Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort
Abstract The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (L...
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| Veröffentlicht in: | Journal of the neurological sciences 2011-08, Vol.307 (1), p.100-105 |
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| creator | Ryberg, C Rostrup, E Paulson, O.B Barkhof, F Scheltens, P van Straaten, E.C.W van der Flier, W.M Fazekas, F Schmidt, R Ferro, J.M Baezner, H Erkinjuntti, T Jokinen, H Wahlund, L.-O Poggesi, A Pantoni, L Inzitari, D Waldemar, G |
| description | Abstract The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior–posterior regions (CC1–CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p < 0.01 for CC1, p < 0.05 for CC5), motor function (p < 0.05 for CC2 and CC5), and walking speed (p < 0.01 for CC2 and CC5, p < 0.05 for CC3 and total CC), and with development of dementia at 3 years (p < 0.05 for CC1) after correction for appropriate confounders (ARWMC volume, atrophy, age, gender and handedness). In conclusion, CC atrophy, an indicator of reduced functional connectivity between cortical areas, seems to contribute, independently of ARWMC load, to future cognitive and motor decline in the elderly. |
| doi_str_mv | 10.1016/j.jns.2011.05.002 |
| format | Article |
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On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior–posterior regions (CC1–CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p < 0.01 for CC1, p < 0.05 for CC5), motor function (p < 0.05 for CC2 and CC5), and walking speed (p < 0.01 for CC2 and CC5, p < 0.05 for CC3 and total CC), and with development of dementia at 3 years (p < 0.05 for CC1) after correction for appropriate confounders (ARWMC volume, atrophy, age, gender and handedness). In conclusion, CC atrophy, an indicator of reduced functional connectivity between cortical areas, seems to contribute, independently of ARWMC load, to future cognitive and motor decline in the elderly.]]></description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2011.05.002</identifier><identifier>PMID: 21621224</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Age-related white matter ; Aged ; Aging - pathology ; Aging - physiology ; Atrophy ; Biological and medical sciences ; changes ; Cognition ; Cognition Disorders - pathology ; Cognition Disorders - physiopathology ; Cohort Studies ; Corpus callosum ; Corpus Callosum - pathology ; Corpus Callosum - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Elderly ; Female ; Follow-Up Studies ; Follow-up study ; Humans ; LADIS ; Male ; Medical sciences ; Memory Disorders - pathology ; Memory Disorders - physiopathology ; Motor function ; Neurology ; Psychomotor Disorders - pathology ; Psychomotor Disorders - physiopathology ; Walking - physiology</subject><ispartof>Journal of the neurological sciences, 2011-08, Vol.307 (1), p.100-105</ispartof><rights>Elsevier B.V.</rights><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-21b662e8debf2589a1003f2e6f3e43040795b62475d00a640dfe1e05a01d76f43</citedby><cites>FETCH-LOGICAL-c507t-21b662e8debf2589a1003f2e6f3e43040795b62475d00a640dfe1e05a01d76f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022510X11002334$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24314122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21621224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122997068$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryberg, C</creatorcontrib><creatorcontrib>Rostrup, E</creatorcontrib><creatorcontrib>Paulson, O.B</creatorcontrib><creatorcontrib>Barkhof, F</creatorcontrib><creatorcontrib>Scheltens, P</creatorcontrib><creatorcontrib>van Straaten, E.C.W</creatorcontrib><creatorcontrib>van der Flier, W.M</creatorcontrib><creatorcontrib>Fazekas, F</creatorcontrib><creatorcontrib>Schmidt, R</creatorcontrib><creatorcontrib>Ferro, J.M</creatorcontrib><creatorcontrib>Baezner, H</creatorcontrib><creatorcontrib>Erkinjuntti, T</creatorcontrib><creatorcontrib>Jokinen, H</creatorcontrib><creatorcontrib>Wahlund, L.-O</creatorcontrib><creatorcontrib>Poggesi, A</creatorcontrib><creatorcontrib>Pantoni, L</creatorcontrib><creatorcontrib>Inzitari, D</creatorcontrib><creatorcontrib>Waldemar, G</creatorcontrib><creatorcontrib>on behalf of the LADIS study group</creatorcontrib><creatorcontrib>LADIS study group</creatorcontrib><title>Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description><![CDATA[Abstract The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior–posterior regions (CC1–CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p < 0.01 for CC1, p < 0.05 for CC5), motor function (p < 0.05 for CC2 and CC5), and walking speed (p < 0.01 for CC2 and CC5, p < 0.05 for CC3 and total CC), and with development of dementia at 3 years (p < 0.05 for CC1) after correction for appropriate confounders (ARWMC volume, atrophy, age, gender and handedness). In conclusion, CC atrophy, an indicator of reduced functional connectivity between cortical areas, seems to contribute, independently of ARWMC load, to future cognitive and motor decline in the elderly.]]></description><subject>Age-related white matter</subject><subject>Aged</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>changes</subject><subject>Cognition</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cohort Studies</subject><subject>Corpus callosum</subject><subject>Corpus Callosum - pathology</subject><subject>Corpus Callosum - physiopathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Elderly</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Follow-up study</subject><subject>Humans</subject><subject>LADIS</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - pathology</subject><subject>Memory Disorders - physiopathology</subject><subject>Motor function</subject><subject>Neurology</subject><subject>Psychomotor Disorders - pathology</subject><subject>Psychomotor Disorders - physiopathology</subject><subject>Walking - physiology</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkGL1DAUx4so7rj6AbxILuKp43tJ2skoCMO46sKAh1XwFjLp605m26Ym7S5z9ZNvyowreBAhkPD4vX8e-SXLXiLMEbB8u5_vuzjngDiHYg7AH2UzVAuVF0qJx9ksVXheIPw4y57FuAeAUqnl0-yMY8mRcznLfq196MfIrGkaH8eWmSH4fndgJjLD-kCVs4MPzNfMXFMeqDEDVcz6684N7paY6SrW-glxbW9caKkb3rEVE_mBTGC1T7l3-dhPCcOO2Gb18fKKxWGsDill58PwPHtSmybSi9N-nn3_dPFt_SXffP18uV5tclvAYsg5bsuSk6poW_NCLQ0CiJpTWQuSAiQslsW25HJRVACmlFDVhASFAawWZS3FeZYfc-Md9eNW98G1Jhy0N06fSjfpRLqQEhAS_-bI98H_HCkOunXRUtOYjvwYtVJScoGl-g9SAC7TSiQeSRt8jIHqhykQ9ORU73VyqienGgqdDKaeV6f0cdtS9dDxW2ICXp8AE5PHOpjOuviHkwJlAhP3_shReuVbR0FH66izyXEgO-jKu3-O8eGvbtu4zqULb-hAce_H0CV9GnXkGvTV9Pmmv4c4dQsp7gE3oNOA</recordid><startdate>20110815</startdate><enddate>20110815</enddate><creator>Ryberg, C</creator><creator>Rostrup, E</creator><creator>Paulson, O.B</creator><creator>Barkhof, F</creator><creator>Scheltens, P</creator><creator>van Straaten, E.C.W</creator><creator>van der Flier, W.M</creator><creator>Fazekas, F</creator><creator>Schmidt, R</creator><creator>Ferro, J.M</creator><creator>Baezner, H</creator><creator>Erkinjuntti, T</creator><creator>Jokinen, H</creator><creator>Wahlund, L.-O</creator><creator>Poggesi, A</creator><creator>Pantoni, L</creator><creator>Inzitari, D</creator><creator>Waldemar, G</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20110815</creationdate><title>Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort</title><author>Ryberg, C ; Rostrup, E ; Paulson, O.B ; Barkhof, F ; Scheltens, P ; van Straaten, E.C.W ; van der Flier, W.M ; Fazekas, F ; Schmidt, R ; Ferro, J.M ; Baezner, H ; Erkinjuntti, T ; Jokinen, H ; Wahlund, L.-O ; Poggesi, A ; Pantoni, L ; Inzitari, D ; Waldemar, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-21b662e8debf2589a1003f2e6f3e43040795b62475d00a640dfe1e05a01d76f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age-related white matter</topic><topic>Aged</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>changes</topic><topic>Cognition</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cohort Studies</topic><topic>Corpus callosum</topic><topic>Corpus Callosum - pathology</topic><topic>Corpus Callosum - physiopathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>Elderly</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Follow-up study</topic><topic>Humans</topic><topic>LADIS</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - pathology</topic><topic>Memory Disorders - physiopathology</topic><topic>Motor function</topic><topic>Neurology</topic><topic>Psychomotor Disorders - pathology</topic><topic>Psychomotor Disorders - physiopathology</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryberg, C</creatorcontrib><creatorcontrib>Rostrup, E</creatorcontrib><creatorcontrib>Paulson, O.B</creatorcontrib><creatorcontrib>Barkhof, F</creatorcontrib><creatorcontrib>Scheltens, P</creatorcontrib><creatorcontrib>van Straaten, E.C.W</creatorcontrib><creatorcontrib>van der Flier, W.M</creatorcontrib><creatorcontrib>Fazekas, F</creatorcontrib><creatorcontrib>Schmidt, R</creatorcontrib><creatorcontrib>Ferro, J.M</creatorcontrib><creatorcontrib>Baezner, H</creatorcontrib><creatorcontrib>Erkinjuntti, T</creatorcontrib><creatorcontrib>Jokinen, H</creatorcontrib><creatorcontrib>Wahlund, L.-O</creatorcontrib><creatorcontrib>Poggesi, A</creatorcontrib><creatorcontrib>Pantoni, L</creatorcontrib><creatorcontrib>Inzitari, D</creatorcontrib><creatorcontrib>Waldemar, G</creatorcontrib><creatorcontrib>on behalf of the LADIS study group</creatorcontrib><creatorcontrib>LADIS study group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryberg, C</au><au>Rostrup, E</au><au>Paulson, O.B</au><au>Barkhof, F</au><au>Scheltens, P</au><au>van Straaten, E.C.W</au><au>van der Flier, W.M</au><au>Fazekas, F</au><au>Schmidt, R</au><au>Ferro, J.M</au><au>Baezner, H</au><au>Erkinjuntti, T</au><au>Jokinen, H</au><au>Wahlund, L.-O</au><au>Poggesi, A</au><au>Pantoni, L</au><au>Inzitari, D</au><au>Waldemar, G</au><aucorp>on behalf of the LADIS study group</aucorp><aucorp>LADIS study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2011-08-15</date><risdate>2011</risdate><volume>307</volume><issue>1</issue><spage>100</spage><epage>105</epage><pages>100-105</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract><![CDATA[Abstract The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior–posterior regions (CC1–CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p < 0.01 for CC1, p < 0.05 for CC5), motor function (p < 0.05 for CC2 and CC5), and walking speed (p < 0.01 for CC2 and CC5, p < 0.05 for CC3 and total CC), and with development of dementia at 3 years (p < 0.05 for CC1) after correction for appropriate confounders (ARWMC volume, atrophy, age, gender and handedness). In conclusion, CC atrophy, an indicator of reduced functional connectivity between cortical areas, seems to contribute, independently of ARWMC load, to future cognitive and motor decline in the elderly.]]></abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21621224</pmid><doi>10.1016/j.jns.2011.05.002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of the neurological sciences, 2011-08, Vol.307 (1), p.100-105 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age-related white matter Aged Aging - pathology Aging - physiology Atrophy Biological and medical sciences changes Cognition Cognition Disorders - pathology Cognition Disorders - physiopathology Cohort Studies Corpus callosum Corpus Callosum - pathology Corpus Callosum - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Elderly Female Follow-Up Studies Follow-up study Humans LADIS Male Medical sciences Memory Disorders - pathology Memory Disorders - physiopathology Motor function Neurology Psychomotor Disorders - pathology Psychomotor Disorders - physiopathology Walking - physiology |
| title | Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort |
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