Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax
Pfs230, surface protein of gametocyte/gamete of the human malaria parasite, Plasmodium falciparum, is a prime candidate of malaria transmission-blocking vaccine. Plasmodium vivax has an ortholog of Pfs230 (Pvs230), however, there has been no study in any aspects on Pvs230 to date. To investigate whe...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2011-06, Vol.29 (26), p.4308-4315 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4315 |
|---|---|
| container_issue | 26 |
| container_start_page | 4308 |
| container_title | Vaccine |
| container_volume | 29 |
| creator | Doi, Masanori Tanabe, Kazuyuki Tachibana, Shin-Ichiro Hamai, Meiko Tachibana, Mayumi Mita, Toshihiro Yagi, Masanori Zeyrek, Fadile Yildiz Ferreira, Marcelo U Ohmae, Hiroshi Kaneko, Akira Randrianarivelojosia, Milijaona Sattabongkot, Jetsumon Cao, Ya-Ming Horii, Toshihiro Torii, Motomi Tsuboi, Takafumi |
| description | Pfs230, surface protein of gametocyte/gamete of the human malaria parasite, Plasmodium falciparum, is a prime candidate of malaria transmission-blocking vaccine. Plasmodium vivax has an ortholog of Pfs230 (Pvs230), however, there has been no study in any aspects on Pvs230 to date. To investigate whether Pvs230 can be a vivax malaria transmission-blocking vaccine, we performed evolutionary and population genetic analysis of the Pvs230 gene (pvs230: PVX_003905). Our analysis of Pvs230 and its orthologs in eight Plasmodium species revealed two distinctive parts: an interspecies variable part (IVP) containing species-specific oligopeptide repeats at the N-terminus and a 7.5kb interspecies conserved part (ICP) containing 14 cysteine-rich domains. Pvs230 was closely related to its orthologs, Pks230 and Pcys230, in monkey malaria parasites. Analysis of 113 pvs230 sequences obtained from worldwide, showed that nucleotide diversity is remarkably low in the non-repeat 8-kb region of pvs230 (θπ=0.00118) with 77 polymorphic nucleotide sites, 40 of which results in amino acid replacements. A signature of purifying selection but not of balancing selection was seen on pvs230. Functional and/or structural constraints may limit the level of polymorphism in pvs230. The observed limited polymorphism in pvs230 should ground for utilization of Pvs230 as an effective transmission-blocking vaccine. |
| doi_str_mv | 10.1016/j.vaccine.2011.04.028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_544741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0264410X11005639</els_id><sourcerecordid>870553537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c782t-ea1afc7a1468b3642f8cab60facb330559ddcc927f0c8e188efc82c7348a3df33</originalsourceid><addsrcrecordid>eNqNk01v1DAQhiMEokvhJwC5ILhkGX8kcS5FVQUUaSUqlQpulteZbL2btbd2ktJ_j6MNLe0BOPnrGb_j8TtJ8pLAnAAp3q_ng9LaWJxTIGQOfA5UPEpmRJQsozkRj5MZ0IJnnMCPg-RZCGsAyBmpniYHlOSEM85nCX53vq2vTY1pwKsercZUOxvQD6ozzqauSTuvbNiaEOI6W7ZOb4xdpZN8qpWtTa06TM-GQBmkxqZnrQpbV5t-mw5mUD-fJ08a1QZ8MY2HycWnj99OTrPF189fTo4XmS4F7TJURDW6VIQXYskKThuh1bKARuklY5DnVV1rXdGyAS2QCIGNFlSXjAvF6oaxwyTb3xuucdcv5c6brfI30ikjp61NnKHMOS85ifzRno8nW6w12vjW9l7Y_RNrLuXKDZIRBgXAneDlg7DT44XcqdBh7yWAYHlRFcMo-HYS9C5WO3Qy1lVj2yqLrg9SxKwqwsv8P8hYD5azMpLv_kqSohQ5jS6hEc33qPYuBI_Nbc4E5GgruZbTv8rRVhK4jLaKca_-rNNt1G8fReDNBKigVdtEx2gT7jhOC6Awcq_3XKOcVCsfmYvzqJQDEE4EHV_zYU9g9Mlg0MugzWjL2njUnayd-WeyRw9u0K2xJqa1wRsMa9d7G00oiQxUgjwfu2RsEkJifxSsYr8AUEYOaA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1678522012</pqid></control><display><type>article</type><title>Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>SWEPUB Freely available online</source><creator>Doi, Masanori ; Tanabe, Kazuyuki ; Tachibana, Shin-Ichiro ; Hamai, Meiko ; Tachibana, Mayumi ; Mita, Toshihiro ; Yagi, Masanori ; Zeyrek, Fadile Yildiz ; Ferreira, Marcelo U ; Ohmae, Hiroshi ; Kaneko, Akira ; Randrianarivelojosia, Milijaona ; Sattabongkot, Jetsumon ; Cao, Ya-Ming ; Horii, Toshihiro ; Torii, Motomi ; Tsuboi, Takafumi</creator><creatorcontrib>Doi, Masanori ; Tanabe, Kazuyuki ; Tachibana, Shin-Ichiro ; Hamai, Meiko ; Tachibana, Mayumi ; Mita, Toshihiro ; Yagi, Masanori ; Zeyrek, Fadile Yildiz ; Ferreira, Marcelo U ; Ohmae, Hiroshi ; Kaneko, Akira ; Randrianarivelojosia, Milijaona ; Sattabongkot, Jetsumon ; Cao, Ya-Ming ; Horii, Toshihiro ; Torii, Motomi ; Tsuboi, Takafumi</creatorcontrib><description>Pfs230, surface protein of gametocyte/gamete of the human malaria parasite, Plasmodium falciparum, is a prime candidate of malaria transmission-blocking vaccine. Plasmodium vivax has an ortholog of Pfs230 (Pvs230), however, there has been no study in any aspects on Pvs230 to date. To investigate whether Pvs230 can be a vivax malaria transmission-blocking vaccine, we performed evolutionary and population genetic analysis of the Pvs230 gene (pvs230: PVX_003905). Our analysis of Pvs230 and its orthologs in eight Plasmodium species revealed two distinctive parts: an interspecies variable part (IVP) containing species-specific oligopeptide repeats at the N-terminus and a 7.5kb interspecies conserved part (ICP) containing 14 cysteine-rich domains. Pvs230 was closely related to its orthologs, Pks230 and Pcys230, in monkey malaria parasites. Analysis of 113 pvs230 sequences obtained from worldwide, showed that nucleotide diversity is remarkably low in the non-repeat 8-kb region of pvs230 (θπ=0.00118) with 77 polymorphic nucleotide sites, 40 of which results in amino acid replacements. A signature of purifying selection but not of balancing selection was seen on pvs230. Functional and/or structural constraints may limit the level of polymorphism in pvs230. The observed limited polymorphism in pvs230 should ground for utilization of Pvs230 as an effective transmission-blocking vaccine.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>EISSN: 0264-410X</identifier><identifier>DOI: 10.1016/j.vaccine.2011.04.028</identifier><identifier>PMID: 21514344</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Amino Acid Sequence ; amino acids ; Animals ; Antigens, Protozoan ; Antigens, Protozoan - chemistry ; Antigens, Protozoan - genetics ; Antigens, Protozoan - immunology ; Applied microbiology ; Biological and medical sciences ; Conserved Sequence ; DNA, Protozoan ; DNA, Protozoan - analysis ; Fundamental and applied biological sciences. Psychology ; Gametocyte surface antigen ; genes ; genetic techniques and protocols ; Human protozoal diseases ; Humans ; Infectious diseases ; Life Sciences ; Malaria ; Malaria Vaccines ; Malaria Vaccines - chemistry ; Malaria Vaccines - genetics ; Malaria Vaccines - immunology ; Malaria, Vivax ; Malaria, Vivax - parasitology ; Malaria, Vivax - prevention & control ; Malaria, Vivax - transmission ; Medical sciences ; Microbiology ; Molecular Sequence Data ; monkeys ; parasites ; Parasitic diseases ; Phylogeny ; Plasmodium falciparum ; Plasmodium vivax ; Plasmodium vivax - immunology ; Protozoal diseases ; Protozoan Proteins ; Protozoan Proteins - chemistry ; Protozoan Proteins - genetics ; Protozoan Proteins - immunology ; Purifying selection ; Pvs230 ; Sequence Alignment ; Sequence Analysis, DNA ; surface proteins ; Transmission-blocking vaccine ; vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2011-06, Vol.29 (26), p.4308-4315</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2011 Elsevier Ltd. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c782t-ea1afc7a1468b3642f8cab60facb330559ddcc927f0c8e188efc82c7348a3df33</citedby><cites>FETCH-LOGICAL-c782t-ea1afc7a1468b3642f8cab60facb330559ddcc927f0c8e188efc82c7348a3df33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X11005639$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24260204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21514344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://riip.hal.science/pasteur-00835696$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122873926$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Doi, Masanori</creatorcontrib><creatorcontrib>Tanabe, Kazuyuki</creatorcontrib><creatorcontrib>Tachibana, Shin-Ichiro</creatorcontrib><creatorcontrib>Hamai, Meiko</creatorcontrib><creatorcontrib>Tachibana, Mayumi</creatorcontrib><creatorcontrib>Mita, Toshihiro</creatorcontrib><creatorcontrib>Yagi, Masanori</creatorcontrib><creatorcontrib>Zeyrek, Fadile Yildiz</creatorcontrib><creatorcontrib>Ferreira, Marcelo U</creatorcontrib><creatorcontrib>Ohmae, Hiroshi</creatorcontrib><creatorcontrib>Kaneko, Akira</creatorcontrib><creatorcontrib>Randrianarivelojosia, Milijaona</creatorcontrib><creatorcontrib>Sattabongkot, Jetsumon</creatorcontrib><creatorcontrib>Cao, Ya-Ming</creatorcontrib><creatorcontrib>Horii, Toshihiro</creatorcontrib><creatorcontrib>Torii, Motomi</creatorcontrib><creatorcontrib>Tsuboi, Takafumi</creatorcontrib><title>Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Pfs230, surface protein of gametocyte/gamete of the human malaria parasite, Plasmodium falciparum, is a prime candidate of malaria transmission-blocking vaccine. Plasmodium vivax has an ortholog of Pfs230 (Pvs230), however, there has been no study in any aspects on Pvs230 to date. To investigate whether Pvs230 can be a vivax malaria transmission-blocking vaccine, we performed evolutionary and population genetic analysis of the Pvs230 gene (pvs230: PVX_003905). Our analysis of Pvs230 and its orthologs in eight Plasmodium species revealed two distinctive parts: an interspecies variable part (IVP) containing species-specific oligopeptide repeats at the N-terminus and a 7.5kb interspecies conserved part (ICP) containing 14 cysteine-rich domains. Pvs230 was closely related to its orthologs, Pks230 and Pcys230, in monkey malaria parasites. Analysis of 113 pvs230 sequences obtained from worldwide, showed that nucleotide diversity is remarkably low in the non-repeat 8-kb region of pvs230 (θπ=0.00118) with 77 polymorphic nucleotide sites, 40 of which results in amino acid replacements. A signature of purifying selection but not of balancing selection was seen on pvs230. Functional and/or structural constraints may limit the level of polymorphism in pvs230. The observed limited polymorphism in pvs230 should ground for utilization of Pvs230 as an effective transmission-blocking vaccine.</description><subject>Allergy and Immunology</subject><subject>Amino Acid Sequence</subject><subject>amino acids</subject><subject>Animals</subject><subject>Antigens, Protozoan</subject><subject>Antigens, Protozoan - chemistry</subject><subject>Antigens, Protozoan - genetics</subject><subject>Antigens, Protozoan - immunology</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Conserved Sequence</subject><subject>DNA, Protozoan</subject><subject>DNA, Protozoan - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gametocyte surface antigen</subject><subject>genes</subject><subject>genetic techniques and protocols</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Malaria</subject><subject>Malaria Vaccines</subject><subject>Malaria Vaccines - chemistry</subject><subject>Malaria Vaccines - genetics</subject><subject>Malaria Vaccines - immunology</subject><subject>Malaria, Vivax</subject><subject>Malaria, Vivax - parasitology</subject><subject>Malaria, Vivax - prevention & control</subject><subject>Malaria, Vivax - transmission</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>monkeys</subject><subject>parasites</subject><subject>Parasitic diseases</subject><subject>Phylogeny</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium vivax</subject><subject>Plasmodium vivax - immunology</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins</subject><subject>Protozoan Proteins - chemistry</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - immunology</subject><subject>Purifying selection</subject><subject>Pvs230</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>surface proteins</subject><subject>Transmission-blocking vaccine</subject><subject>vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><issn>0264-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNk01v1DAQhiMEokvhJwC5ILhkGX8kcS5FVQUUaSUqlQpulteZbL2btbd2ktJ_j6MNLe0BOPnrGb_j8TtJ8pLAnAAp3q_ng9LaWJxTIGQOfA5UPEpmRJQsozkRj5MZ0IJnnMCPg-RZCGsAyBmpniYHlOSEM85nCX53vq2vTY1pwKsercZUOxvQD6ozzqauSTuvbNiaEOI6W7ZOb4xdpZN8qpWtTa06TM-GQBmkxqZnrQpbV5t-mw5mUD-fJ08a1QZ8MY2HycWnj99OTrPF189fTo4XmS4F7TJURDW6VIQXYskKThuh1bKARuklY5DnVV1rXdGyAS2QCIGNFlSXjAvF6oaxwyTb3xuucdcv5c6brfI30ikjp61NnKHMOS85ifzRno8nW6w12vjW9l7Y_RNrLuXKDZIRBgXAneDlg7DT44XcqdBh7yWAYHlRFcMo-HYS9C5WO3Qy1lVj2yqLrg9SxKwqwsv8P8hYD5azMpLv_kqSohQ5jS6hEc33qPYuBI_Nbc4E5GgruZbTv8rRVhK4jLaKca_-rNNt1G8fReDNBKigVdtEx2gT7jhOC6Awcq_3XKOcVCsfmYvzqJQDEE4EHV_zYU9g9Mlg0MugzWjL2njUnayd-WeyRw9u0K2xJqa1wRsMa9d7G00oiQxUgjwfu2RsEkJifxSsYr8AUEYOaA</recordid><startdate>20110610</startdate><enddate>20110610</enddate><creator>Doi, Masanori</creator><creator>Tanabe, Kazuyuki</creator><creator>Tachibana, Shin-Ichiro</creator><creator>Hamai, Meiko</creator><creator>Tachibana, Mayumi</creator><creator>Mita, Toshihiro</creator><creator>Yagi, Masanori</creator><creator>Zeyrek, Fadile Yildiz</creator><creator>Ferreira, Marcelo U</creator><creator>Ohmae, Hiroshi</creator><creator>Kaneko, Akira</creator><creator>Randrianarivelojosia, Milijaona</creator><creator>Sattabongkot, Jetsumon</creator><creator>Cao, Ya-Ming</creator><creator>Horii, Toshihiro</creator><creator>Torii, Motomi</creator><creator>Tsuboi, Takafumi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>7T5</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20110610</creationdate><title>Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax</title><author>Doi, Masanori ; Tanabe, Kazuyuki ; Tachibana, Shin-Ichiro ; Hamai, Meiko ; Tachibana, Mayumi ; Mita, Toshihiro ; Yagi, Masanori ; Zeyrek, Fadile Yildiz ; Ferreira, Marcelo U ; Ohmae, Hiroshi ; Kaneko, Akira ; Randrianarivelojosia, Milijaona ; Sattabongkot, Jetsumon ; Cao, Ya-Ming ; Horii, Toshihiro ; Torii, Motomi ; Tsuboi, Takafumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c782t-ea1afc7a1468b3642f8cab60facb330559ddcc927f0c8e188efc82c7348a3df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Allergy and Immunology</topic><topic>Amino Acid Sequence</topic><topic>amino acids</topic><topic>Animals</topic><topic>Antigens, Protozoan</topic><topic>Antigens, Protozoan - chemistry</topic><topic>Antigens, Protozoan - genetics</topic><topic>Antigens, Protozoan - immunology</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Conserved Sequence</topic><topic>DNA, Protozoan</topic><topic>DNA, Protozoan - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gametocyte surface antigen</topic><topic>genes</topic><topic>genetic techniques and protocols</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><topic>Malaria</topic><topic>Malaria Vaccines</topic><topic>Malaria Vaccines - chemistry</topic><topic>Malaria Vaccines - genetics</topic><topic>Malaria Vaccines - immunology</topic><topic>Malaria, Vivax</topic><topic>Malaria, Vivax - parasitology</topic><topic>Malaria, Vivax - prevention & control</topic><topic>Malaria, Vivax - transmission</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>monkeys</topic><topic>parasites</topic><topic>Parasitic diseases</topic><topic>Phylogeny</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium vivax</topic><topic>Plasmodium vivax - immunology</topic><topic>Protozoal diseases</topic><topic>Protozoan Proteins</topic><topic>Protozoan Proteins - chemistry</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - immunology</topic><topic>Purifying selection</topic><topic>Pvs230</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>surface proteins</topic><topic>Transmission-blocking vaccine</topic><topic>vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doi, Masanori</creatorcontrib><creatorcontrib>Tanabe, Kazuyuki</creatorcontrib><creatorcontrib>Tachibana, Shin-Ichiro</creatorcontrib><creatorcontrib>Hamai, Meiko</creatorcontrib><creatorcontrib>Tachibana, Mayumi</creatorcontrib><creatorcontrib>Mita, Toshihiro</creatorcontrib><creatorcontrib>Yagi, Masanori</creatorcontrib><creatorcontrib>Zeyrek, Fadile Yildiz</creatorcontrib><creatorcontrib>Ferreira, Marcelo U</creatorcontrib><creatorcontrib>Ohmae, Hiroshi</creatorcontrib><creatorcontrib>Kaneko, Akira</creatorcontrib><creatorcontrib>Randrianarivelojosia, Milijaona</creatorcontrib><creatorcontrib>Sattabongkot, Jetsumon</creatorcontrib><creatorcontrib>Cao, Ya-Ming</creatorcontrib><creatorcontrib>Horii, Toshihiro</creatorcontrib><creatorcontrib>Torii, Motomi</creatorcontrib><creatorcontrib>Tsuboi, Takafumi</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doi, Masanori</au><au>Tanabe, Kazuyuki</au><au>Tachibana, Shin-Ichiro</au><au>Hamai, Meiko</au><au>Tachibana, Mayumi</au><au>Mita, Toshihiro</au><au>Yagi, Masanori</au><au>Zeyrek, Fadile Yildiz</au><au>Ferreira, Marcelo U</au><au>Ohmae, Hiroshi</au><au>Kaneko, Akira</au><au>Randrianarivelojosia, Milijaona</au><au>Sattabongkot, Jetsumon</au><au>Cao, Ya-Ming</au><au>Horii, Toshihiro</au><au>Torii, Motomi</au><au>Tsuboi, Takafumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2011-06-10</date><risdate>2011</risdate><volume>29</volume><issue>26</issue><spage>4308</spage><epage>4315</epage><pages>4308-4315</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><eissn>0264-410X</eissn><coden>VACCDE</coden><abstract>Pfs230, surface protein of gametocyte/gamete of the human malaria parasite, Plasmodium falciparum, is a prime candidate of malaria transmission-blocking vaccine. Plasmodium vivax has an ortholog of Pfs230 (Pvs230), however, there has been no study in any aspects on Pvs230 to date. To investigate whether Pvs230 can be a vivax malaria transmission-blocking vaccine, we performed evolutionary and population genetic analysis of the Pvs230 gene (pvs230: PVX_003905). Our analysis of Pvs230 and its orthologs in eight Plasmodium species revealed two distinctive parts: an interspecies variable part (IVP) containing species-specific oligopeptide repeats at the N-terminus and a 7.5kb interspecies conserved part (ICP) containing 14 cysteine-rich domains. Pvs230 was closely related to its orthologs, Pks230 and Pcys230, in monkey malaria parasites. Analysis of 113 pvs230 sequences obtained from worldwide, showed that nucleotide diversity is remarkably low in the non-repeat 8-kb region of pvs230 (θπ=0.00118) with 77 polymorphic nucleotide sites, 40 of which results in amino acid replacements. A signature of purifying selection but not of balancing selection was seen on pvs230. Functional and/or structural constraints may limit the level of polymorphism in pvs230. The observed limited polymorphism in pvs230 should ground for utilization of Pvs230 as an effective transmission-blocking vaccine.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21514344</pmid><doi>10.1016/j.vaccine.2011.04.028</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2011-06, Vol.29 (26), p.4308-4315 |
| issn | 0264-410X 1873-2518 0264-410X |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_544741 |
| source | MEDLINE; Elsevier ScienceDirect Journals; SWEPUB Freely available online |
| subjects | Allergy and Immunology Amino Acid Sequence amino acids Animals Antigens, Protozoan Antigens, Protozoan - chemistry Antigens, Protozoan - genetics Antigens, Protozoan - immunology Applied microbiology Biological and medical sciences Conserved Sequence DNA, Protozoan DNA, Protozoan - analysis Fundamental and applied biological sciences. Psychology Gametocyte surface antigen genes genetic techniques and protocols Human protozoal diseases Humans Infectious diseases Life Sciences Malaria Malaria Vaccines Malaria Vaccines - chemistry Malaria Vaccines - genetics Malaria Vaccines - immunology Malaria, Vivax Malaria, Vivax - parasitology Malaria, Vivax - prevention & control Malaria, Vivax - transmission Medical sciences Microbiology Molecular Sequence Data monkeys parasites Parasitic diseases Phylogeny Plasmodium falciparum Plasmodium vivax Plasmodium vivax - immunology Protozoal diseases Protozoan Proteins Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - immunology Purifying selection Pvs230 Sequence Alignment Sequence Analysis, DNA surface proteins Transmission-blocking vaccine vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T22%3A16%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Worldwide%20sequence%20conservation%20of%20transmission-blocking%20vaccine%20candidate%20Pvs230%20in%20Plasmodium%20vivax&rft.jtitle=Vaccine&rft.au=Doi,%20Masanori&rft.date=2011-06-10&rft.volume=29&rft.issue=26&rft.spage=4308&rft.epage=4315&rft.pages=4308-4315&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/j.vaccine.2011.04.028&rft_dat=%3Cproquest_swepu%3E870553537%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1678522012&rft_id=info:pmid/21514344&rft_els_id=1_s2_0_S0264410X11005639&rfr_iscdi=true |