Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases

Platelet-derived growth factor (PDGF) plays a pivotal role in the pathobiology of pulmonary hypertension (PH) because it promotes pulmonary vascular remodeling. PH is frequently associated with pulmonary hypoxia. To investigate whether hypoxia alters PDGF β receptor (βPDGFR) signaling in the pulmona...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2011-04, Vol.183 (8), p.1092-1102
Hauptverfasser:	ten Freyhaus, Henrik, Dagnell, Markus, Leuchs, Maike, Vantler, Marius, Berghausen, Eva M, Caglayan, Evren, Weissmann, Norbert, Dahal, Bhola K, Schermuly, Ralph T, Ostman, Arne, Kappert, Kai, Rosenkranz, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Blood platelets Cell Proliferation Cells, Cultured Chemotaxis - physiology Down-Regulation - physiology Growth factors Humans Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Hypoxia Hypoxia - physiopathology Kinases Ligands Lung - blood supply Lungs Medical prognosis Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - physiopathology Phosphatase Phosphorylation Platelet-Derived Growth Factor - physiology Protein Tyrosine Phosphatases - physiology Proteins Pulmonary arteries Pulmonary Artery - physiopathology Pulmonary hypertension Receptor, Platelet-Derived Growth Factor beta - physiology Signal Transduction - physiology Smooth muscle
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