Dendritic cells are able to produce IL-12p70 after uptake of apoptotic cells

Abstract Dendritic cell derived IL-12p70 stimulates IFN-γ production in naïve T cells, thereby promoting Th1 responses, which counteracts induction of tolerance. Uptake of apoptotic cells by dendritic cells is generally considered to induce tolerance rather than immune activation and has been shown...

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Veröffentlicht in:	Immunobiology (1979) 2011-01, Vol.216 (1), p.251-255
Hauptverfasser:	Johansson, Ulrika, Walther-Jallow, Lilian, Hofmann, Anette, Spetz, Anna-Lena
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Apoptosis CD40 Antigens - immunology CD40 Antigens - metabolism CD40 Ligand - genetics CD40 Ligand - immunology CD40 Ligand - metabolism Cell activation Cells, Cultured Cytophagocytosis - immunology Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Humans IL-12p70 Interferon-gamma - secretion Interleukin-12 - genetics Interleukin-12 - metabolism Lymphocyte Activation Medicin och hälsovetenskap Phagocytosis Protein Binding - immunology Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - pathology
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