Effects of a School-Based Prevention Program on European Adolescents' Patterns of Alcohol Use

Abstract Purpose School-based substance abuse prevention programs are widespread but are rarely evaluated in Europe. We aimed to evaluate the effect of a new school-based prevention program against substance use on the frequency of alcohol consumption and alcohol-related problem behaviors among Euro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of adolescent health 2011-02, Vol.48 (2), p.182-188
Hauptverfasser: Caria, Maria Paola, M.Sc, Faggiano, Fabrizio, M.D., Ph.D, Bellocco, Rino, Sc.D, Galanti, Maria Rosaria, M.D., Ph.D
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 188
container_issue 2
container_start_page 182
container_title Journal of adolescent health
container_volume 48
creator Caria, Maria Paola, M.Sc
Faggiano, Fabrizio, M.D., Ph.D
Bellocco, Rino, Sc.D
Galanti, Maria Rosaria, M.D., Ph.D
description Abstract Purpose School-based substance abuse prevention programs are widespread but are rarely evaluated in Europe. We aimed to evaluate the effect of a new school-based prevention program against substance use on the frequency of alcohol consumption and alcohol-related problem behaviors among European students. Methods During the school year 2004–2005, a total of 7,079 students aged 12–14 years from 143 schools in seven European countries participated in this cluster randomized controlled trial. Schools were randomly assigned to either control (65 schools, 3,532 students) or to a 12-session standardized program based on the comprehensive social influence model (78 schools, 3,547 students). Alcohol use and frequency of alcohol-related problem behaviors were investigated through a self-completed anonymous questionnaire at baseline and 18 months thereafter. The association between intervention and changes in alcohol-related outcomes was expressed as odds ratio (OR), estimated by multilevel regression model. Results The preventive program was associated with a decreased risk of reporting alcohol-related problems (OR = .78, 95% confidence intervals [CI] = .63–.98), although this reduction was not statistically significant in the subgroup of 743 current drinkers at baseline. The risk for alcohol consumption was not modified by exposure to the program (OR = .93, 95% CI = .79–1.09). In the intervention group, nondrinkers and occasional drinkers at baseline progressed toward frequent drinking less often than in the control group. Conclusions School curricula based on the comprehensive social-influence model can delay progression to frequent drinking and reduce occurrence of alcohol-related behavioral problems in European students. These results, albeit moderate, have potentially useful implications at the population level.
doi_str_mv 10.1016/j.jadohealth.2010.06.003
format Article
fullrecord <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_546560</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1054139X10002673</els_id><sourcerecordid>855899986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c610t-c89ea93a8179da09a345c8fa5f2a3bb5eb244fb926f63408a196cfd07ecf9c33</originalsourceid><addsrcrecordid>eNqNkk1r3DAQhk1padK0f6H4UnLyVh-2LF0Km7D9gEADSaGXImR51JXjtbaSnZB_33F3k4VCSU8axPPODNKTZTklC0qoeN8tOtOGNZh-XC8YwWsiFoTwZ9kxlbUqqKrZc6xJVRaUq-9H2auUOoJRQcnL7IhRVtWUyuPsx8o5sGPKg8tNfmXXIfTFmUnQ5pcRbmEYfRiwDD-j2eRYrqYYtmCGfNmGHpJFIp3ml2YcIQ5_2ix7G9ahz78leJ29cKZP8GZ_nmTXH1fX55-Li6-fvpwvLwqL-4yFlQqM4kbSWrWGKMPLykpnKscMb5oKGlaWrlFMOMFLIg1VwrqW1GCdspyfZMWubbqD7dTobfQbE-91MF7vr26wAl2VohIEefVPfhtDewg9BCljROGjScye7rII_pogjXrj8RX63gwQpqQVzqB1WZInSVlVUiklxdNkWTPEyEzKHWljSCmCe9ydEj2roTt9UEPPamgiNKqB0bf7IVOzgfYx-OACAu_2gEnW9C6awfp04LgUFRVzo7MdB_ijtx6iTtbDYKH1EVXSbfD_s82Hv5rY3g8e597APaQuTHFAYzTViWmir2aVZ5MpIYSJmvPf9YjyCg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>847286306</pqid></control><display><type>article</type><title>Effects of a School-Based Prevention Program on European Adolescents' Patterns of Alcohol Use</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Applied Social Sciences Index &amp; Abstracts (ASSIA)</source><creator>Caria, Maria Paola, M.Sc ; Faggiano, Fabrizio, M.D., Ph.D ; Bellocco, Rino, Sc.D ; Galanti, Maria Rosaria, M.D., Ph.D</creator><creatorcontrib>Caria, Maria Paola, M.Sc ; Faggiano, Fabrizio, M.D., Ph.D ; Bellocco, Rino, Sc.D ; Galanti, Maria Rosaria, M.D., Ph.D ; EU-Dap Study Group</creatorcontrib><description>Abstract Purpose School-based substance abuse prevention programs are widespread but are rarely evaluated in Europe. We aimed to evaluate the effect of a new school-based prevention program against substance use on the frequency of alcohol consumption and alcohol-related problem behaviors among European students. Methods During the school year 2004–2005, a total of 7,079 students aged 12–14 years from 143 schools in seven European countries participated in this cluster randomized controlled trial. Schools were randomly assigned to either control (65 schools, 3,532 students) or to a 12-session standardized program based on the comprehensive social influence model (78 schools, 3,547 students). Alcohol use and frequency of alcohol-related problem behaviors were investigated through a self-completed anonymous questionnaire at baseline and 18 months thereafter. The association between intervention and changes in alcohol-related outcomes was expressed as odds ratio (OR), estimated by multilevel regression model. Results The preventive program was associated with a decreased risk of reporting alcohol-related problems (OR = .78, 95% confidence intervals [CI] = .63–.98), although this reduction was not statistically significant in the subgroup of 743 current drinkers at baseline. The risk for alcohol consumption was not modified by exposure to the program (OR = .93, 95% CI = .79–1.09). In the intervention group, nondrinkers and occasional drinkers at baseline progressed toward frequent drinking less often than in the control group. Conclusions School curricula based on the comprehensive social-influence model can delay progression to frequent drinking and reduce occurrence of alcohol-related behavioral problems in European students. These results, albeit moderate, have potentially useful implications at the population level.</description><identifier>ISSN: 1054-139X</identifier><identifier>ISSN: 1879-1972</identifier><identifier>EISSN: 1879-1972</identifier><identifier>DOI: 10.1016/j.jadohealth.2010.06.003</identifier><identifier>PMID: 21257118</identifier><identifier>CODEN: JAHCD9</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Addictive behaviors ; Adolescent ; Adult and adolescent clinical studies ; Alcohol abuse ; Alcohol consumption ; Alcohol Drinking - prevention &amp; control ; Alcohol related problems ; Alcohol-Related Disorders - prevention &amp; control ; Alcoholism ; Alcoholism and acute alcohol poisoning ; Behavioural problems ; Biological and medical sciences ; Child ; Comprehensive social influence model ; Curriculum ; Decision Making ; Europe ; Female ; Health Behavior ; Health Education - methods ; Humans ; Interpersonal Relations ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Mental health ; Outcome Assessment (Health Care) ; Pediatrics ; Prevention. Health policy. Planification ; Preventive programmes ; Problem Solving ; Program evaluation ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Randomized controlled trial ; School based ; School Health Services ; School-based prevention ; Social Behavior ; Social psychiatry. Ethnopsychiatry ; Substance abuse ; Toxicology</subject><ispartof>Journal of adolescent health, 2011-02, Vol.48 (2), p.182-188</ispartof><rights>Society for Adolescent Health and Medicine</rights><rights>2011 Society for Adolescent Health and Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-c89ea93a8179da09a345c8fa5f2a3bb5eb244fb926f63408a196cfd07ecf9c33</citedby><cites>FETCH-LOGICAL-c610t-c89ea93a8179da09a345c8fa5f2a3bb5eb244fb926f63408a196cfd07ecf9c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jadohealth.2010.06.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,31000,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=23865163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21257118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122091258$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Caria, Maria Paola, M.Sc</creatorcontrib><creatorcontrib>Faggiano, Fabrizio, M.D., Ph.D</creatorcontrib><creatorcontrib>Bellocco, Rino, Sc.D</creatorcontrib><creatorcontrib>Galanti, Maria Rosaria, M.D., Ph.D</creatorcontrib><creatorcontrib>EU-Dap Study Group</creatorcontrib><title>Effects of a School-Based Prevention Program on European Adolescents' Patterns of Alcohol Use</title><title>Journal of adolescent health</title><addtitle>J Adolesc Health</addtitle><description>Abstract Purpose School-based substance abuse prevention programs are widespread but are rarely evaluated in Europe. We aimed to evaluate the effect of a new school-based prevention program against substance use on the frequency of alcohol consumption and alcohol-related problem behaviors among European students. Methods During the school year 2004–2005, a total of 7,079 students aged 12–14 years from 143 schools in seven European countries participated in this cluster randomized controlled trial. Schools were randomly assigned to either control (65 schools, 3,532 students) or to a 12-session standardized program based on the comprehensive social influence model (78 schools, 3,547 students). Alcohol use and frequency of alcohol-related problem behaviors were investigated through a self-completed anonymous questionnaire at baseline and 18 months thereafter. The association between intervention and changes in alcohol-related outcomes was expressed as odds ratio (OR), estimated by multilevel regression model. Results The preventive program was associated with a decreased risk of reporting alcohol-related problems (OR = .78, 95% confidence intervals [CI] = .63–.98), although this reduction was not statistically significant in the subgroup of 743 current drinkers at baseline. The risk for alcohol consumption was not modified by exposure to the program (OR = .93, 95% CI = .79–1.09). In the intervention group, nondrinkers and occasional drinkers at baseline progressed toward frequent drinking less often than in the control group. Conclusions School curricula based on the comprehensive social-influence model can delay progression to frequent drinking and reduce occurrence of alcohol-related behavioral problems in European students. These results, albeit moderate, have potentially useful implications at the population level.</description><subject>Addictive behaviors</subject><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcohol abuse</subject><subject>Alcohol consumption</subject><subject>Alcohol Drinking - prevention &amp; control</subject><subject>Alcohol related problems</subject><subject>Alcohol-Related Disorders - prevention &amp; control</subject><subject>Alcoholism</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Behavioural problems</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Comprehensive social influence model</subject><subject>Curriculum</subject><subject>Decision Making</subject><subject>Europe</subject><subject>Female</subject><subject>Health Behavior</subject><subject>Health Education - methods</subject><subject>Humans</subject><subject>Interpersonal Relations</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Mental health</subject><subject>Outcome Assessment (Health Care)</subject><subject>Pediatrics</subject><subject>Prevention. Health policy. Planification</subject><subject>Preventive programmes</subject><subject>Problem Solving</subject><subject>Program evaluation</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Randomized controlled trial</subject><subject>School based</subject><subject>School Health Services</subject><subject>School-based prevention</subject><subject>Social Behavior</subject><subject>Social psychiatry. Ethnopsychiatry</subject><subject>Substance abuse</subject><subject>Toxicology</subject><issn>1054-139X</issn><issn>1879-1972</issn><issn>1879-1972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk1r3DAQhk1padK0f6H4UnLyVh-2LF0Km7D9gEADSaGXImR51JXjtbaSnZB_33F3k4VCSU8axPPODNKTZTklC0qoeN8tOtOGNZh-XC8YwWsiFoTwZ9kxlbUqqKrZc6xJVRaUq-9H2auUOoJRQcnL7IhRVtWUyuPsx8o5sGPKg8tNfmXXIfTFmUnQ5pcRbmEYfRiwDD-j2eRYrqYYtmCGfNmGHpJFIp3ml2YcIQ5_2ix7G9ahz78leJ29cKZP8GZ_nmTXH1fX55-Li6-fvpwvLwqL-4yFlQqM4kbSWrWGKMPLykpnKscMb5oKGlaWrlFMOMFLIg1VwrqW1GCdspyfZMWubbqD7dTobfQbE-91MF7vr26wAl2VohIEefVPfhtDewg9BCljROGjScye7rII_pogjXrj8RX63gwQpqQVzqB1WZInSVlVUiklxdNkWTPEyEzKHWljSCmCe9ydEj2roTt9UEPPamgiNKqB0bf7IVOzgfYx-OACAu_2gEnW9C6awfp04LgUFRVzo7MdB_ijtx6iTtbDYKH1EVXSbfD_s82Hv5rY3g8e597APaQuTHFAYzTViWmir2aVZ5MpIYSJmvPf9YjyCg</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Caria, Maria Paola, M.Sc</creator><creator>Faggiano, Fabrizio, M.D., Ph.D</creator><creator>Bellocco, Rino, Sc.D</creator><creator>Galanti, Maria Rosaria, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QJ</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20110201</creationdate><title>Effects of a School-Based Prevention Program on European Adolescents' Patterns of Alcohol Use</title><author>Caria, Maria Paola, M.Sc ; Faggiano, Fabrizio, M.D., Ph.D ; Bellocco, Rino, Sc.D ; Galanti, Maria Rosaria, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-c89ea93a8179da09a345c8fa5f2a3bb5eb244fb926f63408a196cfd07ecf9c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Addictive behaviors</topic><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Alcohol abuse</topic><topic>Alcohol consumption</topic><topic>Alcohol Drinking - prevention &amp; control</topic><topic>Alcohol related problems</topic><topic>Alcohol-Related Disorders - prevention &amp; control</topic><topic>Alcoholism</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Behavioural problems</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Comprehensive social influence model</topic><topic>Curriculum</topic><topic>Decision Making</topic><topic>Europe</topic><topic>Female</topic><topic>Health Behavior</topic><topic>Health Education - methods</topic><topic>Humans</topic><topic>Interpersonal Relations</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Mental health</topic><topic>Outcome Assessment (Health Care)</topic><topic>Pediatrics</topic><topic>Prevention. Health policy. Planification</topic><topic>Preventive programmes</topic><topic>Problem Solving</topic><topic>Program evaluation</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Randomized controlled trial</topic><topic>School based</topic><topic>School Health Services</topic><topic>School-based prevention</topic><topic>Social Behavior</topic><topic>Social psychiatry. Ethnopsychiatry</topic><topic>Substance abuse</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caria, Maria Paola, M.Sc</creatorcontrib><creatorcontrib>Faggiano, Fabrizio, M.D., Ph.D</creatorcontrib><creatorcontrib>Bellocco, Rino, Sc.D</creatorcontrib><creatorcontrib>Galanti, Maria Rosaria, M.D., Ph.D</creatorcontrib><creatorcontrib>EU-Dap Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index &amp; Abstracts (ASSIA)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of adolescent health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caria, Maria Paola, M.Sc</au><au>Faggiano, Fabrizio, M.D., Ph.D</au><au>Bellocco, Rino, Sc.D</au><au>Galanti, Maria Rosaria, M.D., Ph.D</au><aucorp>EU-Dap Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a School-Based Prevention Program on European Adolescents' Patterns of Alcohol Use</atitle><jtitle>Journal of adolescent health</jtitle><addtitle>J Adolesc Health</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>48</volume><issue>2</issue><spage>182</spage><epage>188</epage><pages>182-188</pages><issn>1054-139X</issn><issn>1879-1972</issn><eissn>1879-1972</eissn><coden>JAHCD9</coden><abstract>Abstract Purpose School-based substance abuse prevention programs are widespread but are rarely evaluated in Europe. We aimed to evaluate the effect of a new school-based prevention program against substance use on the frequency of alcohol consumption and alcohol-related problem behaviors among European students. Methods During the school year 2004–2005, a total of 7,079 students aged 12–14 years from 143 schools in seven European countries participated in this cluster randomized controlled trial. Schools were randomly assigned to either control (65 schools, 3,532 students) or to a 12-session standardized program based on the comprehensive social influence model (78 schools, 3,547 students). Alcohol use and frequency of alcohol-related problem behaviors were investigated through a self-completed anonymous questionnaire at baseline and 18 months thereafter. The association between intervention and changes in alcohol-related outcomes was expressed as odds ratio (OR), estimated by multilevel regression model. Results The preventive program was associated with a decreased risk of reporting alcohol-related problems (OR = .78, 95% confidence intervals [CI] = .63–.98), although this reduction was not statistically significant in the subgroup of 743 current drinkers at baseline. The risk for alcohol consumption was not modified by exposure to the program (OR = .93, 95% CI = .79–1.09). In the intervention group, nondrinkers and occasional drinkers at baseline progressed toward frequent drinking less often than in the control group. Conclusions School curricula based on the comprehensive social-influence model can delay progression to frequent drinking and reduce occurrence of alcohol-related behavioral problems in European students. These results, albeit moderate, have potentially useful implications at the population level.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21257118</pmid><doi>10.1016/j.jadohealth.2010.06.003</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1054-139X
ispartof Journal of adolescent health, 2011-02, Vol.48 (2), p.182-188
issn 1054-139X
1879-1972
1879-1972
language eng
recordid cdi_swepub_primary_oai_swepub_ki_se_546560
source MEDLINE; Elsevier ScienceDirect Journals Complete; Applied Social Sciences Index & Abstracts (ASSIA)
subjects Addictive behaviors
Adolescent
Adult and adolescent clinical studies
Alcohol abuse
Alcohol consumption
Alcohol Drinking - prevention & control
Alcohol related problems
Alcohol-Related Disorders - prevention & control
Alcoholism
Alcoholism and acute alcohol poisoning
Behavioural problems
Biological and medical sciences
Child
Comprehensive social influence model
Curriculum
Decision Making
Europe
Female
Health Behavior
Health Education - methods
Humans
Interpersonal Relations
Male
Medical sciences
Medicin och hälsovetenskap
Mental health
Outcome Assessment (Health Care)
Pediatrics
Prevention. Health policy. Planification
Preventive programmes
Problem Solving
Program evaluation
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Randomized controlled trial
School based
School Health Services
School-based prevention
Social Behavior
Social psychiatry. Ethnopsychiatry
Substance abuse
Toxicology
title Effects of a School-Based Prevention Program on European Adolescents' Patterns of Alcohol Use
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T03%3A04%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%20School-Based%20Prevention%20Program%20on%20European%20Adolescents'%20Patterns%20of%20Alcohol%20Use&rft.jtitle=Journal%20of%20adolescent%20health&rft.au=Caria,%20Maria%20Paola,%20M.Sc&rft.aucorp=EU-Dap%20Study%20Group&rft.date=2011-02-01&rft.volume=48&rft.issue=2&rft.spage=182&rft.epage=188&rft.pages=182-188&rft.issn=1054-139X&rft.eissn=1879-1972&rft.coden=JAHCD9&rft_id=info:doi/10.1016/j.jadohealth.2010.06.003&rft_dat=%3Cproquest_swepu%3E855899986%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=847286306&rft_id=info:pmid/21257118&rft_els_id=1_s2_0_S1054139X10002673&rfr_iscdi=true