A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

Richard Trembath, Peter Donnelly and colleagues report a genome-wide association study identifying six new psoriasis susceptibility loci. They also identify a statistical interaction between HLA-C and ERAP1 in psoriasis susceptibility. To identify new susceptibility loci for psoriasis, we undertook...

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Veröffentlicht in:	Nature genetics 2010-11, Vol.42 (11), p.985-990
Hauptverfasser:	Strange, Amy, Capon, Francesca, Spencer, Chris C A, Knight, Jo, Weale, Michael E, Allen, Michael H, Barton, Anne, Band, Gavin, Bellenguez, Céline, Bergboer, Judith G M, Blackwell, Jenefer M, Bramon, Elvira, Bumpstead, Suzannah J, Casas, Juan P, Cork, Michael J, Corvin, Aiden, Deloukas, Panos, Dilthey, Alexander, Duncanson, Audrey, Edkins, Sarah, Estivill, Xavier, Fitzgerald, Oliver, Freeman, Colin, Giardina, Emiliano, Gray, Emma, Hofer, Angelika, Hüffmeier, Ulrike, Hunt, Sarah E, Irvine, Alan D, Jankowski, Janusz, Kirby, Brian, Langford, Cordelia, Lascorz, Jesús, Leman, Joyce, Leslie, Stephen, Mallbris, Lotus, Markus, Hugh S, Mathew, Christopher G, McLean, W H Irwin, McManus, Ross, Mössner, Rotraut, Moutsianas, Loukas, Naluai, Asa T, Nestle, Frank O, Novelli, Giuseppe, Onoufriadis, Alexandros, Palmer, Colin N A, Perricone, Carlo, Pirinen, Matti, Plomin, Robert, Potter, Simon C, Pujol, Ramon M, Rautanen, Anna, Riveira-Munoz, Eva, Ryan, Anthony W, Salmhofer, Wolfgang, Samuelsson, Lena, Sawcer, Stephen J, Schalkwijk, Joost, Smith, Catherine H, Ståhle, Mona, Su, Zhan, Tazi-Ahnini, Rachid, Traupe, Heiko, Viswanathan, Ananth C, Warren, Richard B, Weger, Wolfgang, Wolk, Katarina, Wood, Nicholas, Worthington, Jane, Young, Helen S, Zeeuwen, Patrick L J M, Hayday, Adrian, Burden, A David, Griffiths, Christopher E M, Kere, Juha, Reis, André, McVean, Gilean, Evans, David M, Brown, Matthew A, Barker, Jonathan N, Peltonen, Leena, Donnelly, Peter, Trembath, Richard C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205/2138 631/208/2490 631/250/249/2510/1758 Agriculture Aminopeptidases - genetics Animal Genetics and Genomics autoimmunity Biological and medical sciences Biomedical and Life Sciences Biomedical research Biomedicine Cancer Research Care and treatment Chromosome Mapping Chromosomes, Human - genetics Chromosomes, Human, X - genetics complex Deoxyribonucleic acid Dermatology Disease susceptibility diseases DNA Europe family Fundamental and applied biological sciences. Psychology gene Gene Function Genetic aspects Genetic Predisposition to Disease Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Health aspects Health services Histocompatibility antigens HLA histocompatibility antigens HLA-C Antigens - genetics Human Genetics Humans letter Major Histocompatibility Complex - genetics Medical Genetics and Genomics Medical research Medical sciences Medicinsk genetik och genomik Minor Histocompatibility Antigens pathways Polymorphism, Single Nucleotide Principal components analysis Psoriasis Psoriasis - genetics Psoriasis. Parapsoriasis. Lichen Quality control Reference Values responses Risk Assessment scan Skin diseases statistical-method variants
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