Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients
Background: Aortic stenosis patients often show bleeding complications. Previously, a prolonged platelet function analyzer (PFA‐100) closure time was observed with plasma of severe aortic stenosis patients. To elucidate a possible role of circulating preactivated von Willebrand factor (VWF), we dete...
Gespeichert in:
| Veröffentlicht in: | JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2011-05, Vol.9 (5), p.953-958 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 958 |
|---|---|
| container_issue | 5 |
| container_start_page | 953 |
| container_title | JOURNAL OF THROMBOSIS AND HAEMOSTASIS |
| container_volume | 9 |
| creator | HOLLESTELLE, M. J. LOOTS, C. M. SQUIZZATO, A. RENNÉ, T. BOUMA, B. J. DE GROOT, P. G. LENTING, P. J. MEIJERS, J. C. M. GERDES, V. E. A. |
| description | Background: Aortic stenosis patients often show bleeding complications. Previously, a prolonged platelet function analyzer (PFA‐100) closure time was observed with plasma of severe aortic stenosis patients. To elucidate a possible role of circulating preactivated von Willebrand factor (VWF), we determined the level of VWF in its active, platelet‐binding conformation in plasma of patients with aortic stenosis. Patients/methods: Sixty‐two aortic stenosis patients were included in this study. VWF and related parameters were measured, and the results were related to severity of aortic stenosis. Results: VWF activation factor, indicating the proportion of circulating VWF able to bind to platelets, correlated negatively with peak transvalvular gradient and PFA‐100 closure time. No correlation was observed between ADAMTS13 activity and peak transvalvular gradient or PFA‐100 closure time. Both VWF antigen and VWF propeptide levels were significantly higher in patients with mild and moderate aortic stenosis, but not in those with severe stenosis. Conclusions: Our data demonstrate that the aortic pressure gradient is inversely associated with VWF activation factor, but not with VWF antigen or VWF multimerization in patients with aortic stenosis. These findings might have implications for the bleeding observed in patients with aortic stenosis. |
| doi_str_mv | 10.1111/j.1538-7836.2011.04247.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_545921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3834850751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4527-fa14564a4cc5b6f8d4451feb796c3d33b4aeb2d4a6c55d0d187716aeb0ad93d43</originalsourceid><addsrcrecordid>eNqNUc1u3CAYRFWqJtn0FSKknO2CAWMfeqg2aTdVpF626i0Iw-eEjdc44P3J2xd3N3suF0bDfAPMIIQpyWlaX1Y5FazKZMXKvCCU5oQXXOb7D-jidHD2jmvGztFljCtCaC0K8gmdF5SJgpf1BXq8BRNAR7BYm9FtAW99j_-4roMm6N7iNtE-4A620GG_c_0THj2Oz6ADjmOAGLHrsfZhdCYR0PvoIh706KAf4xX62OouwufjPkO_v98t54vs4deP-_m3h8xwUcis1ZSLkmtujGjKtrKcC9pCI-vSMMtYwzU0heW6NEJYYmklJS0TR7StmeVshrKDb9zBsGnUENxahzfltVNH6iUhUIKLOv1-hm4O-iH41w3EUa38JvTpiYrKgsqaSzm5VgeVCT7GAO3JlxI1FaFWaspYTXmrqQj1rwi1T6PXxws2zRrsafA9-ST4ehDsXAdv_22sfi4XE2J_ATX2mJU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1721794774</pqid></control><display><type>article</type><title>Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><creator>HOLLESTELLE, M. J. ; LOOTS, C. M. ; SQUIZZATO, A. ; RENNÉ, T. ; BOUMA, B. J. ; DE GROOT, P. G. ; LENTING, P. J. ; MEIJERS, J. C. M. ; GERDES, V. E. A.</creator><creatorcontrib>HOLLESTELLE, M. J. ; LOOTS, C. M. ; SQUIZZATO, A. ; RENNÉ, T. ; BOUMA, B. J. ; DE GROOT, P. G. ; LENTING, P. J. ; MEIJERS, J. C. M. ; GERDES, V. E. A.</creatorcontrib><description>Background: Aortic stenosis patients often show bleeding complications. Previously, a prolonged platelet function analyzer (PFA‐100) closure time was observed with plasma of severe aortic stenosis patients. To elucidate a possible role of circulating preactivated von Willebrand factor (VWF), we determined the level of VWF in its active, platelet‐binding conformation in plasma of patients with aortic stenosis. Patients/methods: Sixty‐two aortic stenosis patients were included in this study. VWF and related parameters were measured, and the results were related to severity of aortic stenosis. Results: VWF activation factor, indicating the proportion of circulating VWF able to bind to platelets, correlated negatively with peak transvalvular gradient and PFA‐100 closure time. No correlation was observed between ADAMTS13 activity and peak transvalvular gradient or PFA‐100 closure time. Both VWF antigen and VWF propeptide levels were significantly higher in patients with mild and moderate aortic stenosis, but not in those with severe stenosis. Conclusions: Our data demonstrate that the aortic pressure gradient is inversely associated with VWF activation factor, but not with VWF antigen or VWF multimerization in patients with aortic stenosis. These findings might have implications for the bleeding observed in patients with aortic stenosis.</description><identifier>ISSN: 1538-7933</identifier><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1111/j.1538-7836.2011.04247.x</identifier><identifier>PMID: 21352469</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ADAM Proteins - blood ; ADAMTS13 Protein ; Aged ; Antigens ; aortic stenosis ; Aortic Valve Stenosis - blood ; Aortic Valve Stenosis - pathology ; Cardiology ; Electrocardiography ; Female ; Hemorrhage ; Hemostasis ; Humans ; Male ; Middle Aged ; Peptides - chemistry ; platelet ; Platelet Function Tests ; Shear Strength ; Stress, Mechanical ; Surveys and Questionnaires ; von Willebrand factor ; von Willebrand Factor - biosynthesis ; von Willebrand factor propeptide</subject><ispartof>JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011-05, Vol.9 (5), p.953-958</ispartof><rights>2011 International Society on Thrombosis and Haemostasis</rights><rights>2011 International Society on Thrombosis and Haemostasis.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4527-fa14564a4cc5b6f8d4451feb796c3d33b4aeb2d4a6c55d0d187716aeb0ad93d43</citedby><cites>FETCH-LOGICAL-c4527-fa14564a4cc5b6f8d4451feb796c3d33b4aeb2d4a6c55d0d187716aeb0ad93d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21352469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122554244$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>HOLLESTELLE, M. J.</creatorcontrib><creatorcontrib>LOOTS, C. M.</creatorcontrib><creatorcontrib>SQUIZZATO, A.</creatorcontrib><creatorcontrib>RENNÉ, T.</creatorcontrib><creatorcontrib>BOUMA, B. J.</creatorcontrib><creatorcontrib>DE GROOT, P. G.</creatorcontrib><creatorcontrib>LENTING, P. J.</creatorcontrib><creatorcontrib>MEIJERS, J. C. M.</creatorcontrib><creatorcontrib>GERDES, V. E. A.</creatorcontrib><title>Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients</title><title>JOURNAL OF THROMBOSIS AND HAEMOSTASIS</title><addtitle>J Thromb Haemost</addtitle><description>Background: Aortic stenosis patients often show bleeding complications. Previously, a prolonged platelet function analyzer (PFA‐100) closure time was observed with plasma of severe aortic stenosis patients. To elucidate a possible role of circulating preactivated von Willebrand factor (VWF), we determined the level of VWF in its active, platelet‐binding conformation in plasma of patients with aortic stenosis. Patients/methods: Sixty‐two aortic stenosis patients were included in this study. VWF and related parameters were measured, and the results were related to severity of aortic stenosis. Results: VWF activation factor, indicating the proportion of circulating VWF able to bind to platelets, correlated negatively with peak transvalvular gradient and PFA‐100 closure time. No correlation was observed between ADAMTS13 activity and peak transvalvular gradient or PFA‐100 closure time. Both VWF antigen and VWF propeptide levels were significantly higher in patients with mild and moderate aortic stenosis, but not in those with severe stenosis. Conclusions: Our data demonstrate that the aortic pressure gradient is inversely associated with VWF activation factor, but not with VWF antigen or VWF multimerization in patients with aortic stenosis. These findings might have implications for the bleeding observed in patients with aortic stenosis.</description><subject>ADAM Proteins - blood</subject><subject>ADAMTS13 Protein</subject><subject>Aged</subject><subject>Antigens</subject><subject>aortic stenosis</subject><subject>Aortic Valve Stenosis - blood</subject><subject>Aortic Valve Stenosis - pathology</subject><subject>Cardiology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Hemorrhage</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptides - chemistry</subject><subject>platelet</subject><subject>Platelet Function Tests</subject><subject>Shear Strength</subject><subject>Stress, Mechanical</subject><subject>Surveys and Questionnaires</subject><subject>von Willebrand factor</subject><subject>von Willebrand Factor - biosynthesis</subject><subject>von Willebrand factor propeptide</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNUc1u3CAYRFWqJtn0FSKknO2CAWMfeqg2aTdVpF626i0Iw-eEjdc44P3J2xd3N3suF0bDfAPMIIQpyWlaX1Y5FazKZMXKvCCU5oQXXOb7D-jidHD2jmvGztFljCtCaC0K8gmdF5SJgpf1BXq8BRNAR7BYm9FtAW99j_-4roMm6N7iNtE-4A620GG_c_0THj2Oz6ADjmOAGLHrsfZhdCYR0PvoIh706KAf4xX62OouwufjPkO_v98t54vs4deP-_m3h8xwUcis1ZSLkmtujGjKtrKcC9pCI-vSMMtYwzU0heW6NEJYYmklJS0TR7StmeVshrKDb9zBsGnUENxahzfltVNH6iUhUIKLOv1-hm4O-iH41w3EUa38JvTpiYrKgsqaSzm5VgeVCT7GAO3JlxI1FaFWaspYTXmrqQj1rwi1T6PXxws2zRrsafA9-ST4ehDsXAdv_22sfi4XE2J_ATX2mJU</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>HOLLESTELLE, M. J.</creator><creator>LOOTS, C. M.</creator><creator>SQUIZZATO, A.</creator><creator>RENNÉ, T.</creator><creator>BOUMA, B. J.</creator><creator>DE GROOT, P. G.</creator><creator>LENTING, P. J.</creator><creator>MEIJERS, J. C. M.</creator><creator>GERDES, V. E. A.</creator><general>Blackwell Publishing Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>201105</creationdate><title>Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients</title><author>HOLLESTELLE, M. J. ; LOOTS, C. M. ; SQUIZZATO, A. ; RENNÉ, T. ; BOUMA, B. J. ; DE GROOT, P. G. ; LENTING, P. J. ; MEIJERS, J. C. M. ; GERDES, V. E. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4527-fa14564a4cc5b6f8d4451feb796c3d33b4aeb2d4a6c55d0d187716aeb0ad93d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ADAM Proteins - blood</topic><topic>ADAMTS13 Protein</topic><topic>Aged</topic><topic>Antigens</topic><topic>aortic stenosis</topic><topic>Aortic Valve Stenosis - blood</topic><topic>Aortic Valve Stenosis - pathology</topic><topic>Cardiology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Hemorrhage</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptides - chemistry</topic><topic>platelet</topic><topic>Platelet Function Tests</topic><topic>Shear Strength</topic><topic>Stress, Mechanical</topic><topic>Surveys and Questionnaires</topic><topic>von Willebrand factor</topic><topic>von Willebrand Factor - biosynthesis</topic><topic>von Willebrand factor propeptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOLLESTELLE, M. J.</creatorcontrib><creatorcontrib>LOOTS, C. M.</creatorcontrib><creatorcontrib>SQUIZZATO, A.</creatorcontrib><creatorcontrib>RENNÉ, T.</creatorcontrib><creatorcontrib>BOUMA, B. J.</creatorcontrib><creatorcontrib>DE GROOT, P. G.</creatorcontrib><creatorcontrib>LENTING, P. J.</creatorcontrib><creatorcontrib>MEIJERS, J. C. M.</creatorcontrib><creatorcontrib>GERDES, V. E. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>JOURNAL OF THROMBOSIS AND HAEMOSTASIS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOLLESTELLE, M. J.</au><au>LOOTS, C. M.</au><au>SQUIZZATO, A.</au><au>RENNÉ, T.</au><au>BOUMA, B. J.</au><au>DE GROOT, P. G.</au><au>LENTING, P. J.</au><au>MEIJERS, J. C. M.</au><au>GERDES, V. E. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients</atitle><jtitle>JOURNAL OF THROMBOSIS AND HAEMOSTASIS</jtitle><addtitle>J Thromb Haemost</addtitle><date>2011-05</date><risdate>2011</risdate><volume>9</volume><issue>5</issue><spage>953</spage><epage>958</epage><pages>953-958</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>Background: Aortic stenosis patients often show bleeding complications. Previously, a prolonged platelet function analyzer (PFA‐100) closure time was observed with plasma of severe aortic stenosis patients. To elucidate a possible role of circulating preactivated von Willebrand factor (VWF), we determined the level of VWF in its active, platelet‐binding conformation in plasma of patients with aortic stenosis. Patients/methods: Sixty‐two aortic stenosis patients were included in this study. VWF and related parameters were measured, and the results were related to severity of aortic stenosis. Results: VWF activation factor, indicating the proportion of circulating VWF able to bind to platelets, correlated negatively with peak transvalvular gradient and PFA‐100 closure time. No correlation was observed between ADAMTS13 activity and peak transvalvular gradient or PFA‐100 closure time. Both VWF antigen and VWF propeptide levels were significantly higher in patients with mild and moderate aortic stenosis, but not in those with severe stenosis. Conclusions: Our data demonstrate that the aortic pressure gradient is inversely associated with VWF activation factor, but not with VWF antigen or VWF multimerization in patients with aortic stenosis. These findings might have implications for the bleeding observed in patients with aortic stenosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21352469</pmid><doi>10.1111/j.1538-7836.2011.04247.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1538-7933 |
| ispartof | JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011-05, Vol.9 (5), p.953-958 |
| issn | 1538-7933 1538-7836 1538-7836 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_545921 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | ADAM Proteins - blood ADAMTS13 Protein Aged Antigens aortic stenosis Aortic Valve Stenosis - blood Aortic Valve Stenosis - pathology Cardiology Electrocardiography Female Hemorrhage Hemostasis Humans Male Middle Aged Peptides - chemistry platelet Platelet Function Tests Shear Strength Stress, Mechanical Surveys and Questionnaires von Willebrand factor von Willebrand Factor - biosynthesis von Willebrand factor propeptide |
| title | Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T20%3A09%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20active%20von%20Willebrand%20factor%20level%20owing%20to%20shear%20stress%20in%20aortic%20stenosis%20patients&rft.jtitle=JOURNAL%20OF%20THROMBOSIS%20AND%20HAEMOSTASIS&rft.au=HOLLESTELLE,%20M.%20J.&rft.date=2011-05&rft.volume=9&rft.issue=5&rft.spage=953&rft.epage=958&rft.pages=953-958&rft.issn=1538-7933&rft.eissn=1538-7836&rft_id=info:doi/10.1111/j.1538-7836.2011.04247.x&rft_dat=%3Cproquest_swepu%3E3834850751%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1721794774&rft_id=info:pmid/21352469&rfr_iscdi=true |