Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

A cryo-EM structure of the bacterial ribosome–SecYEG complex in a so-called Nanodisc allows for the molecular interpretation of the SecYEG complex in its natural lipid bilayer environment. Molecular dynamics simulations based on the structure reveal stable interactions between ribosomal RNA and the...

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Veröffentlicht in:	NATURE STRUCTURAL & MOLECULAR BIOLOGY 2011-05, Vol.18 (5), p.614-621
Hauptverfasser:	Frauenfeld, Jens, Gumbart, James, Sluis, Eli O van der, Funes, Soledad, Gartmann, Marco, Beatrix, Birgitta, Mielke, Thorsten, Berninghausen, Otto, Becker, Thomas, Schulten, Klaus, Beckmann, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/574/1789 631/45/612/1237 631/535/1258/1259 Biochemistry Biological Microscopy Biomedical and Life Sciences Cell Membrane - metabolism Cryoelectron Microscopy Crystal structure Escherichia coli Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Life Sciences Lipids Lipoproteins, HDL - chemistry Lipoproteins, HDL - metabolism Medicin och hälsovetenskap Membrane Biology Membrane proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Models, Molecular Molecular biology Physiological aspects Polypeptides Protein Structure Protein Transport Proteins Ribonucleic acid Ribosomes Ribosomes - chemistry RNA SEC Translocation Channels Signal Recognition Particle - physiology Structure
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