Mast Cells Increase Vascular Permeability by Heparin-Initiated Bradykinin Formation In Vivo

Activated mast cells trigger edema in allergic and inflammatory disease. We report a paracrine mechanism by which mast cell-released heparin increases vascular permeability in vivo. Heparin activated the protease factor XII, which initiates bradykinin formation in plasma. Targeting factor XII or kin...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2011-02, Vol.34 (2), p.258-268
Hauptverfasser:	Oschatz, Chris, Maas, Coen, Lecher, Bernd, Jansen, Thomas, Björkqvist, Jenny, Tradler, Thomas, Sedlmeier, Reinhard, Burfeind, Peter, Cichon, Sven, Hammerschmidt, Sven, Müller-Esterl, Werner, Wuillemin, Walter A., Nilsson, Gunnar, Renné, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood pressure Bradykinin - biosynthesis Bradykinin - genetics Capillary Leak Syndrome - etiology Capillary Leak Syndrome - physiopathology Capillary Permeability - physiology Cell Adhesion Complement C1 Inhibitor Protein - physiology Edema - etiology Edema - physiopathology Endothelial Cells - pathology Enzyme Activation Factor XII - physiology Heparan sulfate Heparin - physiology Heparin - secretion Hypotension - etiology Hypotension - physiopathology Immunoglobulin E - immunology Kallikrein-Kinin System - physiology Leukocytes - physiology Male Mast Cells - secretion Mice Paracrine Communication - physiology Passive Cutaneous Anaphylaxis - physiology Permeability Plasma Pressure transducers Rats Rodents Signal Transduction - physiology Skin - blood supply Veins & arteries
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