A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conduc...

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Veröffentlicht in:International journal of cancer 2011-10, Vol.129 (7), p.1708-1717
Hauptverfasser: Genkinger, Jeanine M., Spiegelman, Donna, Anderson, Kristin E., Bernstein, Leslie, van den Brandt, Piet A., Calle, Eugenia E., English, Dallas R., Folsom, Aaron R., Freudenheim, Jo L., Fuchs, Charles S., Giles, Graham G., Giovannucci, Edward, Horn‐Ross, Pamela L., Larsson, Susanna C., Leitzmann, Michael, Männistö, Satu, Marshall, James R., Miller, Anthony B., Patel, Alpa V., Rohan, Thomas E., Stolzenberg‐Solomon, Rachael Z., Verhage, Bas AJ, Virtamo, Jarmo, Willcox, Bradley J., Wolk, Alicja, Ziegler, Regina G., Smith‐Warner, Stephanie A.
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container_end_page 1717
container_issue 7
container_start_page 1708
container_title International journal of cancer
container_volume 129
creator Genkinger, Jeanine M.
Spiegelman, Donna
Anderson, Kristin E.
Bernstein, Leslie
van den Brandt, Piet A.
Calle, Eugenia E.
English, Dallas R.
Folsom, Aaron R.
Freudenheim, Jo L.
Fuchs, Charles S.
Giles, Graham G.
Giovannucci, Edward
Horn‐Ross, Pamela L.
Larsson, Susanna C.
Leitzmann, Michael
Männistö, Satu
Marshall, James R.
Miller, Anthony B.
Patel, Alpa V.
Rohan, Thomas E.
Stolzenberg‐Solomon, Rachael Z.
Verhage, Bas AJ
Virtamo, Jarmo
Willcox, Bradley J.
Wolk, Alicja
Ziegler, Regina G.
Smith‐Warner, Stephanie A.
description Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m2) and not obese at baseline (BMI < 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.
doi_str_mv 10.1002/ijc.25794
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Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI &lt; 25 kg/m2) and not obese at baseline (BMI &lt; 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. 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Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI &lt; 25 kg/m2) and not obese at baseline (BMI &lt; 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Cancer</subject><subject>deceased</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Obesity</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>pooled analysis</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Waist-Hip Ratio</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kk9v1DAQxSMEotvCgS-AckGARFqP7cTxBWm15U9RJS7AhYPl2JOu22yc2gnVfnu8zVLooUiWbL35eZ6teVn2AsgxEEJP3KU5pqWQ_FG2ACJFQSiUj7NFqpFCAKsOssMYLwkBKAl_mh1QAFISKhfZz2U-eN-hzXWvu210MfdtDjw3fu3DmMdxsg5vRd2P6-AHv8ExOJO32ow-xCTbfNC9CajHJJt0xJAHF6-eZU9a3UV8vt-Psu8fP3xbfS7Ov346Wy3PC1NBzQvbINUUaN1IZJVoLLFMUo6ybBCN4SDKmiZUNKy2WDWstIZha0A2ghmw7Cgr5r7xBoepUUNwGx22ymun9tJVOqEquaigSvy7B_lT92OpfLhQ06Q4paRmCX8_44ndoDXYj0F3927dr_RurS78L8WIYFDu_F7vGwR_PWEc1cZFg12ne_RTVLWQVVpkZ_XmvyQQEFJAml5C386oCT7GgO3dg4CoXSpUSoW6TUViX_77gzvyTwwS8GoP6Gh014Y0RBf_cpyXkjBI3MnM3bgOtw87qrMvq9n6N0emz_g</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Genkinger, Jeanine M.</creator><creator>Spiegelman, Donna</creator><creator>Anderson, Kristin E.</creator><creator>Bernstein, Leslie</creator><creator>van den Brandt, Piet A.</creator><creator>Calle, Eugenia E.</creator><creator>English, Dallas R.</creator><creator>Folsom, Aaron R.</creator><creator>Freudenheim, Jo L.</creator><creator>Fuchs, Charles S.</creator><creator>Giles, Graham G.</creator><creator>Giovannucci, Edward</creator><creator>Horn‐Ross, Pamela L.</creator><creator>Larsson, Susanna C.</creator><creator>Leitzmann, Michael</creator><creator>Männistö, Satu</creator><creator>Marshall, James R.</creator><creator>Miller, Anthony B.</creator><creator>Patel, Alpa V.</creator><creator>Rohan, Thomas E.</creator><creator>Stolzenberg‐Solomon, Rachael Z.</creator><creator>Verhage, Bas AJ</creator><creator>Virtamo, Jarmo</creator><creator>Willcox, Bradley J.</creator><creator>Wolk, Alicja</creator><creator>Ziegler, Regina G.</creator><creator>Smith‐Warner, Stephanie A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20111001</creationdate><title>A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk</title><author>Genkinger, Jeanine M. ; Spiegelman, Donna ; Anderson, Kristin E. ; Bernstein, Leslie ; van den Brandt, Piet A. ; Calle, Eugenia E. ; English, Dallas R. ; Folsom, Aaron R. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giles, Graham G. ; Giovannucci, Edward ; Horn‐Ross, Pamela L. ; Larsson, Susanna C. ; Leitzmann, Michael ; Männistö, Satu ; Marshall, James R. ; Miller, Anthony B. ; Patel, Alpa V. ; Rohan, Thomas E. ; Stolzenberg‐Solomon, Rachael Z. ; Verhage, Bas AJ ; Virtamo, Jarmo ; Willcox, Bradley J. ; Wolk, Alicja ; Ziegler, Regina G. ; Smith‐Warner, Stephanie A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6184-dbe2a2128b9e367bd0d3924e95beecc417582c617b38de6b35dc3efc19b73c1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Body Height</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Cancer</topic><topic>deceased</topic><topic>Female</topic><topic>Gastroenterology. 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Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow‐up. Study‐specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21–22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23–75%) among obese (BMI ≥ 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09–1.56 comparing BMI ≥ 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI &lt; 25 kg/m2) and not obese at baseline (BMI &lt; 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24–93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03–1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21105029</pmid><doi>10.1002/ijc.25794</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; SWEPUB Freely available online
subjects Adult
Age
Aged
Aged, 80 and over
Anthropometry
Biological and medical sciences
Body Height
Body mass
Body Mass Index
Body weight
Cancer
deceased
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Morbidity
Mortality
Obesity
pancreatic cancer
Pancreatic Neoplasms - epidemiology
pooled analysis
Risk Factors
Tumors
Waist-Hip Ratio
title A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
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