The different roles of ER subtypes in cancer biology and therapy

Key Points Oestrogen receptor (ER) subtypes (ERα and ERβ) influence the development and progression of hormone-related cancers by exerting distinct biological functions. ERα is associated with aberrant proliferation, inflammation and the development of malignancy. ERβ seems to oppose ERα actions on...

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Veröffentlicht in:	Nature reviews. Cancer 2011-08, Vol.11 (8), p.597-608
Hauptverfasser:	Thomas, Christoforos, Gustafsson, Jan-Åke
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/602 631/67/68 631/80/86/2363 Animals Biomedical and Life Sciences Biomedicine Breast cancer Cancer cells Cancer Research Care and treatment Development and progression Estrogen Estrogen Receptor alpha - physiology Estrogen Receptor beta - physiology Gene expression Genetic aspects Humans Neoplasms - drug therapy Neoplasms - physiopathology Physiological aspects Prognosis Protein Isoforms Receptors review-article
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