Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study
Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of...
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| Veröffentlicht in: | European journal of clinical nutrition 2011-01, Vol.65 (1), p.102-109 |
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| creator | Pincikova, T Nilsson, K Moen, I.E Karpati, F Fluge, G Hollsing, A Knudsen, P.K Lindblad, A Mared, L Pressler, T Hjelte, L |
| description | Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53–65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1λs (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and body mass index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R 2=0.376; beta=−0.02; P |
| doi_str_mv | 10.1038/ejcn.2010.194 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_548848</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A246100166</galeid><sourcerecordid>A246100166</sourcerecordid><originalsourceid>FETCH-LOGICAL-c802t-bb10ac4e5bd808719b97e56783ae3bb2e719601beddc25e30808625ed7fe7cec3</originalsourceid><addsrcrecordid>eNp9k01v1DAQhiMEoqVw5ApRER8HtjhxPpxj1dJSqYJDKVfLdiapi2MvdrzV_nsm3aXboraKnDgzz7we2zNJ8jojexmh7AtcKruXk-m3KZ4k21lRV7OyKsjTZJs0ZTGjhNRbyYsQLglBZ50_T7ZywsoGHdvJ8sQuwAdIPRgxamdTCeMVgE0XehSDtulhKmybBvBxSEc3CpPqYYjW9cbJaBA4TvE1XkB6ppDUViy0sOnBMoxapUdaehd0SL_H0etpARQ4G2O7fJk864QJ8Gr93UnOj77-PPg2O_1xfHKwfzpTjOTjTMqMCFVAKVtGWJ01sqmhrGpGBVApc0BTRTIJbavyEihBqsJJW3dQK1B0J5mtdMMVzKPkc68H4ZfcCc3Xpt84A14WjBUM-dMHeRPnOCSOKUCWVYN5lbyWpOFFRTuO2REuRU1Vx9pGZvDo8j3Koam_VssKmmc58p8f5A_1r33ufM9jRLyp8ynbjyt87t2fCGHkgw4KjBEWXAyc5XlNGmSR_PQomZGGFnVJKoLo7n_opYseb-5ajzKsogl6t4J6YYBr27nRCzVp8v28qDKstqrabP8O1YMFL4yz0Gk03-H37uHxaWHQ6t6AD7cCLkCY8SI4E6dSC_dmorAgg4fu5mgzwqdW4lMr8amVOLYS8m_WhxDlAO0N_a93EHi_BkRQwnReWKXDhqMMC7O8taWALtuD35zmQyu_XQV0wnHRexQ9P0MvJVmTY-lX9C9Q7T5M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>822384770</pqid></control><display><type>article</type><title>Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Pincikova, T ; Nilsson, K ; Moen, I.E ; Karpati, F ; Fluge, G ; Hollsing, A ; Knudsen, P.K ; Lindblad, A ; Mared, L ; Pressler, T ; Hjelte, L</creator><creatorcontrib>Pincikova, T ; Nilsson, K ; Moen, I.E ; Karpati, F ; Fluge, G ; Hollsing, A ; Knudsen, P.K ; Lindblad, A ; Mared, L ; Pressler, T ; Hjelte, L ; Scandinavian Cystic Fibrosis Study Consortium ; for the Scandinavian Cystic Fibrosis Study Consortium (SCFSC)</creatorcontrib><description>Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53–65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1λs (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and body mass index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R 2=0.376; beta=−0.02; P<0.001), supplemented vitamin D intake per kg bodyweight (adjusted R 2=0.375; beta=−0.82; P<0.001) and total vitamin D intake per kg bodyweight (adjusted R 2=0.398; beta=−0.60; P=0.002). Serum 25OHD was positively associated with FEV1 (adjusted R 2=0.308; beta=0.0007; P=0.025). Conclusions: Increasing vitamin D intake may positively modulate inflammation in CF. This study supports the proposed role of vitamin D in the immune system during infection and substantiates prospective studies.</description><identifier>ISSN: 0954-3007</identifier><identifier>ISSN: 1476-5640</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2010.194</identifier><identifier>PMID: 20859300</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject><![CDATA[25-hydroxycholecalciferol ; 631/250 ; 692/699/1785 ; 692/700/459/1994 ; administration & dosage ; Adolescent ; Adult ; Aged ; Alfacalcidol ; analogs & derivatives ; Antibiotics ; Biological and medical sciences ; blood ; Calcifediol ; Care and treatment ; Child ; Child, Preschool ; Clinical Nutrition ; Colonization ; Correlation analysis ; Cross-Sectional Studies ; Cystic Fibrosis ; Cystic Fibrosis - blood ; Cystic Fibrosis - immunology ; Cystic Fibrosis - metabolism ; Denmark ; Denmark - epidemiology ; Dietary Supplements ; disease severity ; Epidemiology ; Ergocalciferols ; Ergocalciferols - administration & dosage ; Ergocalciferols - blood ; Errors of metabolism ; Feeding. Feeding behavior ; Female ; Food ; forced expiratory flow rates ; Fundamental and applied biological sciences. Psychology ; Health Sciences ; human diseases ; human nutrition ; Humans ; Hälsovetenskap ; Immune system ; immunity ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulins ; immunology ; Infant ; inflammation ; Inflammatory diseases ; Internal Medicine ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Medicine & Public Health ; Metabolic Diseases ; metabolism ; Middle Aged ; Miscellaneous hereditary metabolic disorders ; Norway ; Norway - epidemiology ; nutrient intake ; Nutrition and Dietetics ; Nutritional Status ; Näringslära ; original-article ; patients ; Pediatrics ; Pediatrik ; Preschool ; Properties ; Public Health ; Regression Analysis ; respiratory tract diseases ; Scandinavian Cystic Fibrosis Nutritional Study ; Sweden ; Sweden - epidemiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; vitamin supplements ; Young Adult]]></subject><ispartof>European journal of clinical nutrition, 2011-01, Vol.65 (1), p.102-109</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c802t-bb10ac4e5bd808719b97e56783ae3bb2e719601beddc25e30808625ed7fe7cec3</citedby><cites>FETCH-LOGICAL-c802t-bb10ac4e5bd808719b97e56783ae3bb2e719601beddc25e30808625ed7fe7cec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2010.194$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2010.194$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23896056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20859300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149728$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/143212$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1869802$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122079451$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Pincikova, T</creatorcontrib><creatorcontrib>Nilsson, K</creatorcontrib><creatorcontrib>Moen, I.E</creatorcontrib><creatorcontrib>Karpati, F</creatorcontrib><creatorcontrib>Fluge, G</creatorcontrib><creatorcontrib>Hollsing, A</creatorcontrib><creatorcontrib>Knudsen, P.K</creatorcontrib><creatorcontrib>Lindblad, A</creatorcontrib><creatorcontrib>Mared, L</creatorcontrib><creatorcontrib>Pressler, T</creatorcontrib><creatorcontrib>Hjelte, L</creatorcontrib><creatorcontrib>Scandinavian Cystic Fibrosis Study Consortium</creatorcontrib><creatorcontrib>for the Scandinavian Cystic Fibrosis Study Consortium (SCFSC)</creatorcontrib><title>Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53–65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1λs (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and body mass index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R 2=0.376; beta=−0.02; P<0.001), supplemented vitamin D intake per kg bodyweight (adjusted R 2=0.375; beta=−0.82; P<0.001) and total vitamin D intake per kg bodyweight (adjusted R 2=0.398; beta=−0.60; P=0.002). Serum 25OHD was positively associated with FEV1 (adjusted R 2=0.308; beta=0.0007; P=0.025). Conclusions: Increasing vitamin D intake may positively modulate inflammation in CF. This study supports the proposed role of vitamin D in the immune system during infection and substantiates prospective studies.</description><subject>25-hydroxycholecalciferol</subject><subject>631/250</subject><subject>692/699/1785</subject><subject>692/700/459/1994</subject><subject>administration & dosage</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alfacalcidol</subject><subject>analogs & derivatives</subject><subject>Antibiotics</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Calcifediol</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Nutrition</subject><subject>Colonization</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Cystic Fibrosis</subject><subject>Cystic Fibrosis - blood</subject><subject>Cystic Fibrosis - immunology</subject><subject>Cystic Fibrosis - metabolism</subject><subject>Denmark</subject><subject>Denmark - epidemiology</subject><subject>Dietary Supplements</subject><subject>disease severity</subject><subject>Epidemiology</subject><subject>Ergocalciferols</subject><subject>Ergocalciferols - administration & dosage</subject><subject>Ergocalciferols - blood</subject><subject>Errors of metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food</subject><subject>forced expiratory flow rates</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health Sciences</subject><subject>human diseases</subject><subject>human nutrition</subject><subject>Humans</subject><subject>Hälsovetenskap</subject><subject>Immune system</subject><subject>immunity</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulins</subject><subject>immunology</subject><subject>Infant</subject><subject>inflammation</subject><subject>Inflammatory diseases</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Miscellaneous hereditary metabolic disorders</subject><subject>Norway</subject><subject>Norway - epidemiology</subject><subject>nutrient intake</subject><subject>Nutrition and Dietetics</subject><subject>Nutritional Status</subject><subject>Näringslära</subject><subject>original-article</subject><subject>patients</subject><subject>Pediatrics</subject><subject>Pediatrik</subject><subject>Preschool</subject><subject>Properties</subject><subject>Public Health</subject><subject>Regression Analysis</subject><subject>respiratory tract diseases</subject><subject>Scandinavian Cystic Fibrosis Nutritional Study</subject><subject>Sweden</subject><subject>Sweden - epidemiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>vitamin supplements</subject><subject>Young Adult</subject><issn>0954-3007</issn><issn>1476-5640</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9k01v1DAQhiMEoqVw5ApRER8HtjhxPpxj1dJSqYJDKVfLdiapi2MvdrzV_nsm3aXboraKnDgzz7we2zNJ8jojexmh7AtcKruXk-m3KZ4k21lRV7OyKsjTZJs0ZTGjhNRbyYsQLglBZ50_T7ZywsoGHdvJ8sQuwAdIPRgxamdTCeMVgE0XehSDtulhKmybBvBxSEc3CpPqYYjW9cbJaBA4TvE1XkB6ppDUViy0sOnBMoxapUdaehd0SL_H0etpARQ4G2O7fJk864QJ8Gr93UnOj77-PPg2O_1xfHKwfzpTjOTjTMqMCFVAKVtGWJ01sqmhrGpGBVApc0BTRTIJbavyEihBqsJJW3dQK1B0J5mtdMMVzKPkc68H4ZfcCc3Xpt84A14WjBUM-dMHeRPnOCSOKUCWVYN5lbyWpOFFRTuO2REuRU1Vx9pGZvDo8j3Koam_VssKmmc58p8f5A_1r33ufM9jRLyp8ynbjyt87t2fCGHkgw4KjBEWXAyc5XlNGmSR_PQomZGGFnVJKoLo7n_opYseb-5ajzKsogl6t4J6YYBr27nRCzVp8v28qDKstqrabP8O1YMFL4yz0Gk03-H37uHxaWHQ6t6AD7cCLkCY8SI4E6dSC_dmorAgg4fu5mgzwqdW4lMr8amVOLYS8m_WhxDlAO0N_a93EHi_BkRQwnReWKXDhqMMC7O8taWALtuD35zmQyu_XQV0wnHRexQ9P0MvJVmTY-lX9C9Q7T5M</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Pincikova, T</creator><creator>Nilsson, K</creator><creator>Moen, I.E</creator><creator>Karpati, F</creator><creator>Fluge, G</creator><creator>Hollsing, A</creator><creator>Knudsen, P.K</creator><creator>Lindblad, A</creator><creator>Mared, L</creator><creator>Pressler, T</creator><creator>Hjelte, L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>F1U</scope><scope>D95</scope></search><sort><creationdate>20110101</creationdate><title>Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study</title><author>Pincikova, T ; Nilsson, K ; Moen, I.E ; Karpati, F ; Fluge, G ; Hollsing, A ; Knudsen, P.K ; Lindblad, A ; Mared, L ; Pressler, T ; Hjelte, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c802t-bb10ac4e5bd808719b97e56783ae3bb2e719601beddc25e30808625ed7fe7cec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>25-hydroxycholecalciferol</topic><topic>631/250</topic><topic>692/699/1785</topic><topic>692/700/459/1994</topic><topic>administration & dosage</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alfacalcidol</topic><topic>analogs & derivatives</topic><topic>Antibiotics</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Calcifediol</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Nutrition</topic><topic>Colonization</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Cystic Fibrosis</topic><topic>Cystic Fibrosis - blood</topic><topic>Cystic Fibrosis - immunology</topic><topic>Cystic Fibrosis - metabolism</topic><topic>Denmark</topic><topic>Denmark - epidemiology</topic><topic>Dietary Supplements</topic><topic>disease severity</topic><topic>Epidemiology</topic><topic>Ergocalciferols</topic><topic>Ergocalciferols - administration & dosage</topic><topic>Ergocalciferols - blood</topic><topic>Errors of metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food</topic><topic>forced expiratory flow rates</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health Sciences</topic><topic>human diseases</topic><topic>human nutrition</topic><topic>Humans</topic><topic>Hälsovetenskap</topic><topic>Immune system</topic><topic>immunity</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulins</topic><topic>immunology</topic><topic>Infant</topic><topic>inflammation</topic><topic>Inflammatory diseases</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>metabolism</topic><topic>Middle Aged</topic><topic>Miscellaneous hereditary metabolic disorders</topic><topic>Norway</topic><topic>Norway - epidemiology</topic><topic>nutrient intake</topic><topic>Nutrition and Dietetics</topic><topic>Nutritional Status</topic><topic>Näringslära</topic><topic>original-article</topic><topic>patients</topic><topic>Pediatrics</topic><topic>Pediatrik</topic><topic>Preschool</topic><topic>Properties</topic><topic>Public Health</topic><topic>Regression Analysis</topic><topic>respiratory tract diseases</topic><topic>Scandinavian Cystic Fibrosis Nutritional Study</topic><topic>Sweden</topic><topic>Sweden - epidemiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>vitamin supplements</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pincikova, T</creatorcontrib><creatorcontrib>Nilsson, K</creatorcontrib><creatorcontrib>Moen, I.E</creatorcontrib><creatorcontrib>Karpati, F</creatorcontrib><creatorcontrib>Fluge, G</creatorcontrib><creatorcontrib>Hollsing, A</creatorcontrib><creatorcontrib>Knudsen, P.K</creatorcontrib><creatorcontrib>Lindblad, A</creatorcontrib><creatorcontrib>Mared, L</creatorcontrib><creatorcontrib>Pressler, T</creatorcontrib><creatorcontrib>Hjelte, L</creatorcontrib><creatorcontrib>Scandinavian Cystic Fibrosis Study Consortium</creatorcontrib><creatorcontrib>for the Scandinavian Cystic Fibrosis Study Consortium (SCFSC)</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Lunds universitet</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pincikova, T</au><au>Nilsson, K</au><au>Moen, I.E</au><au>Karpati, F</au><au>Fluge, G</au><au>Hollsing, A</au><au>Knudsen, P.K</au><au>Lindblad, A</au><au>Mared, L</au><au>Pressler, T</au><au>Hjelte, L</au><aucorp>Scandinavian Cystic Fibrosis Study Consortium</aucorp><aucorp>for the Scandinavian Cystic Fibrosis Study Consortium (SCFSC)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>65</volume><issue>1</issue><spage>102</spage><epage>109</epage><pages>102-109</pages><issn>0954-3007</issn><issn>1476-5640</issn><eissn>1476-5640</eissn><abstract>Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53–65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1λs (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and body mass index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R 2=0.376; beta=−0.02; P<0.001), supplemented vitamin D intake per kg bodyweight (adjusted R 2=0.375; beta=−0.82; P<0.001) and total vitamin D intake per kg bodyweight (adjusted R 2=0.398; beta=−0.60; P=0.002). Serum 25OHD was positively associated with FEV1 (adjusted R 2=0.308; beta=0.0007; P=0.025). Conclusions: Increasing vitamin D intake may positively modulate inflammation in CF. This study supports the proposed role of vitamin D in the immune system during infection and substantiates prospective studies.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20859300</pmid><doi>10.1038/ejcn.2010.194</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2011-01, Vol.65 (1), p.102-109 |
| issn | 0954-3007 1476-5640 1476-5640 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_548848 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 25-hydroxycholecalciferol 631/250 692/699/1785 692/700/459/1994 administration & dosage Adolescent Adult Aged Alfacalcidol analogs & derivatives Antibiotics Biological and medical sciences blood Calcifediol Care and treatment Child Child, Preschool Clinical Nutrition Colonization Correlation analysis Cross-Sectional Studies Cystic Fibrosis Cystic Fibrosis - blood Cystic Fibrosis - immunology Cystic Fibrosis - metabolism Denmark Denmark - epidemiology Dietary Supplements disease severity Epidemiology Ergocalciferols Ergocalciferols - administration & dosage Ergocalciferols - blood Errors of metabolism Feeding. Feeding behavior Female Food forced expiratory flow rates Fundamental and applied biological sciences. Psychology Health Sciences human diseases human nutrition Humans Hälsovetenskap Immune system immunity Immunoglobulin G Immunoglobulin G - blood Immunoglobulins immunology Infant inflammation Inflammatory diseases Internal Medicine Male Medical and Health Sciences Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicine & Public Health Metabolic Diseases metabolism Middle Aged Miscellaneous hereditary metabolic disorders Norway Norway - epidemiology nutrient intake Nutrition and Dietetics Nutritional Status Näringslära original-article patients Pediatrics Pediatrik Preschool Properties Public Health Regression Analysis respiratory tract diseases Scandinavian Cystic Fibrosis Nutritional Study Sweden Sweden - epidemiology Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood vitamin supplements Young Adult |
| title | Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study |
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