A novel screening method detects herpesviral DNA in the idiopathic pulmonary fibrosis lung

Abstract Background. Herpesviruses could contribute to the lung epithelial injury that initiates profibrotic responses in idiopathic pulmonary fibrosis (IPF). Methods. We identified herpesviral DNA from IPF and control lung tissue using a multiplex PCR-and microarray-based method. Active herpesviral...

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Veröffentlicht in:	Annals of medicine (Helsinki) 2012-03, Vol.44 (2), p.178-186
Hauptverfasser:	Pulkkinen, Ville, Salmenkivi, Kaisa, Kinnula, Vuokko L., Sutinen, Eva, Halme, Maija, Hodgson, Ulla, Lehto, Juho, Jääskeläinen, Anne, Piiparinen, Heli, Kere, Juha, Lautenschlager, Irmeli, Lappalainen, Maija, Myllärniemi, Marjukka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged DNA, Viral - analysis Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - pathology Female Herpesvirus Herpesvirus 4, Human - genetics Herpesvirus 4, Human - immunology Herpesvirus 4, Human - isolation & purification Herpesvirus 6, Human - genetics Herpesvirus 6, Human - immunology Herpesvirus 6, Human - isolation & purification Humans Idiopathic Pulmonary Fibrosis - virology interstitial fibrosis Lung - virology Lung Transplantation - adverse effects lymphocytes Male Middle Aged Multiplex Polymerase Chain Reaction Roseolovirus Infections - complications Roseolovirus Infections - pathology viral infection
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