Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats

Tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of asthma, and neutralization of TNF-α is an effective therapy for inflammatory diseases. The present study tested the idea that a TNF-α antibody, infliximab, may be useful in the management of asthma. E3 rats were immunized wit...

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Veröffentlicht in:	International immunology 2011-07, Vol.23 (7), p.443-451
Hauptverfasser:	Cai, Yan, Cao, Yong-Xiao, Lu, She-Min, Xu, Cang-Bao, Cardell, Lars Olaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annan klinisk medicin Anti-Asthmatic Agents - pharmacology Anti-Asthmatic Agents - therapeutic use Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Arginase - metabolism asthma Asthma - blood Asthma - drug therapy Asthma - pathology Bronchoalveolar Lavage Fluid - immunology Clinical Medicine cytokine Cytokines - blood Disease Models, Animal Eosinophils - drug effects Eosinophils - immunology Eosinophils - pathology Immunoglobulin E - blood inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Infliximab Klinisk medicin Lung - drug effects Lung - immunology Lung - metabolism Lung - pathology Male Medical and Health Sciences Medicin och hälsovetenskap Muscle, Smooth - drug effects Muscle, Smooth - immunology Nitric Oxide - blood Nitric Oxide Synthase - metabolism Other Clinical Medicine Rats receptor tumor necrosis factor-alpha
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