Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine

The main objectives of the present study were (i) to measure density changes of activated microglia and the peripheral benzodiazepine receptor/translocator protein (TSPO) system during normal ageing in the human brain with positron emission tomography (PET) using the TSPO molecular imaging biomarker...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2011-06, Vol.56 (3), p.1111-1121
Hauptverfasser:	Gulyás, Balázs, Vas, Ádám, Tóth, Miklós, Takano, Akihiro, Varrone, Andrea, Cselényi, Zsolt, Schain, Martin, Mattsson, Patrik, Halldin, Christer
Format:	Artikel
Sprache:	eng
Schlagworte:	[11C]vinpocetine Adult Age Aged Aged, 80 and over Ageing Aging Aging - physiology Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer's disease (AD) Brain Brain - diagnostic imaging Brain - metabolism Brain uptake Data Interpretation, Statistical Female Humans Hypotheses Image Processing, Computer-Assisted Imaging biomarker Inhomogeneity analysis Isotope Labeling Ligands Male Microglia Middle Aged Molecular imaging Peripheral benzodiazepine receptor (PBR) Positron emission tomography (PET) Positron-Emission Tomography Proteins Radiopharmaceuticals Receptors, GABA - metabolism Rodents Studies Translocator protein (TSPO) Vinca Alkaloids
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