Synthesis and Characterization of a Series of Highly Fluorogenic Substrates for Glutathione Transferases, a General Strategy

Glutathione transferases (GSTs) are used in biotechnology applications as fusion partners for facile purification and are also overexpressed in certain tumors. Consequently, there is a need for sensitive detection of the enzymes. Here we describe a general strategy for the synthesis and characteriza...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2011-09, Vol.133 (35), p.14109-14119
Hauptverfasser:	Zhang, Jie, Shibata, Aya, Ito, Mika, Shuto, Satoshi, Ito, Yoshihiro, Mannervik, Bengt, Abe, Hiroshi, Morgenstern, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Glutathione Transferase - metabolism Humans Kinetics Medicin och hälsovetenskap Microscopy, Fluorescence Spectrometry, Fluorescence Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!