Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)

► YUH1 and UCH-L3 can truncate UBB+1 from its C-terminus. ► Hydrolysis of UBB+1 occurs after Y76 yielding a protein equal in length to ubiquitin. ► Biochemical properties of truncated UBB+1 are similar to full length UBB+1. ► Levels of UCH-L3 are unchanged in Alzheimer’s, Huntingtons’s and Parkinson...

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Veröffentlicht in:	FEBS letters 2011-08, Vol.585 (16), p.2568-2574
Hauptverfasser:	Dennissen, Frank J.A., Kholod, Natalia, Hermes, Denise J.H.P., Kemmerling, Nadja, Steinbusch, Harry W.M., Dantuma, Nico P., van Leeuwen, Fred W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Cysteine Endopeptidases - metabolism Endopeptidases - deficiency Endopeptidases - genetics HEK293 Cells HeLa Cells Humans Hydrolysis Mice Mutant Proteins - metabolism Neurodegenerative Diseases - genetics Oxidation-Reduction Saccharomyces cerevisiae Sequence Deletion UBB+1 Ubiquitin - deficiency Ubiquitin - genetics Ubiquitin - metabolism Ubiquitin C-terminal hydrolase L3 Yeast ubiquitin hydrolase 1
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