Stem cell-based therapy and regenerative approaches to diseases of the respiratory system
Despite treatment advances in many diseases of the respiratory system, outcome remains poor. This systematic review (PubMed and Ovid) 'analyses stem cell (SC)-based therapy and regenerative medicine (RM) approaches as potential novel strategies for diseases of the respiratory system. Current pr...
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| Veröffentlicht in: | British medical bulletin 2011, Vol.99 (1), p.169-187 |
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| creator | JUNGEBLUTH, Philipp MACCHIARINI, Paolo |
| description | Despite treatment advances in many diseases of the respiratory system, outcome remains poor.
This systematic review (PubMed and Ovid) 'analyses stem cell (SC)-based therapy and regenerative medicine (RM) approaches as potential novel strategies for diseases of the respiratory system. Current preclinical research and ongoing clinical trials are presented and their potential clinical impact and routine application discussed.
These approaches may represent a promising alternative therapy for otherwise irreversible respiratory diseases. Several experimental and initial clinical data now exist.
Type of SC, limits of tissue engineering, route of delivery, cell behaviour (differentiation, growth, co-stimulation or immunomodulation) and interaction with the human microenvironment upon implantation.
Investigating underlying pathways and mechanisms. Evaluating gene, epigenetic and protein regulation. Interaction with the environment under diseased and healthy conditions. Detecting approaches with significant scientific and clinical impact.
The potential capacity of SC-based therapy and RM should be carefully investigated before their translation into clinical practice. |
| doi_str_mv | 10.1093/bmb/ldr028 |
| format | Article |
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This systematic review (PubMed and Ovid) 'analyses stem cell (SC)-based therapy and regenerative medicine (RM) approaches as potential novel strategies for diseases of the respiratory system. Current preclinical research and ongoing clinical trials are presented and their potential clinical impact and routine application discussed.
These approaches may represent a promising alternative therapy for otherwise irreversible respiratory diseases. Several experimental and initial clinical data now exist.
Type of SC, limits of tissue engineering, route of delivery, cell behaviour (differentiation, growth, co-stimulation or immunomodulation) and interaction with the human microenvironment upon implantation.
Investigating underlying pathways and mechanisms. Evaluating gene, epigenetic and protein regulation. Interaction with the environment under diseased and healthy conditions. Detecting approaches with significant scientific and clinical impact.
The potential capacity of SC-based therapy and RM should be carefully investigated before their translation into clinical practice.</description><identifier>ISSN: 0007-1420</identifier><identifier>ISSN: 1471-8391</identifier><identifier>EISSN: 1471-8391</identifier><identifier>DOI: 10.1093/bmb/ldr028</identifier><identifier>PMID: 21725086</identifier><identifier>CODEN: BMBUAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Applied cell therapy and gene therapy ; Biological and medical sciences ; Cell Physiological Phenomena ; Clinical Trials as Topic ; General aspects ; Genetic Therapy - methods ; Genetic Therapy - trends ; Humans ; Medical sciences ; Medicin och hälsovetenskap ; Regeneration - physiology ; Regenerative Medicine - methods ; Regenerative Medicine - trends ; Respiratory Physiological Phenomena ; Respiratory System - pathology ; Respiratory System - physiopathology ; Respiratory Tract Diseases - pathology ; Respiratory Tract Diseases - physiopathology ; Respiratory Tract Diseases - therapy ; Stem Cell Research ; Stem Cell Transplantation - methods ; Stem Cell Transplantation - trends ; Tissue Engineering - methods ; Tissue Engineering - trends ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>British medical bulletin, 2011, Vol.99 (1), p.169-187</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-b73eaa4d5e5437de6e1a96d25c5ae312e8c5f776f1d1d283f35d59a9927e8a1b3</citedby><cites>FETCH-LOGICAL-c440t-b73eaa4d5e5437de6e1a96d25c5ae312e8c5f776f1d1d283f35d59a9927e8a1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24496525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21725086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:123226025$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>JUNGEBLUTH, Philipp</creatorcontrib><creatorcontrib>MACCHIARINI, Paolo</creatorcontrib><title>Stem cell-based therapy and regenerative approaches to diseases of the respiratory system</title><title>British medical bulletin</title><addtitle>Br Med Bull</addtitle><description>Despite treatment advances in many diseases of the respiratory system, outcome remains poor.
This systematic review (PubMed and Ovid) 'analyses stem cell (SC)-based therapy and regenerative medicine (RM) approaches as potential novel strategies for diseases of the respiratory system. Current preclinical research and ongoing clinical trials are presented and their potential clinical impact and routine application discussed.
These approaches may represent a promising alternative therapy for otherwise irreversible respiratory diseases. Several experimental and initial clinical data now exist.
Type of SC, limits of tissue engineering, route of delivery, cell behaviour (differentiation, growth, co-stimulation or immunomodulation) and interaction with the human microenvironment upon implantation.
Investigating underlying pathways and mechanisms. Evaluating gene, epigenetic and protein regulation. Interaction with the environment under diseased and healthy conditions. Detecting approaches with significant scientific and clinical impact.
The potential capacity of SC-based therapy and RM should be carefully investigated before their translation into clinical practice.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Applied cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cell Physiological Phenomena</subject><subject>Clinical Trials as Topic</subject><subject>General aspects</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Therapy - trends</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Regeneration - physiology</subject><subject>Regenerative Medicine - methods</subject><subject>Regenerative Medicine - trends</subject><subject>Respiratory Physiological Phenomena</subject><subject>Respiratory System - pathology</subject><subject>Respiratory System - physiopathology</subject><subject>Respiratory Tract Diseases - pathology</subject><subject>Respiratory Tract Diseases - physiopathology</subject><subject>Respiratory Tract Diseases - therapy</subject><subject>Stem Cell Research</subject><subject>Stem Cell Transplantation - methods</subject><subject>Stem Cell Transplantation - trends</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Engineering - trends</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0007-1420</issn><issn>1471-8391</issn><issn>1471-8391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAURi0EotPChh9QeYOQKoX6GdvLqgJaqRILYMHKuolvaGgySX0zRfPv8Wim7aorP3TO58fH2AcpPksR9HkzNudDykL5V2wljZOV10G-ZishhKukUeKIHRP9FUJqLfxbdqSkU1b4esV-_1hw5C0OQ9UAYeLLLWaYtxzWiWf8g-uyXPoH5DDPeYL2FokvE089YeGJT91OKSjNfSGnvOW0pRL6jr3pYCB8fxhP2K-vX35eXlU3379dX17cVK0xYqkapxHAJIvWaJewRgmhTsq2FlBLhb61nXN1J5NMyutO22QDhKAcepCNPmHVPpf-4bxp4pz7EfI2TtDHw9ZdmWEs-VrXhQ8v8uWF6Vl6FKXSStVC2eJ-2rsFvN8gLXHsafd5sMZpQ9F7F4zSIRTybE-2eSLK2D2dI0XctRZLa3HfWoFPD7GbZsT0hD7WVICPBwCohaHLsG57euaMCbUt9_sPTaCjNg</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>JUNGEBLUTH, Philipp</creator><creator>MACCHIARINI, Paolo</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>2011</creationdate><title>Stem cell-based therapy and regenerative approaches to diseases of the respiratory system</title><author>JUNGEBLUTH, Philipp ; MACCHIARINI, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-b73eaa4d5e5437de6e1a96d25c5ae312e8c5f776f1d1d283f35d59a9927e8a1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Applied cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cell Physiological Phenomena</topic><topic>Clinical Trials as Topic</topic><topic>General aspects</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Therapy - trends</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Regeneration - physiology</topic><topic>Regenerative Medicine - methods</topic><topic>Regenerative Medicine - trends</topic><topic>Respiratory Physiological Phenomena</topic><topic>Respiratory System - pathology</topic><topic>Respiratory System - physiopathology</topic><topic>Respiratory Tract Diseases - pathology</topic><topic>Respiratory Tract Diseases - physiopathology</topic><topic>Respiratory Tract Diseases - therapy</topic><topic>Stem Cell Research</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem Cell Transplantation - trends</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Engineering - trends</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JUNGEBLUTH, Philipp</creatorcontrib><creatorcontrib>MACCHIARINI, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>British medical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JUNGEBLUTH, Philipp</au><au>MACCHIARINI, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stem cell-based therapy and regenerative approaches to diseases of the respiratory system</atitle><jtitle>British medical bulletin</jtitle><addtitle>Br Med Bull</addtitle><date>2011</date><risdate>2011</risdate><volume>99</volume><issue>1</issue><spage>169</spage><epage>187</epage><pages>169-187</pages><issn>0007-1420</issn><issn>1471-8391</issn><eissn>1471-8391</eissn><coden>BMBUAQ</coden><abstract>Despite treatment advances in many diseases of the respiratory system, outcome remains poor.
This systematic review (PubMed and Ovid) 'analyses stem cell (SC)-based therapy and regenerative medicine (RM) approaches as potential novel strategies for diseases of the respiratory system. Current preclinical research and ongoing clinical trials are presented and their potential clinical impact and routine application discussed.
These approaches may represent a promising alternative therapy for otherwise irreversible respiratory diseases. Several experimental and initial clinical data now exist.
Type of SC, limits of tissue engineering, route of delivery, cell behaviour (differentiation, growth, co-stimulation or immunomodulation) and interaction with the human microenvironment upon implantation.
Investigating underlying pathways and mechanisms. Evaluating gene, epigenetic and protein regulation. Interaction with the environment under diseased and healthy conditions. Detecting approaches with significant scientific and clinical impact.
The potential capacity of SC-based therapy and RM should be carefully investigated before their translation into clinical practice.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21725086</pmid><doi>10.1093/bmb/ldr028</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Cell Physiological Phenomena Clinical Trials as Topic General aspects Genetic Therapy - methods Genetic Therapy - trends Humans Medical sciences Medicin och hälsovetenskap Regeneration - physiology Regenerative Medicine - methods Regenerative Medicine - trends Respiratory Physiological Phenomena Respiratory System - pathology Respiratory System - physiopathology Respiratory Tract Diseases - pathology Respiratory Tract Diseases - physiopathology Respiratory Tract Diseases - therapy Stem Cell Research Stem Cell Transplantation - methods Stem Cell Transplantation - trends Tissue Engineering - methods Tissue Engineering - trends Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Stem cell-based therapy and regenerative approaches to diseases of the respiratory system |
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