Impact of restricted amoxicillin/clavulanic acid use on Escherichia coli resistance—antibiotic DU90% profiles with bacterial resistance rates: a visual presentation
Abstract High use of amoxicillin/clavulanic acid (AMC) at the University Hospital Osijek (Croatia) contributed to high rates of resistance in Enterobacteriaceae, in particular Escherichia coli (50%). Thus, in order to decrease bacterial resistance, AMC use was restricted. We present results of the r...
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| Veröffentlicht in: | International journal of antimicrobial agents 2010-10, Vol.36 (4), p.369-373 |
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| creator | Mimica Matanovic, Suzana Bergman, Ulf Vukovic, Dubravka Wettermark, Björn Vlahovic-Palcevski, Vera |
| description | Abstract High use of amoxicillin/clavulanic acid (AMC) at the University Hospital Osijek (Croatia) contributed to high rates of resistance in Enterobacteriaceae, in particular Escherichia coli (50%). Thus, in order to decrease bacterial resistance, AMC use was restricted. We present results of the restriction on resistance amongst antibiotics accounting for 90% of antibiotic use [drug utilisation 90% (DU90%)]. Data were analysed on antibiotic use and microbiological susceptibility of E. coli during two 9-month periods, before and after the restriction of AMC use. Drug use was presented as numbers of defined daily doses (DDDs) and DDDs/100 bed-days. Resistance of E. coli to antibiotics was presented as percentages of isolated strains in the DU90% segment. Use of AMC was 16 DDDs/100 bed-days or 30% of all antibiotics before the intervention. Use of AMC fell to 2 DDDs/100 bed-days or 4% after the intervention, and resistance of E. coli fell from 37% to 11%. In conclusion, restricted use of AMC resulted in a significant decrease of E. coli resistance. DU90% resistance profiles are simple and useful tools in highlighting problems in antibiotic use and resistance but may also be useful in long-term follow-up of antibiotic policy. |
| doi_str_mv | 10.1016/j.ijantimicag.2010.05.019 |
| format | Article |
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Thus, in order to decrease bacterial resistance, AMC use was restricted. We present results of the restriction on resistance amongst antibiotics accounting for 90% of antibiotic use [drug utilisation 90% (DU90%)]. Data were analysed on antibiotic use and microbiological susceptibility of E. coli during two 9-month periods, before and after the restriction of AMC use. Drug use was presented as numbers of defined daily doses (DDDs) and DDDs/100 bed-days. Resistance of E. coli to antibiotics was presented as percentages of isolated strains in the DU90% segment. Use of AMC was 16 DDDs/100 bed-days or 30% of all antibiotics before the intervention. Use of AMC fell to 2 DDDs/100 bed-days or 4% after the intervention, and resistance of E. coli fell from 37% to 11%. In conclusion, restricted use of AMC resulted in a significant decrease of E. coli resistance. DU90% resistance profiles are simple and useful tools in highlighting problems in antibiotic use and resistance but may also be useful in long-term follow-up of antibiotic policy.</description><identifier>ISSN: 0924-8579</identifier><identifier>ISSN: 1872-7913</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2010.05.019</identifier><identifier>PMID: 20688486</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amoxicillin ; Amoxicillin - pharmacology ; Amoxicillin - therapeutic use ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotic policy ; Antibiotic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial Infections - drug therapy ; Biological and medical sciences ; Clavulanic Acid - pharmacology ; Clavulanic Acid - therapeutic use ; Croatia ; Drug Resistance, Bacterial ; Drug Utilization - statistics & numerical data ; Enterobacteriaceae ; Escherichia coli - drug effects ; Health Policy ; Hospital care ; Hospitals, University - statistics & numerical data ; Humans ; Infectious Disease ; Medical sciences ; Medicin och hälsovetenskap ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Quality assessment ; Resistance</subject><ispartof>International journal of antimicrobial agents, 2010-10, Vol.36 (4), p.369-373</ispartof><rights>Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2010 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-8fa421f3d7051ff789ec101cf08613b5600d75a3785d492245bacc05e7d247b43</citedby><cites>FETCH-LOGICAL-c581t-8fa421f3d7051ff789ec101cf08613b5600d75a3785d492245bacc05e7d247b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijantimicag.2010.05.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23213303$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20688486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:121199880$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Mimica Matanovic, Suzana</creatorcontrib><creatorcontrib>Bergman, Ulf</creatorcontrib><creatorcontrib>Vukovic, Dubravka</creatorcontrib><creatorcontrib>Wettermark, Björn</creatorcontrib><creatorcontrib>Vlahovic-Palcevski, Vera</creatorcontrib><title>Impact of restricted amoxicillin/clavulanic acid use on Escherichia coli resistance—antibiotic DU90% profiles with bacterial resistance rates: a visual presentation</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>Abstract High use of amoxicillin/clavulanic acid (AMC) at the University Hospital Osijek (Croatia) contributed to high rates of resistance in Enterobacteriaceae, in particular Escherichia coli (50%). Thus, in order to decrease bacterial resistance, AMC use was restricted. We present results of the restriction on resistance amongst antibiotics accounting for 90% of antibiotic use [drug utilisation 90% (DU90%)]. Data were analysed on antibiotic use and microbiological susceptibility of E. coli during two 9-month periods, before and after the restriction of AMC use. Drug use was presented as numbers of defined daily doses (DDDs) and DDDs/100 bed-days. Resistance of E. coli to antibiotics was presented as percentages of isolated strains in the DU90% segment. Use of AMC was 16 DDDs/100 bed-days or 30% of all antibiotics before the intervention. Use of AMC fell to 2 DDDs/100 bed-days or 4% after the intervention, and resistance of E. coli fell from 37% to 11%. In conclusion, restricted use of AMC resulted in a significant decrease of E. coli resistance. DU90% resistance profiles are simple and useful tools in highlighting problems in antibiotic use and resistance but may also be useful in long-term follow-up of antibiotic policy.</description><subject>Amoxicillin</subject><subject>Amoxicillin - pharmacology</subject><subject>Amoxicillin - therapeutic use</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotic policy</subject><subject>Antibiotic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial Infections - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Clavulanic Acid - pharmacology</subject><subject>Clavulanic Acid - therapeutic use</subject><subject>Croatia</subject><subject>Drug Resistance, Bacterial</subject><subject>Drug Utilization - statistics & numerical data</subject><subject>Enterobacteriaceae</subject><subject>Escherichia coli - drug effects</subject><subject>Health Policy</subject><subject>Hospital care</subject><subject>Hospitals, University - statistics & numerical data</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Quality assessment</subject><subject>Resistance</subject><issn>0924-8579</issn><issn>1872-7913</issn><issn>1872-7913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEokvhFZA5VJyyHdtxYnNAQkuBSpU4QM-W4zjsbLPJEidbeuMheAYejCdhot12KyQEp0T299njmT9JXnCYc-D56WqOK9cOuEbvvswF0DqoOXDzIJlxXYi0MFw-TGZgRJZqVZij5EmMKwCuZKYeJ0cCcq0znc-Sn-frjfMD62rWhzj06IdQMbfuvqHHpsH21DduOzauRc-cx4qNMbCuZWfRLwPhS3TMdw1OOsbBtT78-v5jqq7EbiDp7aWBE7bpuxqbENk1DktW0pUku-aexXo3hPiKObbFONLWhvZCO7gBu_Zp8qh2TQzP9t_j5PLd2efFh_Ti4_vzxZuL1CvNh1TXLhO8llUBitd1oU3w1DFfg865LFUOUBXKyUKrKjNCZIoq8aBCUYmsKDN5nKS7c-N12Iyl3fS4dv2N7Rza_dIV_QWrMpNrQ7z5K09Prg7SrcgF58ZoDeS-3LkEfh2p-XaN0YeGeh26MVotTZ7nCtQ_ySIzIITh6lCP77sY-1DfVcTBTtmxK3svO3bKjgVlKTvkPt_fMpbrUN2Zt2Eh4GQPuOhdU_c0NowHTgouJUjiFjsu0KS2GHobPQYacYV98IOtOvyvcl7_cYqnOBLWXIWbEFfd2LcUBcttFBbspynsU9Y5AIhMavkb824Cig</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Mimica Matanovic, Suzana</creator><creator>Bergman, Ulf</creator><creator>Vukovic, Dubravka</creator><creator>Wettermark, Björn</creator><creator>Vlahovic-Palcevski, Vera</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20101001</creationdate><title>Impact of restricted amoxicillin/clavulanic acid use on Escherichia coli resistance—antibiotic DU90% profiles with bacterial resistance rates: a visual presentation</title><author>Mimica Matanovic, Suzana ; Bergman, Ulf ; Vukovic, Dubravka ; Wettermark, Björn ; Vlahovic-Palcevski, Vera</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-8fa421f3d7051ff789ec101cf08613b5600d75a3785d492245bacc05e7d247b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amoxicillin</topic><topic>Amoxicillin - pharmacology</topic><topic>Amoxicillin - therapeutic use</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotic policy</topic><topic>Antibiotic use</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial Infections - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Clavulanic Acid - pharmacology</topic><topic>Clavulanic Acid - therapeutic use</topic><topic>Croatia</topic><topic>Drug Resistance, Bacterial</topic><topic>Drug Utilization - statistics & numerical data</topic><topic>Enterobacteriaceae</topic><topic>Escherichia coli - drug effects</topic><topic>Health Policy</topic><topic>Hospital care</topic><topic>Hospitals, University - statistics & numerical data</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. 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Thus, in order to decrease bacterial resistance, AMC use was restricted. We present results of the restriction on resistance amongst antibiotics accounting for 90% of antibiotic use [drug utilisation 90% (DU90%)]. Data were analysed on antibiotic use and microbiological susceptibility of E. coli during two 9-month periods, before and after the restriction of AMC use. Drug use was presented as numbers of defined daily doses (DDDs) and DDDs/100 bed-days. Resistance of E. coli to antibiotics was presented as percentages of isolated strains in the DU90% segment. Use of AMC was 16 DDDs/100 bed-days or 30% of all antibiotics before the intervention. Use of AMC fell to 2 DDDs/100 bed-days or 4% after the intervention, and resistance of E. coli fell from 37% to 11%. In conclusion, restricted use of AMC resulted in a significant decrease of E. coli resistance. DU90% resistance profiles are simple and useful tools in highlighting problems in antibiotic use and resistance but may also be useful in long-term follow-up of antibiotic policy.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20688486</pmid><doi>10.1016/j.ijantimicag.2010.05.019</doi><tpages>5</tpages></addata></record> |
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| subjects | Amoxicillin Amoxicillin - pharmacology Amoxicillin - therapeutic use Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic policy Antibiotic use Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - drug therapy Biological and medical sciences Clavulanic Acid - pharmacology Clavulanic Acid - therapeutic use Croatia Drug Resistance, Bacterial Drug Utilization - statistics & numerical data Enterobacteriaceae Escherichia coli - drug effects Health Policy Hospital care Hospitals, University - statistics & numerical data Humans Infectious Disease Medical sciences Medicin och hälsovetenskap Microbial Sensitivity Tests Pharmacology. Drug treatments Quality assessment Resistance |
| title | Impact of restricted amoxicillin/clavulanic acid use on Escherichia coli resistance—antibiotic DU90% profiles with bacterial resistance rates: a visual presentation |
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