Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity

Although saturated and monounsaturated very-long-chain fatty acids (VLCFAs) have long been associated with undesirable effects on health, including obesity, heart failure, and atherosclerosis, the physiological role of endogenous synthesis is largely unknown. The fatty acid elongase ELOVL3 is involv...

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Veröffentlicht in:	The FASEB journal 2010-11, Vol.24 (11), p.4366-4377
Hauptverfasser:	Zadravec, Damir, Brolinson, Annelie, Fisher, Rachel M, Carneheim, Claes, Csikasz, Robert I, Bertrand-Michel, Justine, Borén, Jan, Guillou, Hervé, Rudling, Mats, Jacobsso, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases Acetyltransferases - genetics Acetyltransferases - metabolism Adipokines Adipokines - secretion Adiponectin Adiponectin - blood Adipose Tissue Adipose Tissue - metabolism Animals Basal Metabolism Basal Metabolism - genetics biosynthesis blood Cardiology and Cardiovascular Disease Cells Cells, Cultured Cultured Diet Eating Eating - genetics Enzymologic enzymology fatty acid synthesis Female gender Gene Expression Regulation Gene Expression Regulation, Enzymologic genetics Inbred C57BL Kardiologi och kardiovaskulära sjukdomar Knockout Life Sciences Lipogenesis Lipogenesis - genetics Lipoproteins Lipoproteins, VLDL - biosynthesis Lipoproteins, VLDL - blood Liver Liver - metabolism Male Medical Genetics and Genomics Medicinsk genetik och genomik metabolism Mice Mice, Inbred C57BL Mice, Knockout Obesity Obesity - enzymology Obesity - metabolism secretion Sex Factors Triglycerides Triglycerides - biosynthesis Triglycerides - blood VLCFA VLDL
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