The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial

The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence in situ hybridization analyses—i...

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Veröffentlicht in:	Leukemia 2011-04, Vol.25 (4), p.622-628
Hauptverfasser:	Zachariadis, V, Gauffin, F, Kuchinskaya, E, Heyman, M, Schoumans, J, Blennow, E, Gustafsson, B, Barbany, G, Golovleva, I, Ehrencrona, H, Cavelier, L, Palmqvist, L, Lönnerholm, G, Nordenskjöld, M, Johansson, B, Forestier, E, Nordgren, A
Format:	Artikel
Sprache:	eng
Schlagworte:	20 20) dic(9 acute lymphoblastic leukemia FISH 631/208/2489/1381 692/699/67/1990/283/2125 692/700/1720 Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent B cells Biological and medical sciences Cancer and Oncology Cancer och onkologi Cancer Research Child Child, Preschool Childhood Children Chromosome Aberrations Chromosome Banding Chromosomes Chromosomes, Human, Pair 20 - genetics Chromosomes, Human, Pair 9 - genetics Clinical Medicine Critical Care Medicine dic Female FISH Fluorescence Fluorescence in situ hybridization Gene mutations Genetic aspects Genetics Health aspects Hematologic and hematopoietic diseases Hematology Hospitals Humans Hybridization In Situ Hybridization, Fluorescence Infant Intensive Internal Medicine Karyotyping Klinisk medicin Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes B Male Medical and Health Sciences Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicine & Public Health Oncology original-article Pediatrics Physiological aspects Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursors Prognosis Risk allocation Risk factors Subgroups Survival Rate Translocation, Genetic - genetics
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