0.33-0.72) and 0.60 (0.39-0.80), respectively. Response rates (RR) according to RECIST obtained by reader A and reader B were 33% and 21%, respectively. RR according to WHO-criteria obtained by reader A and reader B were 33% and 23% respectively. Intraobserver variation using RECIST and WHO-criteria ranged between 0.76-0.96 and 0.86-0.91, respectively. Conclusion. Radiological tumor response evaluation according to RECIST and WHO-criteria are subject to considerable inter- and intraobserver variability. Efforts are necessary to reduce inconsistencies from current response evaluation criteria.</description><subject>Adult</subject><subject>Aged</subject><subject>Clinical Trials as Topic - statistics & numerical data</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - standards</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Observer Variation</subject><subject>Quality Indicators, Health Care</subject><subject>Retrospective Studies</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>World Health Organization</subject><issn>0284-186X</issn><issn>1651-226X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ksFu1DAQhi0EotvCA3BBvnEhYDuxnYhTtRS6UqVKUKA3a-JMui7ZOLWTRXvou-Nlt8sBldNYnu_7R7KHkFecvcs5q94zURa8VJyxXDOpq-IJmXEleSaEun5KZtt-loDrI3Ic4y1jTORaPidHguWV1rqckftFP2LwdcSwxkChb6jrxwCHmzUEB7Xr3LhJHToukQaMg-8jUlxDN8HofE99Sy30NgmJCDBsKFjrQ-P6Gzp6-uVsvvh69Sf-x_llZoNLUx28IM9a6CK-3NcT8u3T2dX8PLu4_LyYn15kVgo2ZgWgbVrBeVVI2yIgkwpqxZu25EpIyAFQpFoDk1jllmlEW4pC2VLJStX5Ccl2ufEXDlNthuBWEDbGgzP7q5_phEbKNIMnvnqUH4Jv_koPIk9PKnSRb923j7of3fdT48ONmSbDFdNSJPzNDk-5dxPG0axctNh10KOfotF5zouyLHUi-Y60wccYsD1Ec2a2-2D-2YfkvN6nT_UKm4PxsAAJ-LADXN_6sIIlQjcuLQQ0t34KffqV_8T_BrAvxqQ</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Suzuki, Chikako</creator><creator>Torkzad, Michael R.</creator><creator>Jacobsson, Hans</creator><creator>Åström, Gunnar</creator><creator>Sundin, Anders</creator><creator>Hatschek, Thomas</creator><creator>Fujii, Hirofumi</creator><creator>Blomqvist, Lennart</creator><general>Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>2010</creationdate><title>Interobserver and intraobserver variability in the response evaluation of cancer therapy according to RECIST and WHO-criteria</title><author>Suzuki, Chikako ; Torkzad, Michael R. ; Jacobsson, Hans ; Åström, Gunnar ; Sundin, Anders ; Hatschek, Thomas ; Fujii, Hirofumi ; Blomqvist, Lennart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-4aecdf211945cfeae056ab61df81625a3aae225aba05e93c07eec8246c86596b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Clinical Trials as Topic - statistics & numerical data</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - standards</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Observer Variation</topic><topic>Quality Indicators, Health Care</topic><topic>Retrospective Studies</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>World Health Organization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Chikako</creatorcontrib><creatorcontrib>Torkzad, Michael R.</creatorcontrib><creatorcontrib>Jacobsson, Hans</creatorcontrib><creatorcontrib>Åström, Gunnar</creatorcontrib><creatorcontrib>Sundin, Anders</creatorcontrib><creatorcontrib>Hatschek, Thomas</creatorcontrib><creatorcontrib>Fujii, Hirofumi</creatorcontrib><creatorcontrib>Blomqvist, Lennart</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Chikako</au><au>Torkzad, Michael R.</au><au>Jacobsson, Hans</au><au>Åström, Gunnar</au><au>Sundin, Anders</au><au>Hatschek, Thomas</au><au>Fujii, Hirofumi</au><au>Blomqvist, Lennart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interobserver and intraobserver variability in the response evaluation of cancer therapy according to RECIST and WHO-criteria</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>2010</date><risdate>2010</risdate><volume>49</volume><issue>4</issue><spage>509</spage><epage>514</epage><pages>509-514</pages><issn>0284-186X</issn><issn>1651-226X</issn><eissn>1651-226X</eissn><abstract>Abstract
Background. Response Evaluation Criteria In Solid Tumors (RECIST) and WHO-criteria are used to evaluate treatment effects in clinical trials. The purpose of this study was to examine interobserver and intraobserver variations in radiological response assessment using these criteria. Material and methods. Thirty-nine patients were eligible. Each patient's series of CT images were reviewed. Each patient was classified into one of four categories according RECIST and WHO-criteria. To examine interobserver variation, response classifications were independently obtained by two radiologists. One radiologist repeated the procedure on two additional different occasions to examine intraobserver variation. Kappa statistics was applied to examine agreement. Results. Interobserver variation using RECIST and WHO-criteria were 0.53 (95% CI 0.33-0.72) and 0.60 (0.39-0.80), respectively. Response rates (RR) according to RECIST obtained by reader A and reader B were 33% and 21%, respectively. RR according to WHO-criteria obtained by reader A and reader B were 33% and 23% respectively. Intraobserver variation using RECIST and WHO-criteria ranged between 0.76-0.96 and 0.86-0.91, respectively. Conclusion. Radiological tumor response evaluation according to RECIST and WHO-criteria are subject to considerable inter- and intraobserver variability. Efforts are necessary to reduce inconsistencies from current response evaluation criteria.</abstract><cop>England</cop><pub>Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)</pub><pmid>20397778</pmid><doi>10.3109/02841861003705794</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0284-186X |
| ispartof | Acta oncologica, 2010, Vol.49 (4), p.509-514 |
| issn | 0284-186X 1651-226X 1651-226X |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_551941 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Taylor & Francis:Master (3349 titles); Alma/SFX Local Collection |
| subjects | Adult Aged Clinical Trials as Topic - statistics & numerical data Disease-Free Survival Female Humans Image Interpretation, Computer-Assisted - standards Male Medicin och hälsovetenskap Middle Aged Neoplasms - diagnostic imaging Observer Variation Quality Indicators, Health Care Retrospective Studies Tomography, X-Ray Computed Treatment Outcome World Health Organization |
| title | Interobserver and intraobserver variability in the response evaluation of cancer therapy according to RECIST and WHO-criteria |
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