Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area
Background The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plastic...
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| creator | Kähler, Anna K Djurovic, Srdjan Rimol, Lars M Brown, Andrew Anand Athanasiu, Lavinia Jönsson, Erik G Hansen, Thomas Gústafsson, Ómar Hall, Håkan Giegling, Ina Muglia, Pierandrea Cichon, Sven Rietschel, Marcella Pietiläinen, Olli P.H Peltonen, Leena Bramon, Elvira Collier, David Clair, David St Sigurdsson, Engilbert Petursson, Hannes Rujescu, Dan Melle, Ingrid Werge, Thomas Steen, Vidar M Dale, Anders M Matthews, Russell T Agartz, Ingrid Andreassen, Ole A |
| description | Background The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods Ten genes of importance for HNK-1 biosynthesis ( B3GAT1 , B3GAT2 , and CHST10 ) or for the formation of perineuronal nets ( TNR , BCAN , NCAN , HAPLN1 , HAPLN2 , HAPLN3 , and HAPLN4 ) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of β-1,3-glucuronyltransferase 2 ( B3GAT2 ), were nominally associated with SCZ (.004 ≤ Pempirical ≤ .05). The rs2460691 was significantly associated in the comparison sample and in the meta-analysis after correction for all 121 SNP/haplotype tests ( Praw = 1 × 10−4 ; Pcorrected = .018). Increased dosage of the rs2460691 SCZ risk allele was associated with decreased cortical area ( p = .002) but not thickness or hippocampal volume. A second SNP ( r2 = .24 with rs10945275), which conferred the highest SCZ risk effect in the Norwegian subset, was also associated with cortical area. Conclusions The present results suggest that effects on biosynthesis of the neuronal epitope HNK-1, through common B3GAT2 variation, could increase the risk of SCZ, possibly by decreasing cortical area. |
| doi_str_mv | 10.1016/j.biopsych.2010.07.035 |
| format | Article |
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Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods Ten genes of importance for HNK-1 biosynthesis ( B3GAT1 , B3GAT2 , and CHST10 ) or for the formation of perineuronal nets ( TNR , BCAN , NCAN , HAPLN1 , HAPLN2 , HAPLN3 , and HAPLN4 ) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of β-1,3-glucuronyltransferase 2 ( B3GAT2 ), were nominally associated with SCZ (.004 ≤ Pempirical ≤ .05). The rs2460691 was significantly associated in the comparison sample and in the meta-analysis after correction for all 121 SNP/haplotype tests ( Praw = 1 × 10−4 ; Pcorrected = .018). Increased dosage of the rs2460691 SCZ risk allele was associated with decreased cortical area ( p = .002) but not thickness or hippocampal volume. A second SNP ( r2 = .24 with rs10945275), which conferred the highest SCZ risk effect in the Norwegian subset, was also associated with cortical area. Conclusions The present results suggest that effects on biosynthesis of the neuronal epitope HNK-1, through common B3GAT2 variation, could increase the risk of SCZ, possibly by decreasing cortical area.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2010.07.035</identifier><identifier>PMID: 20950796</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Alleles ; Association study ; Atrophy - pathology ; B3GAT1 ; Biological and medical sciences ; Case-Control Studies ; CD57 Antigens - genetics ; Cerebral Cortex - pathology ; Extracellular Matrix Proteins - genetics ; Genetic Predisposition to Disease - genetics ; Genome-Wide Association Study - methods ; Genotype ; GlcAT-P ; GlcAT-S ; Glucuronosyltransferase - genetics ; Hippocampus - pathology ; Humans ; Linkage Disequilibrium - genetics ; Medical sciences ; MRI ; Nerve Tissue Proteins - genetics ; Neurons - cytology ; Polymorphism, Single Nucleotide ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; psychosis ; Schizophrenia ; Signal Transduction - genetics</subject><ispartof>Biological psychiatry (1969), 2011, Vol.69 (1), p.90-96</ispartof><rights>Society of Biological Psychiatry</rights><rights>2011 Society of Biological Psychiatry</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-537439b61a5cc2e6e6feebb17a08782b9271ff13151693d1db2e6b5d1431e67a3</citedby><cites>FETCH-LOGICAL-c490t-537439b61a5cc2e6e6feebb17a08782b9271ff13151693d1db2e6b5d1431e67a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322310008553$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,4010,27900,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25376769$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20950796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:121800366$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kähler, Anna K</creatorcontrib><creatorcontrib>Djurovic, Srdjan</creatorcontrib><creatorcontrib>Rimol, Lars M</creatorcontrib><creatorcontrib>Brown, Andrew Anand</creatorcontrib><creatorcontrib>Athanasiu, Lavinia</creatorcontrib><creatorcontrib>Jönsson, Erik G</creatorcontrib><creatorcontrib>Hansen, Thomas</creatorcontrib><creatorcontrib>Gústafsson, Ómar</creatorcontrib><creatorcontrib>Hall, Håkan</creatorcontrib><creatorcontrib>Giegling, Ina</creatorcontrib><creatorcontrib>Muglia, Pierandrea</creatorcontrib><creatorcontrib>Cichon, Sven</creatorcontrib><creatorcontrib>Rietschel, Marcella</creatorcontrib><creatorcontrib>Pietiläinen, Olli P.H</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><creatorcontrib>Bramon, Elvira</creatorcontrib><creatorcontrib>Collier, David</creatorcontrib><creatorcontrib>Clair, David St</creatorcontrib><creatorcontrib>Sigurdsson, Engilbert</creatorcontrib><creatorcontrib>Petursson, Hannes</creatorcontrib><creatorcontrib>Rujescu, Dan</creatorcontrib><creatorcontrib>Melle, Ingrid</creatorcontrib><creatorcontrib>Werge, Thomas</creatorcontrib><creatorcontrib>Steen, Vidar M</creatorcontrib><creatorcontrib>Dale, Anders M</creatorcontrib><creatorcontrib>Matthews, Russell T</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><creatorcontrib>Andreassen, Ole A</creatorcontrib><title>Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods Ten genes of importance for HNK-1 biosynthesis ( B3GAT1 , B3GAT2 , and CHST10 ) or for the formation of perineuronal nets ( TNR , BCAN , NCAN , HAPLN1 , HAPLN2 , HAPLN3 , and HAPLN4 ) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of β-1,3-glucuronyltransferase 2 ( B3GAT2 ), were nominally associated with SCZ (.004 ≤ Pempirical ≤ .05). The rs2460691 was significantly associated in the comparison sample and in the meta-analysis after correction for all 121 SNP/haplotype tests ( Praw = 1 × 10−4 ; Pcorrected = .018). Increased dosage of the rs2460691 SCZ risk allele was associated with decreased cortical area ( p = .002) but not thickness or hippocampal volume. A second SNP ( r2 = .24 with rs10945275), which conferred the highest SCZ risk effect in the Norwegian subset, was also associated with cortical area. Conclusions The present results suggest that effects on biosynthesis of the neuronal epitope HNK-1, through common B3GAT2 variation, could increase the risk of SCZ, possibly by decreasing cortical area.</description><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Association study</subject><subject>Atrophy - pathology</subject><subject>B3GAT1</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CD57 Antigens - genetics</subject><subject>Cerebral Cortex - pathology</subject><subject>Extracellular Matrix Proteins - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genome-Wide Association Study - methods</subject><subject>Genotype</subject><subject>GlcAT-P</subject><subject>GlcAT-S</subject><subject>Glucuronosyltransferase - genetics</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Medical sciences</subject><subject>MRI</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Neurons - cytology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>psychosis</subject><subject>Schizophrenia</subject><subject>Signal Transduction - genetics</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhi0EYpfCX1j5gjil-COfHBClQHfFalnR5Ww5zkRxm8bFk1CFv8UfxKHdReLCyePRM6_H8w4hF5zNOePp6828tG6Po2nmgoUky-ZMJo_IOc8zGYmYicfknDGWRlIIeUaeIW7CNROCPyVnghUJy4r0nPxa6q6yle6BrqADuuh0O6JF6mraN0Avh53u6I3uB69b-tm2LfiI06X2pWvGyk-Ft7pvDnqkQYnegrcdDN4FHXoDPVLb0bVp7E-3bzx0Vr-h7-VqcSfoFdIFojM2aFT0YPuGfrAIGoF-tbj9I7d0vrcmSK0HX2sT-vOgn5MntW4RXpzOGfn26ePd8jK6_rK6Wi6uIxMXrI8SmcWyKFOuE2MEpJDWAGXJM83yLBdlITJe11zyhKeFrHhVBqhMKh5LDmmm5YxER108wH4o1d7bnfajctqqU2obIlBJnMeMBf7Vkd97930A7NXOooG21R24AVUuOC9invJApkfSeIfooX7Q5kxN_qqNuvdXTf4qlqngbyi8OD0xlDuoHsruDQ3AyxOgMcyt9rozFv9yYShpFr47I--OHIQB_rDgFRoLnYHKejC9qpz9fy9v_5Ewre0mt7YwAm7c4MMSoOIKhWJqPW3jtIw8BHmSSPkbzzzdYg</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Kähler, Anna K</creator><creator>Djurovic, Srdjan</creator><creator>Rimol, Lars M</creator><creator>Brown, Andrew Anand</creator><creator>Athanasiu, Lavinia</creator><creator>Jönsson, Erik G</creator><creator>Hansen, Thomas</creator><creator>Gústafsson, Ómar</creator><creator>Hall, Håkan</creator><creator>Giegling, Ina</creator><creator>Muglia, Pierandrea</creator><creator>Cichon, Sven</creator><creator>Rietschel, Marcella</creator><creator>Pietiläinen, Olli P.H</creator><creator>Peltonen, Leena</creator><creator>Bramon, Elvira</creator><creator>Collier, David</creator><creator>Clair, David St</creator><creator>Sigurdsson, Engilbert</creator><creator>Petursson, Hannes</creator><creator>Rujescu, Dan</creator><creator>Melle, Ingrid</creator><creator>Werge, Thomas</creator><creator>Steen, Vidar M</creator><creator>Dale, Anders M</creator><creator>Matthews, Russell T</creator><creator>Agartz, Ingrid</creator><creator>Andreassen, Ole A</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>2011</creationdate><title>Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area</title><author>Kähler, Anna K ; Djurovic, Srdjan ; Rimol, Lars M ; Brown, Andrew Anand ; Athanasiu, Lavinia ; Jönsson, Erik G ; Hansen, Thomas ; Gústafsson, Ómar ; Hall, Håkan ; Giegling, Ina ; Muglia, Pierandrea ; Cichon, Sven ; Rietschel, Marcella ; Pietiläinen, Olli P.H ; Peltonen, Leena ; Bramon, Elvira ; Collier, David ; Clair, David St ; Sigurdsson, Engilbert ; Petursson, Hannes ; Rujescu, Dan ; Melle, Ingrid ; Werge, Thomas ; Steen, Vidar M ; Dale, Anders M ; Matthews, Russell T ; Agartz, Ingrid ; Andreassen, Ole A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-537439b61a5cc2e6e6feebb17a08782b9271ff13151693d1db2e6b5d1431e67a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Association study</topic><topic>Atrophy - pathology</topic><topic>B3GAT1</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CD57 Antigens - genetics</topic><topic>Cerebral Cortex - pathology</topic><topic>Extracellular Matrix Proteins - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genome-Wide Association Study - methods</topic><topic>Genotype</topic><topic>GlcAT-P</topic><topic>GlcAT-S</topic><topic>Glucuronosyltransferase - genetics</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Linkage Disequilibrium - genetics</topic><topic>Medical sciences</topic><topic>MRI</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Neurons - cytology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>psychosis</topic><topic>Schizophrenia</topic><topic>Signal Transduction - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kähler, Anna K</creatorcontrib><creatorcontrib>Djurovic, Srdjan</creatorcontrib><creatorcontrib>Rimol, Lars M</creatorcontrib><creatorcontrib>Brown, Andrew Anand</creatorcontrib><creatorcontrib>Athanasiu, Lavinia</creatorcontrib><creatorcontrib>Jönsson, Erik G</creatorcontrib><creatorcontrib>Hansen, Thomas</creatorcontrib><creatorcontrib>Gústafsson, Ómar</creatorcontrib><creatorcontrib>Hall, Håkan</creatorcontrib><creatorcontrib>Giegling, Ina</creatorcontrib><creatorcontrib>Muglia, Pierandrea</creatorcontrib><creatorcontrib>Cichon, Sven</creatorcontrib><creatorcontrib>Rietschel, Marcella</creatorcontrib><creatorcontrib>Pietiläinen, Olli P.H</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><creatorcontrib>Bramon, Elvira</creatorcontrib><creatorcontrib>Collier, David</creatorcontrib><creatorcontrib>Clair, David St</creatorcontrib><creatorcontrib>Sigurdsson, Engilbert</creatorcontrib><creatorcontrib>Petursson, Hannes</creatorcontrib><creatorcontrib>Rujescu, Dan</creatorcontrib><creatorcontrib>Melle, Ingrid</creatorcontrib><creatorcontrib>Werge, Thomas</creatorcontrib><creatorcontrib>Steen, Vidar M</creatorcontrib><creatorcontrib>Dale, Anders M</creatorcontrib><creatorcontrib>Matthews, Russell T</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><creatorcontrib>Andreassen, Ole A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kähler, Anna K</au><au>Djurovic, Srdjan</au><au>Rimol, Lars M</au><au>Brown, Andrew Anand</au><au>Athanasiu, Lavinia</au><au>Jönsson, Erik G</au><au>Hansen, Thomas</au><au>Gústafsson, Ómar</au><au>Hall, Håkan</au><au>Giegling, Ina</au><au>Muglia, Pierandrea</au><au>Cichon, Sven</au><au>Rietschel, Marcella</au><au>Pietiläinen, Olli P.H</au><au>Peltonen, Leena</au><au>Bramon, Elvira</au><au>Collier, David</au><au>Clair, David St</au><au>Sigurdsson, Engilbert</au><au>Petursson, Hannes</au><au>Rujescu, Dan</au><au>Melle, Ingrid</au><au>Werge, Thomas</au><au>Steen, Vidar M</au><au>Dale, Anders M</au><au>Matthews, Russell T</au><au>Agartz, Ingrid</au><au>Andreassen, Ole A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2011</date><risdate>2011</risdate><volume>69</volume><issue>1</issue><spage>90</spage><epage>96</epage><pages>90-96</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods Ten genes of importance for HNK-1 biosynthesis ( B3GAT1 , B3GAT2 , and CHST10 ) or for the formation of perineuronal nets ( TNR , BCAN , NCAN , HAPLN1 , HAPLN2 , HAPLN3 , and HAPLN4 ) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of β-1,3-glucuronyltransferase 2 ( B3GAT2 ), were nominally associated with SCZ (.004 ≤ Pempirical ≤ .05). The rs2460691 was significantly associated in the comparison sample and in the meta-analysis after correction for all 121 SNP/haplotype tests ( Praw = 1 × 10−4 ; Pcorrected = .018). Increased dosage of the rs2460691 SCZ risk allele was associated with decreased cortical area ( p = .002) but not thickness or hippocampal volume. A second SNP ( r2 = .24 with rs10945275), which conferred the highest SCZ risk effect in the Norwegian subset, was also associated with cortical area. Conclusions The present results suggest that effects on biosynthesis of the neuronal epitope HNK-1, through common B3GAT2 variation, could increase the risk of SCZ, possibly by decreasing cortical area.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20950796</pmid><doi>10.1016/j.biopsych.2010.07.035</doi><tpages>7</tpages></addata></record> |
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| recordid | cdi_swepub_primary_oai_swepub_ki_se_548400 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult and adolescent clinical studies Alleles Association study Atrophy - pathology B3GAT1 Biological and medical sciences Case-Control Studies CD57 Antigens - genetics Cerebral Cortex - pathology Extracellular Matrix Proteins - genetics Genetic Predisposition to Disease - genetics Genome-Wide Association Study - methods Genotype GlcAT-P GlcAT-S Glucuronosyltransferase - genetics Hippocampus - pathology Humans Linkage Disequilibrium - genetics Medical sciences MRI Nerve Tissue Proteins - genetics Neurons - cytology Polymorphism, Single Nucleotide Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses psychosis Schizophrenia Signal Transduction - genetics |
| title | Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T11%3A48%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Candidate%20Gene%20Analysis%20of%20the%20Human%20Natural%20Killer-1%20Carbohydrate%20Pathway%20and%20Perineuronal%20Nets%20in%20Schizophrenia:%20B3GAT2%20Is%20Associated%20with%20Disease%20Risk%20and%20Cortical%20Surface%20Area&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=K%C3%A4hler,%20Anna%20K&rft.date=2011&rft.volume=69&rft.issue=1&rft.spage=90&rft.epage=96&rft.pages=90-96&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/j.biopsych.2010.07.035&rft_dat=%3Cproquest_swepu%3E821194161%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=821194161&rft_id=info:pmid/20950796&rft_els_id=S0006322310008553&rfr_iscdi=true |