Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study
Background It has been hypothesized that children and adolescents might be more vulnerable to possible health effects from mobile phone exposure than adults. We investigated whether mobile phone use is associated with brain tumor risk among children and adolescents. Methods CEFALO is a multicenter c...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2011-08, Vol.103 (16), p.1264-1276 |
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| creator | Aydin, Denis Feychting, Maria Schüz, Joachim Tynes, Tore Andersen, Tina Veje Schmidt, Lisbeth Samsø Poulsen, Aslak Harbo Johansen, Christoffer Prochazka, Michaela Lannering, Birgitta Klæboe, Lars Eggen, Tone Jenni, Daniela Grotzer, Michael Von der Weid, Nicolas Kuehni, Claudia E. Röösli, Martin |
| description | Background
It has been hypothesized that children and adolescents might be more vulnerable to possible health effects from mobile phone exposure than adults. We investigated whether mobile phone use is associated with brain tumor risk among children and adolescents.
Methods
CEFALO is a multicenter case-control study conducted in Denmark, Sweden, Norway, and Switzerland that includes all children and adolescents aged 7-19 years who were diagnosed with a brain tumor between 2004 and 2008. We conducted interviews, in person, with 352 case patients (participation rate: 83%) and 646 control subjects (participation rate: 71%) and their parents. Control subjects were randomly selected from population registries and matched by age, sex, and geographical region. We asked about mobile phone use and included mobile phone operator records when available. Odds ratios (ORs) for brain tumor risk and 95% confidence intervals (CIs) were calculated using conditional logistic regression models.
Results
Regular users of mobile phones were not statistically significantly more likely to have been diagnosed with brain tumors compared with nonusers (OR = 1.36; 95% CI = 0.92 to 2.02). Children who started to use mobile phones at least 5 years ago were not at increased risk compared with those who had never regularly used mobile phones (OR = 1.26, 95% CI = 0.70 to 2.28). In a subset of study participants for whom operator recorded data were available, brain tumor risk was related to the time elapsed since the mobile phone subscription was started but not to amount of use. No increased risk of brain tumors was observed for brain areas receiving the highest amount of exposure.
Conclusion
The absence of an exposure-response relationship either in terms of the amount of mobile phone use or by localization of the brain tumor argues against a causal association. |
| doi_str_mv | 10.1093/jnci/djr244 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_542805</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jnci/djr244</oup_id><sourcerecordid>899144579</sourcerecordid><originalsourceid>FETCH-LOGICAL-c587t-c15e1a684d093cdf3741b500a9ee1352a49d7c07a7a010a031dedc4ab99e420b3</originalsourceid><addsrcrecordid>eNqF0Utv1DAQAGALgei2cOKOLCTggEJtZxzH3JaIl9QKJNqz5cSzbZZsvNixUP99HbIUiUPxxa_PY3uGkGecveVMl6fbsetP3TYIgAdkxaFiheBMPiQrxoQq6lrBETmOccty0wIekyPBlZZVJVfEnPu2H5B-u_Yj0suI1I6Ovg-2H-lF2vkQaR411_3gAo6_N9fODxg7HKf4jq7peRqmfp5hoI2NWDR-nIIf6PcpuZsn5NHGDhGfHvoTcvnxw0XzuTj7-ulLsz4rOlmrqei4RG6rGlz-Uec2pQLeSsasRuSlFBa0Ux1TVlnGmWUld-g6sK3WCIK15QkplrjxF-5Ta_ah39lwY7ztzWHpRx6hkSBqJu_1V2lv8tJVmj0HJUBk_3rx--B_JoyT2fU5B8NgR_QpmlprDiCV_r-sQVQaOM_yxT9y61MYc5oyqhhwxcuM3iyoCz7GgJu7p3Jm5vqbuf5mqX_Wzw8hU7tDd2f_FDyDlwdgY2eHTbD5dPzrAFRZVvO1rxbnczLuu_EWvpPFrw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>886041713</pqid></control><display><type>article</type><title>Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><creator>Aydin, Denis ; Feychting, Maria ; Schüz, Joachim ; Tynes, Tore ; Andersen, Tina Veje ; Schmidt, Lisbeth Samsø ; Poulsen, Aslak Harbo ; Johansen, Christoffer ; Prochazka, Michaela ; Lannering, Birgitta ; Klæboe, Lars ; Eggen, Tone ; Jenni, Daniela ; Grotzer, Michael ; Von der Weid, Nicolas ; Kuehni, Claudia E. ; Röösli, Martin</creator><creatorcontrib>Aydin, Denis ; Feychting, Maria ; Schüz, Joachim ; Tynes, Tore ; Andersen, Tina Veje ; Schmidt, Lisbeth Samsø ; Poulsen, Aslak Harbo ; Johansen, Christoffer ; Prochazka, Michaela ; Lannering, Birgitta ; Klæboe, Lars ; Eggen, Tone ; Jenni, Daniela ; Grotzer, Michael ; Von der Weid, Nicolas ; Kuehni, Claudia E. ; Röösli, Martin</creatorcontrib><description>Background
It has been hypothesized that children and adolescents might be more vulnerable to possible health effects from mobile phone exposure than adults. We investigated whether mobile phone use is associated with brain tumor risk among children and adolescents.
Methods
CEFALO is a multicenter case-control study conducted in Denmark, Sweden, Norway, and Switzerland that includes all children and adolescents aged 7-19 years who were diagnosed with a brain tumor between 2004 and 2008. We conducted interviews, in person, with 352 case patients (participation rate: 83%) and 646 control subjects (participation rate: 71%) and their parents. Control subjects were randomly selected from population registries and matched by age, sex, and geographical region. We asked about mobile phone use and included mobile phone operator records when available. Odds ratios (ORs) for brain tumor risk and 95% confidence intervals (CIs) were calculated using conditional logistic regression models.
Results
Regular users of mobile phones were not statistically significantly more likely to have been diagnosed with brain tumors compared with nonusers (OR = 1.36; 95% CI = 0.92 to 2.02). Children who started to use mobile phones at least 5 years ago were not at increased risk compared with those who had never regularly used mobile phones (OR = 1.26, 95% CI = 0.70 to 2.28). In a subset of study participants for whom operator recorded data were available, brain tumor risk was related to the time elapsed since the mobile phone subscription was started but not to amount of use. No increased risk of brain tumors was observed for brain areas receiving the highest amount of exposure.
Conclusion
The absence of an exposure-response relationship either in terms of the amount of mobile phone use or by localization of the brain tumor argues against a causal association.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/djr244</identifier><identifier>PMID: 21795665</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adolescent ; adverse effects ; Biological and medical sciences ; Brain cancer ; Brain Neoplasms ; Brain Neoplasms - epidemiology ; Brain Neoplasms - etiology ; Cancer and Oncology ; Cancer och onkologi ; Case-Control Studies ; Cell Phone - statistics & numerical data ; Cellular Phone ; Cellular telephones ; Child ; Childrens health ; Confounding Factors (Epidemiology) ; Denmark ; Denmark - epidemiology ; Electromagnetic Fields ; Electromagnetic Fields - adverse effects ; epidemiology ; etiology ; Female ; Glioma ; Glioma - epidemiology ; Glioma - etiology ; Health risk assessment ; Humans ; Incidence ; Male ; Medical diagnosis ; Medical sciences ; Neurology ; Norway ; Norway - epidemiology ; Odds Ratio ; Questionnaires ; Registries ; Research Design ; Risk Assessment ; Risk Factors ; statistics & numerical data ; Surveys and Questionnaires ; Sweden ; Sweden - epidemiology ; Switzerland ; Switzerland - epidemiology ; Tumors ; Tumors of the nervous system. Phacomatoses ; Young Adult</subject><ispartof>JNCI : Journal of the National Cancer Institute, 2011-08, Vol.103 (16), p.1264-1276</ispartof><rights>The Author 2011. Published by Oxford University Press. 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Aug 17, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-c15e1a684d093cdf3741b500a9ee1352a49d7c07a7a010a031dedc4ab99e420b3</citedby><cites>FETCH-LOGICAL-c587t-c15e1a684d093cdf3741b500a9ee1352a49d7c07a7a010a031dedc4ab99e420b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24473363$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21795665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/147242$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:123087303$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Aydin, Denis</creatorcontrib><creatorcontrib>Feychting, Maria</creatorcontrib><creatorcontrib>Schüz, Joachim</creatorcontrib><creatorcontrib>Tynes, Tore</creatorcontrib><creatorcontrib>Andersen, Tina Veje</creatorcontrib><creatorcontrib>Schmidt, Lisbeth Samsø</creatorcontrib><creatorcontrib>Poulsen, Aslak Harbo</creatorcontrib><creatorcontrib>Johansen, Christoffer</creatorcontrib><creatorcontrib>Prochazka, Michaela</creatorcontrib><creatorcontrib>Lannering, Birgitta</creatorcontrib><creatorcontrib>Klæboe, Lars</creatorcontrib><creatorcontrib>Eggen, Tone</creatorcontrib><creatorcontrib>Jenni, Daniela</creatorcontrib><creatorcontrib>Grotzer, Michael</creatorcontrib><creatorcontrib>Von der Weid, Nicolas</creatorcontrib><creatorcontrib>Kuehni, Claudia E.</creatorcontrib><creatorcontrib>Röösli, Martin</creatorcontrib><title>Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>Background
It has been hypothesized that children and adolescents might be more vulnerable to possible health effects from mobile phone exposure than adults. We investigated whether mobile phone use is associated with brain tumor risk among children and adolescents.
Methods
CEFALO is a multicenter case-control study conducted in Denmark, Sweden, Norway, and Switzerland that includes all children and adolescents aged 7-19 years who were diagnosed with a brain tumor between 2004 and 2008. We conducted interviews, in person, with 352 case patients (participation rate: 83%) and 646 control subjects (participation rate: 71%) and their parents. Control subjects were randomly selected from population registries and matched by age, sex, and geographical region. We asked about mobile phone use and included mobile phone operator records when available. Odds ratios (ORs) for brain tumor risk and 95% confidence intervals (CIs) were calculated using conditional logistic regression models.
Results
Regular users of mobile phones were not statistically significantly more likely to have been diagnosed with brain tumors compared with nonusers (OR = 1.36; 95% CI = 0.92 to 2.02). Children who started to use mobile phones at least 5 years ago were not at increased risk compared with those who had never regularly used mobile phones (OR = 1.26, 95% CI = 0.70 to 2.28). In a subset of study participants for whom operator recorded data were available, brain tumor risk was related to the time elapsed since the mobile phone subscription was started but not to amount of use. No increased risk of brain tumors was observed for brain areas receiving the highest amount of exposure.
Conclusion
The absence of an exposure-response relationship either in terms of the amount of mobile phone use or by localization of the brain tumor argues against a causal association.</description><subject>Adolescent</subject><subject>adverse effects</subject><subject>Biological and medical sciences</subject><subject>Brain cancer</subject><subject>Brain Neoplasms</subject><subject>Brain Neoplasms - epidemiology</subject><subject>Brain Neoplasms - etiology</subject><subject>Cancer and Oncology</subject><subject>Cancer och onkologi</subject><subject>Case-Control Studies</subject><subject>Cell Phone - statistics & numerical data</subject><subject>Cellular Phone</subject><subject>Cellular telephones</subject><subject>Child</subject><subject>Childrens health</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Denmark</subject><subject>Denmark - epidemiology</subject><subject>Electromagnetic Fields</subject><subject>Electromagnetic Fields - adverse effects</subject><subject>epidemiology</subject><subject>etiology</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - epidemiology</subject><subject>Glioma - etiology</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Norway</subject><subject>Norway - epidemiology</subject><subject>Odds Ratio</subject><subject>Questionnaires</subject><subject>Registries</subject><subject>Research Design</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>statistics & numerical data</subject><subject>Surveys and Questionnaires</subject><subject>Sweden</subject><subject>Sweden - epidemiology</subject><subject>Switzerland</subject><subject>Switzerland - epidemiology</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Young Adult</subject><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqF0Utv1DAQAGALgei2cOKOLCTggEJtZxzH3JaIl9QKJNqz5cSzbZZsvNixUP99HbIUiUPxxa_PY3uGkGecveVMl6fbsetP3TYIgAdkxaFiheBMPiQrxoQq6lrBETmOccty0wIekyPBlZZVJVfEnPu2H5B-u_Yj0suI1I6Ovg-2H-lF2vkQaR411_3gAo6_N9fODxg7HKf4jq7peRqmfp5hoI2NWDR-nIIf6PcpuZsn5NHGDhGfHvoTcvnxw0XzuTj7-ulLsz4rOlmrqei4RG6rGlz-Uec2pQLeSsasRuSlFBa0Ux1TVlnGmWUld-g6sK3WCIK15QkplrjxF-5Ta_ah39lwY7ztzWHpRx6hkSBqJu_1V2lv8tJVmj0HJUBk_3rx--B_JoyT2fU5B8NgR_QpmlprDiCV_r-sQVQaOM_yxT9y61MYc5oyqhhwxcuM3iyoCz7GgJu7p3Jm5vqbuf5mqX_Wzw8hU7tDd2f_FDyDlwdgY2eHTbD5dPzrAFRZVvO1rxbnczLuu_EWvpPFrw</recordid><startdate>20110817</startdate><enddate>20110817</enddate><creator>Aydin, Denis</creator><creator>Feychting, Maria</creator><creator>Schüz, Joachim</creator><creator>Tynes, Tore</creator><creator>Andersen, Tina Veje</creator><creator>Schmidt, Lisbeth Samsø</creator><creator>Poulsen, Aslak Harbo</creator><creator>Johansen, Christoffer</creator><creator>Prochazka, Michaela</creator><creator>Lannering, Birgitta</creator><creator>Klæboe, Lars</creator><creator>Eggen, Tone</creator><creator>Jenni, Daniela</creator><creator>Grotzer, Michael</creator><creator>Von der Weid, Nicolas</creator><creator>Kuehni, Claudia E.</creator><creator>Röösli, Martin</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20110817</creationdate><title>Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study</title><author>Aydin, Denis ; Feychting, Maria ; Schüz, Joachim ; Tynes, Tore ; Andersen, Tina Veje ; Schmidt, Lisbeth Samsø ; Poulsen, Aslak Harbo ; Johansen, Christoffer ; Prochazka, Michaela ; Lannering, Birgitta ; Klæboe, Lars ; Eggen, Tone ; Jenni, Daniela ; Grotzer, Michael ; Von der Weid, Nicolas ; Kuehni, Claudia E. ; Röösli, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-c15e1a684d093cdf3741b500a9ee1352a49d7c07a7a010a031dedc4ab99e420b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>adverse effects</topic><topic>Biological and medical sciences</topic><topic>Brain cancer</topic><topic>Brain Neoplasms</topic><topic>Brain Neoplasms - epidemiology</topic><topic>Brain Neoplasms - etiology</topic><topic>Cancer and Oncology</topic><topic>Cancer och onkologi</topic><topic>Case-Control Studies</topic><topic>Cell Phone - statistics & numerical data</topic><topic>Cellular Phone</topic><topic>Cellular telephones</topic><topic>Child</topic><topic>Childrens health</topic><topic>Confounding Factors (Epidemiology)</topic><topic>Denmark</topic><topic>Denmark - epidemiology</topic><topic>Electromagnetic Fields</topic><topic>Electromagnetic Fields - adverse effects</topic><topic>epidemiology</topic><topic>etiology</topic><topic>Female</topic><topic>Glioma</topic><topic>Glioma - epidemiology</topic><topic>Glioma - etiology</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Norway</topic><topic>Norway - epidemiology</topic><topic>Odds Ratio</topic><topic>Questionnaires</topic><topic>Registries</topic><topic>Research Design</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>statistics & numerical data</topic><topic>Surveys and Questionnaires</topic><topic>Sweden</topic><topic>Sweden - epidemiology</topic><topic>Switzerland</topic><topic>Switzerland - epidemiology</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aydin, Denis</creatorcontrib><creatorcontrib>Feychting, Maria</creatorcontrib><creatorcontrib>Schüz, Joachim</creatorcontrib><creatorcontrib>Tynes, Tore</creatorcontrib><creatorcontrib>Andersen, Tina Veje</creatorcontrib><creatorcontrib>Schmidt, Lisbeth Samsø</creatorcontrib><creatorcontrib>Poulsen, Aslak Harbo</creatorcontrib><creatorcontrib>Johansen, Christoffer</creatorcontrib><creatorcontrib>Prochazka, Michaela</creatorcontrib><creatorcontrib>Lannering, Birgitta</creatorcontrib><creatorcontrib>Klæboe, Lars</creatorcontrib><creatorcontrib>Eggen, Tone</creatorcontrib><creatorcontrib>Jenni, Daniela</creatorcontrib><creatorcontrib>Grotzer, Michael</creatorcontrib><creatorcontrib>Von der Weid, Nicolas</creatorcontrib><creatorcontrib>Kuehni, Claudia E.</creatorcontrib><creatorcontrib>Röösli, Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aydin, Denis</au><au>Feychting, Maria</au><au>Schüz, Joachim</au><au>Tynes, Tore</au><au>Andersen, Tina Veje</au><au>Schmidt, Lisbeth Samsø</au><au>Poulsen, Aslak Harbo</au><au>Johansen, Christoffer</au><au>Prochazka, Michaela</au><au>Lannering, Birgitta</au><au>Klæboe, Lars</au><au>Eggen, Tone</au><au>Jenni, Daniela</au><au>Grotzer, Michael</au><au>Von der Weid, Nicolas</au><au>Kuehni, Claudia E.</au><au>Röösli, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>2011-08-17</date><risdate>2011</risdate><volume>103</volume><issue>16</issue><spage>1264</spage><epage>1276</epage><pages>1264-1276</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>Background
It has been hypothesized that children and adolescents might be more vulnerable to possible health effects from mobile phone exposure than adults. We investigated whether mobile phone use is associated with brain tumor risk among children and adolescents.
Methods
CEFALO is a multicenter case-control study conducted in Denmark, Sweden, Norway, and Switzerland that includes all children and adolescents aged 7-19 years who were diagnosed with a brain tumor between 2004 and 2008. We conducted interviews, in person, with 352 case patients (participation rate: 83%) and 646 control subjects (participation rate: 71%) and their parents. Control subjects were randomly selected from population registries and matched by age, sex, and geographical region. We asked about mobile phone use and included mobile phone operator records when available. Odds ratios (ORs) for brain tumor risk and 95% confidence intervals (CIs) were calculated using conditional logistic regression models.
Results
Regular users of mobile phones were not statistically significantly more likely to have been diagnosed with brain tumors compared with nonusers (OR = 1.36; 95% CI = 0.92 to 2.02). Children who started to use mobile phones at least 5 years ago were not at increased risk compared with those who had never regularly used mobile phones (OR = 1.26, 95% CI = 0.70 to 2.28). In a subset of study participants for whom operator recorded data were available, brain tumor risk was related to the time elapsed since the mobile phone subscription was started but not to amount of use. No increased risk of brain tumors was observed for brain areas receiving the highest amount of exposure.
Conclusion
The absence of an exposure-response relationship either in terms of the amount of mobile phone use or by localization of the brain tumor argues against a causal association.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>21795665</pmid><doi>10.1093/jnci/djr244</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | JNCI : Journal of the National Cancer Institute, 2011-08, Vol.103 (16), p.1264-1276 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adolescent adverse effects Biological and medical sciences Brain cancer Brain Neoplasms Brain Neoplasms - epidemiology Brain Neoplasms - etiology Cancer and Oncology Cancer och onkologi Case-Control Studies Cell Phone - statistics & numerical data Cellular Phone Cellular telephones Child Childrens health Confounding Factors (Epidemiology) Denmark Denmark - epidemiology Electromagnetic Fields Electromagnetic Fields - adverse effects epidemiology etiology Female Glioma Glioma - epidemiology Glioma - etiology Health risk assessment Humans Incidence Male Medical diagnosis Medical sciences Neurology Norway Norway - epidemiology Odds Ratio Questionnaires Registries Research Design Risk Assessment Risk Factors statistics & numerical data Surveys and Questionnaires Sweden Sweden - epidemiology Switzerland Switzerland - epidemiology Tumors Tumors of the nervous system. Phacomatoses Young Adult |
| title | Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study |
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