Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients

Cancer pain patients need variable opioid doses. Preclinical and clinical studies suggest that opioid efficacy is related to genetic variability. However, the studies have small samples, findings are not replicated, and several candidate genes have not been studied. Therefore, a study of genetic var...

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Veröffentlicht in:	Pain (Amsterdam) 2011-05, Vol.152 (5), p.1139-1145
Hauptverfasser:	Klepstad, P., Fladvad, T., Skorpen, F., Bjordal, K., Caraceni, A., Dale, O., Davies, A., Kloke, M., Lundström, S., Maltoni, M., Radbruch, L., Sabatowski, R., Sigurdardottir, V., Strasser, F., Fayers, P.M., Kaasa, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Analgesics, Opioid - therapeutic use Biological and medical sciences Cancer Chi-Square Distribution Europe - epidemiology Female Fundamental and applied biological sciences. Psychology Genetic Genome-Wide Association Study Humans Illness and personality Illness, stress and coping Male Middle Aged Neoplasms - complications Opioid Opioid-Related Disorders - etiology Opioid-Related Disorders - genetics Pain Pain - drug therapy Pain - etiology Pain - genetics Pain Measurement Polymorphism Polymorphism, Single Nucleotide - genetics Psychology and medicine Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Opioid - genetics Signal Transduction - drug effects Signal Transduction - genetics Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs
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