A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conduc...
Gespeichert in:
Veröffentlicht in: | International journal of cancer 2011-10, Vol.129 (7), p.1708-1717 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1717 |
---|---|
container_issue | 7 |
container_start_page | 1708 |
container_title | International journal of cancer |
container_volume | 129 |
creator | Genkinger, Jeanine M. Spiegelman, Donna Anderson, Kristin E. Bernstein, Leslie van den Brandt, Piet A. Calle, Eugenia E. English, Dallas R. Folsom, Aaron R. Freudenheim, Jo L. Fuchs, Charles S. Giles, Graham G. Giovannucci, Edward Horn‐Ross, Pamela L. Larsson, Susanna C. Leitzmann, Michael Männistö, Satu Marshall, James R. Miller, Anthony B. Patel, Alpa V. Rohan, Thomas E. Stolzenberg‐Solomon, Rachael Z. Verhage, Bas AJ Virtamo, Jarmo Willcox, Bradley J. Wolk, Alicja Ziegler, Regina G. Smith‐Warner, Stephanie A. |
description | Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m2) and not obese at baseline (BMI < 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer. |
doi_str_mv | 10.1002/ijc.25794 |
format | Article |
fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_547616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>879679603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6184-dbe2a2128b9e367bd0d3924e95beecc417582c617b38de6b35dc3efc19b73c1d3</originalsourceid><addsrcrecordid>eNp9kk9v1DAQxSMEotvCgS-AckGARFqP7cTxBWm15U9RJS7AhYPl2JOu22yc2gnVfnu8zVLooUiWbL35eZ6teVn2AsgxEEJP3KU5pqWQ_FG2ACJFQSiUj7NFqpFCAKsOssMYLwkBKAl_mh1QAFISKhfZz2U-eN-hzXWvu210MfdtDjw3fu3DmMdxsg5vRd2P6-AHv8ExOJO32ow-xCTbfNC9CajHJJt0xJAHF6-eZU9a3UV8vt-Psu8fP3xbfS7Ov346Wy3PC1NBzQvbINUUaN1IZJVoLLFMUo6ybBCN4SDKmiZUNKy2WDWstIZha0A2ghmw7Cgr5r7xBoepUUNwGx22ymun9tJVOqEquaigSvy7B_lT92OpfLhQ06Q4paRmCX8_44ndoDXYj0F3927dr_RurS78L8WIYFDu_F7vGwR_PWEc1cZFg12ne_RTVLWQVVpkZ_XmvyQQEFJAml5C386oCT7GgO3dg4CoXSpUSoW6TUViX_77gzvyTwwS8GoP6Gh014Y0RBf_cpyXkjBI3MnM3bgOtw87qrMvq9n6N0emz_g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1017971110</pqid></control><display><type>article</type><title>A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SWEPUB Freely available online</source><creator>Genkinger, Jeanine M. ; Spiegelman, Donna ; Anderson, Kristin E. ; Bernstein, Leslie ; van den Brandt, Piet A. ; Calle, Eugenia E. ; English, Dallas R. ; Folsom, Aaron R. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giles, Graham G. ; Giovannucci, Edward ; Horn‐Ross, Pamela L. ; Larsson, Susanna C. ; Leitzmann, Michael ; Männistö, Satu ; Marshall, James R. ; Miller, Anthony B. ; Patel, Alpa V. ; Rohan, Thomas E. ; Stolzenberg‐Solomon, Rachael Z. ; Verhage, Bas AJ ; Virtamo, Jarmo ; Willcox, Bradley J. ; Wolk, Alicja ; Ziegler, Regina G. ; Smith‐Warner, Stephanie A.</creator><creatorcontrib>Genkinger, Jeanine M. ; Spiegelman, Donna ; Anderson, Kristin E. ; Bernstein, Leslie ; van den Brandt, Piet A. ; Calle, Eugenia E. ; English, Dallas R. ; Folsom, Aaron R. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giles, Graham G. ; Giovannucci, Edward ; Horn‐Ross, Pamela L. ; Larsson, Susanna C. ; Leitzmann, Michael ; Männistö, Satu ; Marshall, James R. ; Miller, Anthony B. ; Patel, Alpa V. ; Rohan, Thomas E. ; Stolzenberg‐Solomon, Rachael Z. ; Verhage, Bas AJ ; Virtamo, Jarmo ; Willcox, Bradley J. ; Wolk, Alicja ; Ziegler, Regina G. ; Smith‐Warner, Stephanie A.</creatorcontrib><description>Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m2) and not obese at baseline (BMI < 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.</description><identifier>ISSN: 0020-7136</identifier><identifier>ISSN: 1097-0215</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.25794</identifier><identifier>PMID: 21105029</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Anthropometry ; Biological and medical sciences ; Body Height ; Body mass ; Body Mass Index ; Body weight ; Cancer ; deceased ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Morbidity ; Mortality ; Obesity ; pancreatic cancer ; Pancreatic Neoplasms - epidemiology ; pooled analysis ; Risk Factors ; Tumors ; Waist-Hip Ratio</subject><ispartof>International journal of cancer, 2011-10, Vol.129 (7), p.1708-1717</ispartof><rights>Copyright © 2010 UICC</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 UICC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6184-dbe2a2128b9e367bd0d3924e95beecc417582c617b38de6b35dc3efc19b73c1d3</citedby><cites>FETCH-LOGICAL-c6184-dbe2a2128b9e367bd0d3924e95beecc417582c617b38de6b35dc3efc19b73c1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.25794$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.25794$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24459031$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21105029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422083$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122990903$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Genkinger, Jeanine M.</creatorcontrib><creatorcontrib>Spiegelman, Donna</creatorcontrib><creatorcontrib>Anderson, Kristin E.</creatorcontrib><creatorcontrib>Bernstein, Leslie</creatorcontrib><creatorcontrib>van den Brandt, Piet A.</creatorcontrib><creatorcontrib>Calle, Eugenia E.</creatorcontrib><creatorcontrib>English, Dallas R.</creatorcontrib><creatorcontrib>Folsom, Aaron R.</creatorcontrib><creatorcontrib>Freudenheim, Jo L.</creatorcontrib><creatorcontrib>Fuchs, Charles S.</creatorcontrib><creatorcontrib>Giles, Graham G.</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><creatorcontrib>Horn‐Ross, Pamela L.</creatorcontrib><creatorcontrib>Larsson, Susanna C.</creatorcontrib><creatorcontrib>Leitzmann, Michael</creatorcontrib><creatorcontrib>Männistö, Satu</creatorcontrib><creatorcontrib>Marshall, James R.</creatorcontrib><creatorcontrib>Miller, Anthony B.</creatorcontrib><creatorcontrib>Patel, Alpa V.</creatorcontrib><creatorcontrib>Rohan, Thomas E.</creatorcontrib><creatorcontrib>Stolzenberg‐Solomon, Rachael Z.</creatorcontrib><creatorcontrib>Verhage, Bas AJ</creatorcontrib><creatorcontrib>Virtamo, Jarmo</creatorcontrib><creatorcontrib>Willcox, Bradley J.</creatorcontrib><creatorcontrib>Wolk, Alicja</creatorcontrib><creatorcontrib>Ziegler, Regina G.</creatorcontrib><creatorcontrib>Smith‐Warner, Stephanie A.</creatorcontrib><title>A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m2) and not obese at baseline (BMI < 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Cancer</subject><subject>deceased</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Obesity</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>pooled analysis</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Waist-Hip Ratio</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kk9v1DAQxSMEotvCgS-AckGARFqP7cTxBWm15U9RJS7AhYPl2JOu22yc2gnVfnu8zVLooUiWbL35eZ6teVn2AsgxEEJP3KU5pqWQ_FG2ACJFQSiUj7NFqpFCAKsOssMYLwkBKAl_mh1QAFISKhfZz2U-eN-hzXWvu210MfdtDjw3fu3DmMdxsg5vRd2P6-AHv8ExOJO32ow-xCTbfNC9CajHJJt0xJAHF6-eZU9a3UV8vt-Psu8fP3xbfS7Ov346Wy3PC1NBzQvbINUUaN1IZJVoLLFMUo6ybBCN4SDKmiZUNKy2WDWstIZha0A2ghmw7Cgr5r7xBoepUUNwGx22ymun9tJVOqEquaigSvy7B_lT92OpfLhQ06Q4paRmCX8_44ndoDXYj0F3927dr_RurS78L8WIYFDu_F7vGwR_PWEc1cZFg12ne_RTVLWQVVpkZ_XmvyQQEFJAml5C386oCT7GgO3dg4CoXSpUSoW6TUViX_77gzvyTwwS8GoP6Gh014Y0RBf_cpyXkjBI3MnM3bgOtw87qrMvq9n6N0emz_g</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Genkinger, Jeanine M.</creator><creator>Spiegelman, Donna</creator><creator>Anderson, Kristin E.</creator><creator>Bernstein, Leslie</creator><creator>van den Brandt, Piet A.</creator><creator>Calle, Eugenia E.</creator><creator>English, Dallas R.</creator><creator>Folsom, Aaron R.</creator><creator>Freudenheim, Jo L.</creator><creator>Fuchs, Charles S.</creator><creator>Giles, Graham G.</creator><creator>Giovannucci, Edward</creator><creator>Horn‐Ross, Pamela L.</creator><creator>Larsson, Susanna C.</creator><creator>Leitzmann, Michael</creator><creator>Männistö, Satu</creator><creator>Marshall, James R.</creator><creator>Miller, Anthony B.</creator><creator>Patel, Alpa V.</creator><creator>Rohan, Thomas E.</creator><creator>Stolzenberg‐Solomon, Rachael Z.</creator><creator>Verhage, Bas AJ</creator><creator>Virtamo, Jarmo</creator><creator>Willcox, Bradley J.</creator><creator>Wolk, Alicja</creator><creator>Ziegler, Regina G.</creator><creator>Smith‐Warner, Stephanie A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20111001</creationdate><title>A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk</title><author>Genkinger, Jeanine M. ; Spiegelman, Donna ; Anderson, Kristin E. ; Bernstein, Leslie ; van den Brandt, Piet A. ; Calle, Eugenia E. ; English, Dallas R. ; Folsom, Aaron R. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giles, Graham G. ; Giovannucci, Edward ; Horn‐Ross, Pamela L. ; Larsson, Susanna C. ; Leitzmann, Michael ; Männistö, Satu ; Marshall, James R. ; Miller, Anthony B. ; Patel, Alpa V. ; Rohan, Thomas E. ; Stolzenberg‐Solomon, Rachael Z. ; Verhage, Bas AJ ; Virtamo, Jarmo ; Willcox, Bradley J. ; Wolk, Alicja ; Ziegler, Regina G. ; Smith‐Warner, Stephanie A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6184-dbe2a2128b9e367bd0d3924e95beecc417582c617b38de6b35dc3efc19b73c1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Body Height</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Cancer</topic><topic>deceased</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Obesity</topic><topic>pancreatic cancer</topic><topic>Pancreatic Neoplasms - epidemiology</topic><topic>pooled analysis</topic><topic>Risk Factors</topic><topic>Tumors</topic><topic>Waist-Hip Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Genkinger, Jeanine M.</creatorcontrib><creatorcontrib>Spiegelman, Donna</creatorcontrib><creatorcontrib>Anderson, Kristin E.</creatorcontrib><creatorcontrib>Bernstein, Leslie</creatorcontrib><creatorcontrib>van den Brandt, Piet A.</creatorcontrib><creatorcontrib>Calle, Eugenia E.</creatorcontrib><creatorcontrib>English, Dallas R.</creatorcontrib><creatorcontrib>Folsom, Aaron R.</creatorcontrib><creatorcontrib>Freudenheim, Jo L.</creatorcontrib><creatorcontrib>Fuchs, Charles S.</creatorcontrib><creatorcontrib>Giles, Graham G.</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><creatorcontrib>Horn‐Ross, Pamela L.</creatorcontrib><creatorcontrib>Larsson, Susanna C.</creatorcontrib><creatorcontrib>Leitzmann, Michael</creatorcontrib><creatorcontrib>Männistö, Satu</creatorcontrib><creatorcontrib>Marshall, James R.</creatorcontrib><creatorcontrib>Miller, Anthony B.</creatorcontrib><creatorcontrib>Patel, Alpa V.</creatorcontrib><creatorcontrib>Rohan, Thomas E.</creatorcontrib><creatorcontrib>Stolzenberg‐Solomon, Rachael Z.</creatorcontrib><creatorcontrib>Verhage, Bas AJ</creatorcontrib><creatorcontrib>Virtamo, Jarmo</creatorcontrib><creatorcontrib>Willcox, Bradley J.</creatorcontrib><creatorcontrib>Wolk, Alicja</creatorcontrib><creatorcontrib>Ziegler, Regina G.</creatorcontrib><creatorcontrib>Smith‐Warner, Stephanie A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Genkinger, Jeanine M.</au><au>Spiegelman, Donna</au><au>Anderson, Kristin E.</au><au>Bernstein, Leslie</au><au>van den Brandt, Piet A.</au><au>Calle, Eugenia E.</au><au>English, Dallas R.</au><au>Folsom, Aaron R.</au><au>Freudenheim, Jo L.</au><au>Fuchs, Charles S.</au><au>Giles, Graham G.</au><au>Giovannucci, Edward</au><au>Horn‐Ross, Pamela L.</au><au>Larsson, Susanna C.</au><au>Leitzmann, Michael</au><au>Männistö, Satu</au><au>Marshall, James R.</au><au>Miller, Anthony B.</au><au>Patel, Alpa V.</au><au>Rohan, Thomas E.</au><au>Stolzenberg‐Solomon, Rachael Z.</au><au>Verhage, Bas AJ</au><au>Virtamo, Jarmo</au><au>Willcox, Bradley J.</au><au>Wolk, Alicja</au><au>Ziegler, Regina G.</au><au>Smith‐Warner, Stephanie A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>129</volume><issue>7</issue><spage>1708</spage><epage>1717</epage><pages>1708-1717</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m2) and not obese at baseline (BMI < 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21105029</pmid><doi>10.1002/ijc.25794</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0020-7136 |
ispartof | International journal of cancer, 2011-10, Vol.129 (7), p.1708-1717 |
issn | 0020-7136 1097-0215 1097-0215 |
language | eng |
recordid | cdi_swepub_primary_oai_swepub_ki_se_547616 |
source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; SWEPUB Freely available online |
subjects | Adult Age Aged Aged, 80 and over Anthropometry Biological and medical sciences Body Height Body mass Body Mass Index Body weight Cancer deceased Female Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Morbidity Mortality Obesity pancreatic cancer Pancreatic Neoplasms - epidemiology pooled analysis Risk Factors Tumors Waist-Hip Ratio |
title | A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A50%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20pooled%20analysis%20of%2014%20cohort%20studies%20of%20anthropometric%20factors%20and%20pancreatic%20cancer%20risk&rft.jtitle=International%20journal%20of%20cancer&rft.au=Genkinger,%20Jeanine%20M.&rft.date=2011-10-01&rft.volume=129&rft.issue=7&rft.spage=1708&rft.epage=1717&rft.pages=1708-1717&rft.issn=0020-7136&rft.eissn=1097-0215&rft.coden=IJCNAW&rft_id=info:doi/10.1002/ijc.25794&rft_dat=%3Cproquest_swepu%3E879679603%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1017971110&rft_id=info:pmid/21105029&rfr_iscdi=true |