Dopamine D1 Receptor Associations within and between Dopaminergic Pathways in Younger and Elderly Adults: Links to Cognitive Performance

Age-related dopamine (DA) losses have been extensively demonstrated for the D2 receptor subtype. Comparatively little is known about adult age changes regarding D1 receptors. In this study, we demonstrate marked age-related D1 receptor losses in striatal, limbic, and cortical areas using positron em...

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Veröffentlicht in:	Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2011-09, Vol.21 (9), p.2023-2032
Hauptverfasser:	Rieckmann, Anna, Karlsson, Sari, Karlsson, Per, Brehmer, Yvonne, Fischer, Håkan, Farde, Lars, Nyberg, Lars, Bäckman, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged aging Aging - physiology Algorithms Blood Pressure - physiology Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiology Cognition Cognition - physiology D1 receptors Dopamine Dopamine - physiology Female Humans Magnetic Resonance Imaging Male Motor Skills - physiology Neuropsychological Tests PET Positron-Emission Tomography Prefrontal Cortex - physiology Psychology Psychomotor Performance - physiology Psykologi Reaction Time - physiology Receptors, Dopamine D1 - physiology Rest - physiology SAMHÄLLSVETENSKAP SCH23390 Signal Transduction - physiology SOCIAL SCIENCES Socialvetenskap Young Adult
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