The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial
The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence in situ hybridization analyses—i...
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| creator | Zachariadis, V Gauffin, F Kuchinskaya, E Heyman, M Schoumans, J Blennow, E Gustafsson, B Barbany, G Golovleva, I Ehrencrona, H Cavelier, L Palmqvist, L Lönnerholm, G Nordenskjöld, M Johansson, B Forestier, E Nordgren, A |
| description | The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence
in situ
hybridization analyses—in a three-step manner—using probes for: (i)
CDKN2A
at 9p21, (ii) 20p and 20q subtelomeres and (iii) cen9 and cen20. Out of 1033 BCP ALLs diagnosed from 2001 to 2006, 533 were analyzed; 16% (84/533) displayed 9p21 deletions, of which 30% (25/84) had dic(9;20). Thus, dic(9;20)-positivity was found in 4.7% (25/533), making it the third most common genetic subgroup after high hyperdiploidy and t(12;21)(p13;q22). The dic(9;20) was associated with a female predominance and an age peak at 3 years; 18/25 (72%) were allocated to non-standard risk treatment at diagnosis. Including cases detected by G-banding alone, 29 dic(9;20)-positive cases were treated according to the NOPHO ALL 2000 protocol. Relapses occurred in 24% (7/29) resulting in a 5-year event-free survival of 0.69, which was significantly worse than for t(12;21) (0.87;
P
=0.002) and high hyperdiploidy (0.82;
P
=0.04). We conclude that dic(9;20) is twice as common as previously surmised, with many cases going undetected by G-banding analysis, and that dic(9;20) should be considered a non-standard risk abnormality. |
| doi_str_mv | 10.1038/leu.2010.318 |
| format | Article |
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in situ
hybridization analyses—in a three-step manner—using probes for: (i)
CDKN2A
at 9p21, (ii) 20p and 20q subtelomeres and (iii) cen9 and cen20. Out of 1033 BCP ALLs diagnosed from 2001 to 2006, 533 were analyzed; 16% (84/533) displayed 9p21 deletions, of which 30% (25/84) had dic(9;20). Thus, dic(9;20)-positivity was found in 4.7% (25/533), making it the third most common genetic subgroup after high hyperdiploidy and t(12;21)(p13;q22). The dic(9;20) was associated with a female predominance and an age peak at 3 years; 18/25 (72%) were allocated to non-standard risk treatment at diagnosis. Including cases detected by G-banding alone, 29 dic(9;20)-positive cases were treated according to the NOPHO ALL 2000 protocol. Relapses occurred in 24% (7/29) resulting in a 5-year event-free survival of 0.69, which was significantly worse than for t(12;21) (0.87;
P
=0.002) and high hyperdiploidy (0.82;
P
=0.04). We conclude that dic(9;20) is twice as common as previously surmised, with many cases going undetected by G-banding analysis, and that dic(9;20) should be considered a non-standard risk abnormality.</description><identifier>ISSN: 0887-6924</identifier><identifier>ISSN: 1476-5551</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2010.318</identifier><identifier>PMID: 21242996</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>20 ; 20) dic(9 acute lymphoblastic leukemia FISH ; 631/208/2489/1381 ; 692/699/67/1990/283/2125 ; 692/700/1720 ; Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Adolescent ; B cells ; Biological and medical sciences ; Cancer and Oncology ; Cancer och onkologi ; Cancer Research ; Child ; Child, Preschool ; Childhood ; Children ; Chromosome Aberrations ; Chromosome Banding ; Chromosomes ; Chromosomes, Human, Pair 20 - genetics ; Chromosomes, Human, Pair 9 - genetics ; Clinical Medicine ; Critical Care Medicine ; dic ; Female ; FISH ; Fluorescence ; Fluorescence in situ hybridization ; Gene mutations ; Genetic aspects ; Genetics ; Health aspects ; Hematologic and hematopoietic diseases ; Hematology ; Hospitals ; Humans ; Hybridization ; In Situ Hybridization, Fluorescence ; Infant ; Intensive ; Internal Medicine ; Karyotyping ; Klinisk medicin ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic leukemia ; Lymphocytes B ; Male ; Medical and Health Sciences ; Medical prognosis ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Medicine & Public Health ; Oncology ; original-article ; Pediatrics ; Physiological aspects ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursors ; Prognosis ; Risk allocation ; Risk factors ; Subgroups ; Survival Rate ; Translocation, Genetic - genetics</subject><ispartof>Leukemia, 2011-04, Vol.25 (4), p.622-628</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2011.</rights><rights>Copyright Nature Publishing Group Apr 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c828t-a24ca1fd4c788827ff2ae36a347aae7171543f80c47c6a5ba7e102c2bc084b33</citedby><cites>FETCH-LOGICAL-c828t-a24ca1fd4c788827ff2ae36a347aae7171543f80c47c6a5ba7e102c2bc084b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2010.318$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2010.318$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24105100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21242996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40534$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152836$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1965535$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122390234$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Zachariadis, V</creatorcontrib><creatorcontrib>Gauffin, F</creatorcontrib><creatorcontrib>Kuchinskaya, E</creatorcontrib><creatorcontrib>Heyman, M</creatorcontrib><creatorcontrib>Schoumans, J</creatorcontrib><creatorcontrib>Blennow, E</creatorcontrib><creatorcontrib>Gustafsson, B</creatorcontrib><creatorcontrib>Barbany, G</creatorcontrib><creatorcontrib>Golovleva, I</creatorcontrib><creatorcontrib>Ehrencrona, H</creatorcontrib><creatorcontrib>Cavelier, L</creatorcontrib><creatorcontrib>Palmqvist, L</creatorcontrib><creatorcontrib>Lönnerholm, G</creatorcontrib><creatorcontrib>Nordenskjöld, M</creatorcontrib><creatorcontrib>Johansson, B</creatorcontrib><creatorcontrib>Forestier, E</creatorcontrib><creatorcontrib>Nordgren, A</creatorcontrib><creatorcontrib>Swedish Cytogenetic Leukemia Study Group (SCLSG)</creatorcontrib><creatorcontrib>Nordic Society of Pediatric Hematology, Oncology (NOPHO)</creatorcontrib><creatorcontrib>for the Nordic Society of Pediatric Hematology, Oncology (NOPHO) and the Swedish Cytogenetic Leukemia Study Group (SCLSG)</creatorcontrib><title>The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence
in situ
hybridization analyses—in a three-step manner—using probes for: (i)
CDKN2A
at 9p21, (ii) 20p and 20q subtelomeres and (iii) cen9 and cen20. Out of 1033 BCP ALLs diagnosed from 2001 to 2006, 533 were analyzed; 16% (84/533) displayed 9p21 deletions, of which 30% (25/84) had dic(9;20). Thus, dic(9;20)-positivity was found in 4.7% (25/533), making it the third most common genetic subgroup after high hyperdiploidy and t(12;21)(p13;q22). The dic(9;20) was associated with a female predominance and an age peak at 3 years; 18/25 (72%) were allocated to non-standard risk treatment at diagnosis. Including cases detected by G-banding alone, 29 dic(9;20)-positive cases were treated according to the NOPHO ALL 2000 protocol. Relapses occurred in 24% (7/29) resulting in a 5-year event-free survival of 0.69, which was significantly worse than for t(12;21) (0.87;
P
=0.002) and high hyperdiploidy (0.82;
P
=0.04). We conclude that dic(9;20) is twice as common as previously surmised, with many cases going undetected by G-banding analysis, and that dic(9;20) should be considered a non-standard risk abnormality.</description><subject>20</subject><subject>20) dic(9 acute lymphoblastic leukemia FISH</subject><subject>631/208/2489/1381</subject><subject>692/699/67/1990/283/2125</subject><subject>692/700/1720</subject><subject>Acute lymphoblastic leukemia</subject><subject>Acute lymphocytic leukemia</subject><subject>Adolescent</subject><subject>B cells</subject><subject>Biological and medical sciences</subject><subject>Cancer and Oncology</subject><subject>Cancer och onkologi</subject><subject>Cancer Research</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Banding</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 20 - genetics</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Clinical Medicine</subject><subject>Critical Care Medicine</subject><subject>dic</subject><subject>Female</subject><subject>FISH</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene mutations</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hybridization</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Infant</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Karyotyping</subject><subject>Klinisk medicin</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>original-article</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursors</subject><subject>Prognosis</subject><subject>Risk allocation</subject><subject>Risk factors</subject><subject>Subgroups</subject><subject>Survival Rate</subject><subject>Translocation, Genetic - genetics</subject><issn>0887-6924</issn><issn>1476-5551</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNk0tv1DAQxyMEoqVw44wsENBKZLEdv0JPS3kUaUU5VFwtx3F23Trx1o6F-mn4qjh06QO1AkVWnPFvZpz5zxTFUwRnCFbirTNphmH-qpC4V2wjwllJKUX3i20oBC9ZjclW8SjGEwinQ_aw2MIIE1zXbLv4ebwyoAvmLJlBnwM1tGAd_HLwcbQa2H6t9Ah8B1qrd-t9DPd216ia4f0zhGZ4D9gB6JV17cr7FrwvtXEu-xudQvQBKJ1GA9x5v175xqnfIfN1T01v1TsQTExujDm778GYr_H16NvhEZgvFiWGEIIxWOUeFw865aJ5snnvFMefPh4fHJaLo89fDuaLUgssxlJhohXqWqK5EALzrsPKVExVhCtlOOKIkqoTUBOumaKN4gZBrHGjoSBNVe0U5UXY-MOsUyPXwfYqnEuvrNyYTvPOSEoY4yjzizt5l9Z5NXlNDrhjhjWKSAMNlcS0rax5rbJdUNwa3HYc53Bv7gz3wX6fSx-WMiWJKBYV-0-8T5JAWpGMv77As7JZ5zjK3sZJKjUYn6IUnKCpauLfJMvKEE55Jp__RZ74FIYsUYYQg7gSU-IXd0GYkRwFY4avqKVyRtqh82NQekos55gSWhNR15ma3ULlp83dpP1gOpvtNxxeXXNYGeXGVfQujdYP8Sa4qaYOPsZgust6IiinEZO5Z-U0YjKPWMafbX4qNb1pL-E_M5WBlxtARa1cF9SgbbziCIIUQXit5_LRsDThqjq3Jv4FKfQ44A</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Zachariadis, V</creator><creator>Gauffin, F</creator><creator>Kuchinskaya, E</creator><creator>Heyman, M</creator><creator>Schoumans, J</creator><creator>Blennow, E</creator><creator>Gustafsson, B</creator><creator>Barbany, G</creator><creator>Golovleva, I</creator><creator>Ehrencrona, H</creator><creator>Cavelier, L</creator><creator>Palmqvist, L</creator><creator>Lönnerholm, G</creator><creator>Nordenskjöld, M</creator><creator>Johansson, B</creator><creator>Forestier, E</creator><creator>Nordgren, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope><scope>DF2</scope><scope>D95</scope></search><sort><creationdate>20110401</creationdate><title>The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial</title><author>Zachariadis, V ; Gauffin, F ; Kuchinskaya, E ; Heyman, M ; Schoumans, J ; Blennow, E ; Gustafsson, B ; Barbany, G ; Golovleva, I ; Ehrencrona, H ; Cavelier, L ; Palmqvist, L ; Lönnerholm, G ; Nordenskjöld, M ; Johansson, B ; Forestier, E ; Nordgren, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c828t-a24ca1fd4c788827ff2ae36a347aae7171543f80c47c6a5ba7e102c2bc084b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>20</topic><topic>20) dic(9 acute lymphoblastic leukemia FISH</topic><topic>631/208/2489/1381</topic><topic>692/699/67/1990/283/2125</topic><topic>692/700/1720</topic><topic>Acute lymphoblastic leukemia</topic><topic>Acute lymphocytic leukemia</topic><topic>Adolescent</topic><topic>B cells</topic><topic>Biological and medical sciences</topic><topic>Cancer and Oncology</topic><topic>Cancer och onkologi</topic><topic>Cancer Research</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Banding</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 20 - genetics</topic><topic>Chromosomes, Human, Pair 9 - genetics</topic><topic>Clinical Medicine</topic><topic>Critical Care Medicine</topic><topic>dic</topic><topic>Female</topic><topic>FISH</topic><topic>Fluorescence</topic><topic>Fluorescence in situ hybridization</topic><topic>Gene mutations</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hybridization</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Infant</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Karyotyping</topic><topic>Klinisk medicin</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic leukemia</topic><topic>Lymphocytes B</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>original-article</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursors</topic><topic>Prognosis</topic><topic>Risk allocation</topic><topic>Risk factors</topic><topic>Subgroups</topic><topic>Survival Rate</topic><topic>Translocation, Genetic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zachariadis, V</creatorcontrib><creatorcontrib>Gauffin, F</creatorcontrib><creatorcontrib>Kuchinskaya, E</creatorcontrib><creatorcontrib>Heyman, M</creatorcontrib><creatorcontrib>Schoumans, J</creatorcontrib><creatorcontrib>Blennow, E</creatorcontrib><creatorcontrib>Gustafsson, B</creatorcontrib><creatorcontrib>Barbany, G</creatorcontrib><creatorcontrib>Golovleva, I</creatorcontrib><creatorcontrib>Ehrencrona, H</creatorcontrib><creatorcontrib>Cavelier, L</creatorcontrib><creatorcontrib>Palmqvist, L</creatorcontrib><creatorcontrib>Lönnerholm, G</creatorcontrib><creatorcontrib>Nordenskjöld, M</creatorcontrib><creatorcontrib>Johansson, B</creatorcontrib><creatorcontrib>Forestier, E</creatorcontrib><creatorcontrib>Nordgren, A</creatorcontrib><creatorcontrib>Swedish Cytogenetic Leukemia Study Group (SCLSG)</creatorcontrib><creatorcontrib>Nordic Society of Pediatric Hematology, Oncology (NOPHO)</creatorcontrib><creatorcontrib>for the Nordic Society of Pediatric Hematology, Oncology (NOPHO) and the Swedish Cytogenetic Leukemia Study Group (SCLSG)</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Lunds universitet</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zachariadis, V</au><au>Gauffin, F</au><au>Kuchinskaya, E</au><au>Heyman, M</au><au>Schoumans, J</au><au>Blennow, E</au><au>Gustafsson, B</au><au>Barbany, G</au><au>Golovleva, I</au><au>Ehrencrona, H</au><au>Cavelier, L</au><au>Palmqvist, L</au><au>Lönnerholm, G</au><au>Nordenskjöld, M</au><au>Johansson, B</au><au>Forestier, E</au><au>Nordgren, A</au><aucorp>Swedish Cytogenetic Leukemia Study Group (SCLSG)</aucorp><aucorp>Nordic Society of Pediatric Hematology, Oncology (NOPHO)</aucorp><aucorp>for the Nordic Society of Pediatric Hematology, Oncology (NOPHO) and the Swedish Cytogenetic Leukemia Study Group (SCLSG)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>25</volume><issue>4</issue><spage>622</spage><epage>628</epage><pages>622-628</pages><issn>0887-6924</issn><issn>1476-5551</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence
in situ
hybridization analyses—in a three-step manner—using probes for: (i)
CDKN2A
at 9p21, (ii) 20p and 20q subtelomeres and (iii) cen9 and cen20. Out of 1033 BCP ALLs diagnosed from 2001 to 2006, 533 were analyzed; 16% (84/533) displayed 9p21 deletions, of which 30% (25/84) had dic(9;20). Thus, dic(9;20)-positivity was found in 4.7% (25/533), making it the third most common genetic subgroup after high hyperdiploidy and t(12;21)(p13;q22). The dic(9;20) was associated with a female predominance and an age peak at 3 years; 18/25 (72%) were allocated to non-standard risk treatment at diagnosis. Including cases detected by G-banding alone, 29 dic(9;20)-positive cases were treated according to the NOPHO ALL 2000 protocol. Relapses occurred in 24% (7/29) resulting in a 5-year event-free survival of 0.69, which was significantly worse than for t(12;21) (0.87;
P
=0.002) and high hyperdiploidy (0.82;
P
=0.04). We conclude that dic(9;20) is twice as common as previously surmised, with many cases going undetected by G-banding analysis, and that dic(9;20) should be considered a non-standard risk abnormality.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21242996</pmid><doi>10.1038/leu.2010.318</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2011-04, Vol.25 (4), p.622-628 |
| issn | 0887-6924 1476-5551 1476-5551 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_546671 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 20 20) dic(9 acute lymphoblastic leukemia FISH 631/208/2489/1381 692/699/67/1990/283/2125 692/700/1720 Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent B cells Biological and medical sciences Cancer and Oncology Cancer och onkologi Cancer Research Child Child, Preschool Childhood Children Chromosome Aberrations Chromosome Banding Chromosomes Chromosomes, Human, Pair 20 - genetics Chromosomes, Human, Pair 9 - genetics Clinical Medicine Critical Care Medicine dic Female FISH Fluorescence Fluorescence in situ hybridization Gene mutations Genetic aspects Genetics Health aspects Hematologic and hematopoietic diseases Hematology Hospitals Humans Hybridization In Situ Hybridization, Fluorescence Infant Intensive Internal Medicine Karyotyping Klinisk medicin Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes B Male Medical and Health Sciences Medical prognosis Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicine & Public Health Oncology original-article Pediatrics Physiological aspects Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursors Prognosis Risk allocation Risk factors Subgroups Survival Rate Translocation, Genetic - genetics |
| title | The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial |
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